Table_1_MicroRNAs (miRNAs): Novel potential therapeutic targets in colorectal cancer.docx

Colorectal cancer (CRC) is the most common malignant tumor and one of the most lethal malignant tumors in the world. Despite treatment with a combination of surgery, radiotherapy, and/or systemic treatment, including chemotherapy and targeted therapy, the prognosis of patients with advanced CRC remains poor. Therefore, there is an urgent need to explore novel therapeutic strategies and targets for the treatment of CRC. MicroRNAs (miRNAs/miRs) are a class of short noncoding RNAs (approximately 22 nucleotides) involved in posttranscriptional gene expression regulation. The dysregulation of its expression is recognized as a key regulator related to the development, progression and metastasis of CRC. In recent years, a number of miRNAs have been identified as regulators of drug resistance in CRC, and some have gained attention as potential targets to overcome the drug resistance of CRC. In this review, we introduce the miRNAs and the diverse mechanisms of miRNAs in CRC and summarize the potential targeted therapies of CRC based on the miRNAs.</p

Visualization 1: Aberration compensation for optical trapping of cells within living mice

Optical trapping and separation of a RBC apart from the RBC clumps within a living mouse. (Bar = 10 µm. “+” indicates the trap center.) Originally published in Applied Optics on 01 March 2017 (ao-56-7-1972

Visualization 2: Oscillations of absorbing particles at the water-air interface induced by laser tweezers

Oscillations of absorbing particles at the water-air interface. (Bar=5 µm. “+” indicates the trap center.) Originally published in Optics Express on 06 February 2017 (oe-25-3-2481

Visualization 1: Oscillations of absorbing particles at the water-air interface induced by laser tweezers

Bubble volume increasing. (Bar=5 µm. “+” indicates the trap center.) Originally published in Optics Express on 06 February 2017 (oe-25-3-2481

Data_Sheet_1_Fluorescent Detection of the Ubiquitous Bacterial Messenger 3′,5′ Cyclic Diguanylic Acid by Using a Small Aromatic Molecule.PDF

3′,5′ Cyclic diguanylic acid (c-di-GMP) has been shown to play a central role in the regulation of bacterial physiological processes such as biofilm formation and virulence production, and is regarded as a potential target for the development of anti-infective drugs. A method for the facile detection of the bacterial level of cellular c-di-GMP is required to explore the details of c-di-GMP signaling and design drugs on the basis of this pathway. Current methods of c-di-GMP detection have limited sensitivity or difficultly in probe preparation. Herein a new fluorescent probe is reported for the detection of c-di-GMP at concentrations as low as 500 nM. The probe was developed on the basis of the G-quadruplex formation of c-di-GMP induced by aromatic molecules. When used on crude bacterial cell lysates, it can effectively distinguish between the low c-di-GMP levels of bacteria in plankton and the high c-di-GMP levels in biofilm. The method described here is simple, inexpensive, sensitive, and suitable for practical applications involving the rapid detection of cellular c-di-GMP levels in vitro after simple bacterial lysis and filtration.</p

Media 1: Optical trapping of red blood cells in living animals with a water immersion objective

Originally published in Optics Letters on 01 December 2013 (ol-38-23-5134

Greenly and Efficiently Dyeing Cotton Fabric with Custom-Tailored Reactive Dyes via Electron Beam Irradiation

Traditional dyeing processes of the textile industry have to use a lot of dyeing assistants and water, resulting in massive lower-biodegradable wastewater and causing great environmental pressure. In this study, we developed a green textile dyeing route featuring high dyeing efficiency and low effluent by using electron beam (E-Beam) irradiation to trigger cotton fabric dyeing with custom-tailored reactive dyes. In which, three vinyl-containing reactive dyes with primary colors were first synthesized and then covalently bonded to cotton fibers via graft copolymerization. The color of the fabric can be facilely tuned by adjusting the ratios of the custom-tailored dyes, which achieved high brilliancy, rich hues, and excellent wash-fastness. Different from the traditional dyeing process, the E-Beam irradiation-induced dyeing process was performed successfully with no requirement to salt, alkali, or heat conditions. Moreover, the utilization of all three dyes was nearly 100% in the E-Beam irradiation-induced dyeing process. Also, almost no residual dyes were washed off from the dyed cotton fabric during the washing process; thus, the spent washing stream exhibited so clean that it completely met the requirements of the zero discharge of hazardous chemical program. This study demonstrated that here E-Beam irradiation-induced dyeing on cotton fabric is a novel green textile dyeing route with energy-saving and pollution-free features, which is beneficial to the transformation to green and sustainable development of the traditional textile industry