Data_Sheet_1_Variable-Density Flow and Solute Transport in Stratified Salt Marshes.pdf

Subsurface hydrodynamics underpin the eco-functions of salt marshes. Many studies have investigated these processes under various conditions. However, the impact of soil stratification (a low-permeability mud layer overlying a high-permeability sand layer) on the variable-density groundwater flow (particularly unstable flow) and solute transport in regularly tide-flooded marshes remains poorly understood. The present study numerically explored this question based on a 2D cross-creek section of salt marshes, by comparing cases with and without stratification. Results show that, the low-permeability mud layer delays the initiation of unstable flow and leads to smaller and denser salt fingers. Consequently, solute plume stays in the marsh soil for a longer time and spreads more widely than that in the homogeneous case. Also, soil stratigraphy extends the duration and shrinks the zone of solute discharge across the tidal creek. Sensitivity analysis was conducted based on three key controlling variables: hydraulic conductivity contrast between mud layer and sand layer (Kmud/Ksand), salinity contrast between surface water and groundwater (Csea/Cpore), and mud layer thickness (Dmud). The results demonstrate that the residence time of solute plume in a two-layered salt marsh is less sensitive to Csea/Cpore than to Kmud/Ksand and Dmud. Moreover, the commencement and duration of solute discharge are more sensitive to Kmud/Ksand and Dmud than to Csea/Cpore. While the location of solute discharge zone is highly sensitive to Dmud and slightly influenced by Kmud/Ksand and Csea/Cpore. Findings from this study would facilitate a deeper understanding of the eco-functions of salt marshes.</p

DataSheet_1_A nomogram based on the preoperative neutrophil-to-lymphocyte ratio to distinguish sarcomatoid renal cell carcinoma from clear cell renal cell carcinoma.docx

ObjectiveOur study aimed to assess the predictive value of the preoperative neutrophil-to-lymphocyte ratio(NLR) in distinguishing sarcomatoid renal cell carcinoma (SRCC) from clear cell renal cell carcinoma(CCRCC) and to developing a nomogram based on the preoperative NLR and other factors to distinguish SRCC from CCRCC.Materials and methodsThe database involved 280 patients, including 46 SRCC and 234 CCRCC. logistic analysis was conducted to select the variables associated with identifying SRCC preoperatively, and subgroup analysis was used to further validate the ability of NLR with preoperative identification of SRCC.In addition, The data were randomly separated into a training cohort(n=195) and a validation cohort(n=85). And an NLR-based nomogram was plotted based on the logistic analysis results. The nomogram was evaluated according to its discrimination, consistency, and clinical benefits.ResultsMultivariate analysis indicated that NLR, flank pain, tumor size, and total cholesterol(TC) were independent risk factors for identifying SRCC. The results of subgroup analysis showed that higher NLR was associated with a higher probability of SRCC in most subgroups. The area under the curve(AUC) of the training and validation cohorts were 0.801 and 0.738, respectively. The results of the calibration curve show high consistency between predicted and actual results. Decision Curve Analysis(DCA) showed clinical intervention based on the model was beneficial over most of the threshold risk range.ConclusionNLR is a potential indicator for preoperative differentiation of SRCC and CCRCC, and the predictive model constructed based on NLR has a good predictive ability. The new model could provide suggestions for the early identification of SRCC.</p

Spectroscopic Study of the Behavior of Mo(VI) and W(VI) Polyanions in Sulfuric–Phosphoric Acid Mixtures

The solution chemistry of Mo­(VI) and W­(VI) in mixtures of sulfuric and phosphoric acids is relevant to the development of practicable hydrometallurgical processes for the recovery and separation of these two elements from low-grade scheelite ores. The behavior of Mo­(VI) and W­(VI) in such mixtures has been studied using X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS), nuclear magnetic resonance (NMR), and small-angle X-ray scattering (SAXS) spectroscopies, along with electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). Where applicable, these techniques have produced a self-consistent picture of the similarities and differences between the chemical speciation of Mo­(VI) and W­(VI) as functions of solution composition, mostly at a constant phosphorous/metal (P/M; M = Mo­(VI) or W­(VI)) ratio of ∼1. In dilute acidic media (0.02 mol·kg–1 H+, without H2SO4), Mo­(VI) exists mostly (∼60%) as P2Mo5O236– with the remaining ∼40% as β-Mo8O264–. Under the same conditions, W­(VI) is largely present as NaPW11O396– (∼80%) and P2W5O236– (∼10%), with the remainder probably occurring as isopolytungstates such as W12O4212– and some tungstophosphate dimers such as P2W18O626–. At higher acid concentrations (≲5 mol·kg–1 H2SO4), polymeric Mo­(VI) anions are broken down to form the oxocations MoO22+ and Mo2O52+ and their protonated forms, with the dimers becoming increasingly dominant at higher acidities (∼80% in 5 mol·kg–1 H2SO4). In stark contrast, W­(VI) polyanions do not decompose at higher acidities but instead form (∼70% in 0.6 mol·kg–1 H2SO4) a Keggin ion, PW12O403–. Further acidification with H2SO4 results in the agglomeration of this Keggin ion, forming clusters of about 50 and 100 Å in diameter that ultimately produce crystalline precipitates, which could be identified in part by their X-ray diffraction patterns. Possible application of these findings to the hydrometallurgical separation of Mo and W using acidic solutions is briefly discussed, based on a limited number of batch solvent extractions

DataSheet1_Sarcomatoid-associated gene risk index for clear cell renal cell carcinoma.xlsx

Sarcomatoid renal cell carcinoma is a de-differentiated form of kidney cancer with an extremely poor prognosis. Genes associated with sarcomatoid differentiation may be closely related to the prognosis of renal cell carcinoma. The prognosis of renal cell carcinoma itself is extremely variable, and a new prognostic model is needed to stratify patients and guide treatment. Data on clear cell renal cell carcinoma with or without sarcomatoid differentiation were obtained from TCGA database, and a sarcomatoid-associated gene risk index (SAGRI) and column line graphs were constructed using sarcomatoid-associated genes. The predictive power of the SAGRI and column line graphs was validated using an internal validation set and an independent validation set (E-MTAB-1980). The SAGRI was constructed using four sarcoma-like differentiation-related genes, COL7A1, LCTL, NPR3, ZFHX4, and had a 1-year AUC value of 0.725 in the training set, 0.712 in the internal validation set, and 0.770 in the independent validation set for TCGA training cohort, with high model reliability. The molecular characteristics among the SAGRI subgroups were analyzed by multiple methods, and results suggested that the SAGRI-HIGH subgroup may benefit more from immunotherapy to improve prognosis. SAGRI satisfactorily predicted the prognosis of patients with clear cell renal cell carcinoma with or without sarcomatoid differentiation.</p

Additional file 3 of SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

Additional file 3. Mass spectrometry identification data for the interactomics of SMYD3 (the protein score equal to or higher than two)

sj-docx-1-tct-10.1177_15330338231195494 - Supplemental material for Predictive Models for Colon Adenocarcinoma Diagnosis, Prognosis, and Immune Microenvironment Based on 2 Hypoxia-Related Genes: KDM3A and ENO3

Supplemental material, sj-docx-1-tct-10.1177_15330338231195494 for Predictive Models for Colon Adenocarcinoma Diagnosis, Prognosis, and Immune Microenvironment Based on 2 Hypoxia-Related Genes: KDM3A and ENO3 by Chunli Kong, Liyun Zheng, Shiji Fang, Minjiang Chen, Guihan Lin, Rongfang Qiu, Zhongwei Zhao, Weiqian Chen, Jingjing Song, Yang Yang and Jiansong Ji in Technology in Cancer Research & Treatment</p

Additional file 4 of SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

Additional file 4: Fig. S1. PPI analysis of SMYD3-associated proteins

Additional file 2 of SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

Additional file 2. Raw date of gene expression and log2fc of differentially expressed genes (DEGs) between 5 pairs of HCC and adjacent normal tissues in RNA seq results

Additional file 1 of Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization

Additional file 1: Figure S1. The particle size of MS, ADM-MS and ADM/Fe3O4-MS. The results showed that the prepared MS, ADM-MS and ADM/Fe3O4-MS in this study had relatively uniform particle sizes, and the particle sizes of most microspheres were between 200 to 300 μm, which were 223.3 ± 91.1 μm, 210.8 ± 71.8 μm and 217.7 ± 57.4 μm, respectively. Figure S2. T2-weighted relaxation value of MS, ADM-MS and ADM/Fe3O4-MS with different contents

Additional file 8 of SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

Additional file 8. Images of the full immunoblots