27 research outputs found

    808 nm Light-Triggered ThermometerÔÇôHeater Upconverting Platform Based on Nd<sup>3+</sup>-Sensitized YolkÔÇôShell GdOF@SiO<sub>2</sub>

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    The realization of real-time and accurate temperature reading at subcutaneous level during the photothermal therapy (PTT) could maximally avoid the collateral damages induced by overheating effects, which remains a formidable challenge for biomedical applications. Herein, 808 nm light-driven yolkÔÇôshell GdOF:Nd<sup>3+</sup>/Yb<sup>3+</sup>/Er<sup>3+</sup>@SiO<sub>2</sub> microcapsules were developed with thermal-sensing and heating bifunctions. Under 808 nm excitation, sensitive thermometry was implemented by monitoring thermoresponsive emission from <sup>2</sup>H<sub>11/2</sub>/<sup>4</sup>S<sub>3/2</sub> levels of Er<sup>3+</sup>; meanwhile, the addition of Nd<sup>3+</sup> with rich metastable intermediate levels and the yolkÔÇôshell configuration with large specific surface area triggered efficient light-to-heat conversion via enhanced nonradiative channels. The potentiality of dual-functional samples for controlled subcutaneous photothermal treatment was validated through ex vivo experiments, and the antibacterial activity against Escherichia coli was also elaborately evaluated. Results open a general avenue for designing and developing upconverting platforms with sensitive thermal-sensing and efficient heating bifunctions, which makes a significant step toward the achievement of real-time controlled PTT

    Toughening Elastomers Using a Mussel-Inspired Multiphase Design

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    It is a challenge to simultaneously achieve high stretchability, high modulus, and recoverability of polymers. Inspired by the multiphase structure of mussel byssus cuticles, we circumvent this dilemma by introducing a deformable microphase-separated granule with rich coordination into a ductile rubber network. The granule can serve as an additional cross-link to improve the modulus, while the sacrificial, reversible coordination can dissociate and reconstruct continuously during stretching to dissipate energy. The elastomer with such a bioinspired multiphase structure exhibits over a 10-fold increase in toughness compared to the original sample. We envision that this work offers a novel yet facile biomimetic route toward high-performance elastomers

    Eosinophil inflammation assessed with hematoxylin and eosin (HE)-stained tissue sections of the nasal mucosa and lung.

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    <p>Original magnification was ├Ś 400 for nose and ├Ś 200 for lung (A). Numbers of eosinophils in the nasal mucosa (B) and inflammation scores of the lung (C) were counted to verify the altered inflammation among groups. Eosinophil infiltration was significantly higher in low-fiber group than in the AAD model group. Interestingly, dietary fiber intervention drastically suppressed eosinophil inflammation. In addition, numbers of eosinophils in pectin group were lower than in the cellulose group. Scale bars, 200 ╬╝m for Nose; scale bars, 500 ╬╝m for Lung. Data expressed as mean ┬▒ SEM, n = 10; *<i>p</i><0.05, **<i>p</i><0.01 as conducted.</p

    Altered levels of cytokines IL-4, IL-10 and IFN-╬│ in NALF (A) and BALF (B).

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    <p>Dietary fiber significantly inhibited IL-4 levels accompanied by increased IFN-╬│ levels, as well as increased IL-10 secretion. Data are represented as the mean secretion pg/ml ┬▒ SEM, n = 8~10; *<i>p</i><0.05, **<i>p</i><0.01 as conducted.</p