Supplemental Material - Social media use, perceived social support, and well-being: Evidence from two waves of surveys peri- and post-COVID-19 lockdown

Supplemental Material for Social media use, perceived social support, and well-being: Evidence from two waves of surveys peri- and post-COVID-19 lockdown by Zhiying Yue, Renwen Zhang, and Jun Xiao in Journal of Social and Personal Relationships</p

Table_1_Challenges with using popular entertainment to address mental health: a content analysis of Netflix series 13 Reasons Why controversy in mainstream news coverage.xlsx

BackgroundMental health conditions and psychiatric disorders are among the leading causes of illness, disability, and death among young people around the globe. In the United States, teen suicide has increased by about 30% in the last decade. Raising awareness of warning signs and promoting access to mental health resources can help reduce suicide rates for at-risk youth. However, death by suicide remains a taboo topic for public discourse and societal intervention. An unconventional approach to address taboo topics in society is the use of popular media.MethodWe conducted a quantitative content analysis of mainstream news reporting on the controversial Netflix series 13 Reasons Why Season 1. Using a combination of top-down and bottom-up search strategies, our final sample consisted of 97 articles published between March 31 and May 31, 2017, from 16 media outlets in 3,150 sentences. We systematically examined the news framing in these articles in terms of content and valence, the salience of health/social issue related frames, and their compliance with the WHO guidelines.ResultsNearly a third of the content directly addressed issues of our interest: 61.6% was about suicide and 38.4% was about depression, bullying, sexual assault, and other related health/social issues; it was more negative (42.8%) than positive (17.4%). The criticism focused on the risk of suicide contagion, glamorizing teen suicide, and the portrayal of parents and educators as indifferent and incompetent. The praise was about the show raising awareness of real and difficult issues young people struggle with in their everyday life and serving as a conversation starter to spur meaningful discussions. Our evaluation of WHO guideline compliance for reporting on suicide yielded mixed results. Although we found recommended practices across all major categories, they were minimal and could be improved.ConclusionDespite their well intentions and best efforts, the 13 Reasons Why production team missed several critical opportunities to be better prepared and more effective in creating social impact entertainment and fostering difficult dialogs. There is an urgent need to train news reporters about established health communication guidelines and promote best practices in media reporting on sensitive topics such as suicide.</p

Social media use, psychological well-being and physical health during lockdown

In efforts to curb the spread of COVID-19, many countries have implemented a variety of lockdown and quarantine measures. With substantially reduced face-to-face interactions, many people may have relied heavily on social media for connection, information, and entertainment. However, little is known about the psychological and physical health implications of social media use during strict lockdown. The current study investigates the associations of social media use with psychological well-being and physical health among Wuhan residents (N = 1214). Our findings showed that non-COVID related self-disclosure was positively associated with psychological well-being, while COVID related information consumption and sharing were negatively associated with psychological well-being. Further, more generic use of social media was associated with lower psychological well-being, which in turn related to more somatic symptoms. Quarantined people used social media more frequently than non-quarantined people. Importantly, the negative association between social media use and psychological well-being was significantly stronger for quarantined people than unquarantined people.</p

sj-docx-1-crx-10.1177_00936502231154146 – Supplemental material for When the Personal Becomes Political: Unpacking the Dynamics of Sexual Violence and Gender Justice Discourses Across Four Social Media Platforms

Supplemental material, sj-docx-1-crx-10.1177_00936502231154146 for When the Personal Becomes Political: Unpacking the Dynamics of Sexual Violence and Gender Justice Discourses Across Four Social Media Platforms by Jiyoun Suk, Yini Zhang, Zhiying Yue, Rui Wang, Xinxia Dong, Dongdong Yang and Ruixue Lian in Communication Research</p

Supplemental Table 2 from Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption

The sequences of primers used in this study</p

Supplemental Figure legend from Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption

Supplemental Figure legend</p

Supplemental Table 1 from Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption

Epidemiological, clinical, and pathological characteristics of 52 GCTB patients</p

Supplemental Figure 1 from Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption

Western blotting analysis of phosphorylated p65 (p-p65) in normal bone tissues (n=7) and GCTB tumor tissues (n=7).</p

GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147

Abstract Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro. Mechanistically, GnIH/Gpr147 inhibits osteoclastogenesis by the PI3K/AKT, MAPK, NF-κB and Nfatc1 signaling pathways. Furthermore, GnIH treatment was able to alleviate bone loss in aging, ovariectomy (OVX) or LPS-induced mice. Moreover, the therapy using green light promotes the release of GnIH and rescues OVX-induced bone loss. In humans, serum GnIH increases and bone resorption markers decrease after green light exposure. Therefore, our study elucidates that GnIH plays an important role in maintaining bone homeostasis via modulating osteoclast differentiation and demonstrates the potential of GnIH therapy or green light therapy in preventing osteoporosis.</p