Improvement of Green Upconversion Monochromaticity by Doping Eu³⁺ in Lu₂O₃:Yb³⁺/Ho³⁺ Powders with Detailed Investigation of the Energy Transfer Mechanism

The monochromaticity improvement of green upconversion (UC) in Lu₂O₃:Yb³⁺/Ho³⁺ powders has been successfully realized by tridoping Eu³⁺. The integral area ratio of green emission to red emission of Ho³⁺ increases 4.3 times with increasing Eu³⁺ doping concentration from 0 to 20 mol %. The energy transfer (ET) mechanism in the Yb³⁺/Ho³⁺/Eu³⁺ tridoping system has been investigated carefully by visible and near-infrared (NIR) emission spectra along with the decay curves, revealing the existence of ET from the Ho³⁺ ⁵F₄/⁵S₂ level tothe Eu³⁺ ⁵D₀ level and ET from the Ho³⁺ ⁵I₆ level to the Eu³⁺ ⁷F₆ level. In addition, the population routes of the red-emitting Ho³⁺ ⁵F₅ level in the Yb³⁺/Ho³⁺ codoped system under 980 nm wavelength excitation have also been explored. The ET process from the Yb³⁺ ²F_5/2 level to the Ho³⁺ ⁵I₇ level and the cross-relaxation process between two nearby Ho³⁺ ions in the ⁵F₄/⁵S₂ level and ⁵I₇ level, respectively, have been demonstrated to be the dominant approaches for populating the Ho³⁺ ⁵F₅ level. The multiphonon relaxation process originating from the Ho³⁺ ⁵F₄/⁵S₂ level is useless to populate the Ho³⁺ ⁵F₅ level. As the energy level gap between the Ho³⁺ ⁵I₇ level and Ho³⁺ ⁵I₈ level matches well with that between Eu³⁺ ⁷F₆ level and Eu³⁺ ⁷F₀ level, the energy of the Ho³⁺ ⁵I₇ level can be easily transferred to the Eu³⁺ ⁷F₆ level by an approximate resonant ET process, resulting in a serious decrease in the red UC emission intensity. Since this ET process is more efficient than the ET from the Ho³⁺ ⁵F₄/⁵S₂ level to the Eu³⁺ ⁵D₀ level as well as the ET from the Ho³⁺ ⁵I₆ level to the Eu³⁺ ⁷F₆ level, the integral area ratio of green emission to red emission of Ho³⁺ has been improved significantly

Enhancement of Eu³⁺ Red Upconversion in Lu₂O₃: Yb³⁺/Eu³⁺ Powders under the Assistance of Bridging Function Originated from Ho³⁺ Tridoping

The red upconversion (UC) emission of Eu³⁺ ions in Lu₂O₃: Yb³⁺/Eu³⁺ powders was successfully enhanced by tridoping Ho³⁺ ions in the matrix, which is due to the bridging function of Ho³⁺ ions. The experiment data manifest that, in Yb³⁺/Eu³⁺/Ho³⁺ tridoped system, the Ho³⁺ ions are first populated to the green emitting level ⁵F₄/⁵S₂ through the energy transfer (ET) processes from the excited Yb³⁺ ions. Subsequently, the Ho³⁺ ions at ⁵F₄/⁵S₂ level can transfer their energy to the Eu³⁺ ions at the ground state, resulting in the population of Eu³⁺ ⁵D₀ level. With the assistance of the bridging function of Ho³⁺ ion, this ET process is more efficient than the cooperative sensitization process between Yb³⁺ ion and Eu³⁺ ion. Compared with Lu₂O₃: 5 mol % Yb³⁺/1 mol % Eu³⁺, the UC intensity of Eu³⁺ ⁵D₀→⁷F₂ transition in Lu₂O₃: 5 mol % Yb³⁺/1 mol % Eu³⁺/0.5 mol % Ho³⁺ is increased by a factor of 8

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an oncometabolite. Elevated 2-HG levels are implicated in epigenetic alterations and impaired cellular differentiation. IDH1 mutations have been described in an array of hematologic malignancies and solid tumors. Here, we report the discovery of AG-120 (ivosidenib), an inhibitor of the IDH1 mutant enzyme that exhibits profound 2-HG lowering in tumor models and the ability to effect differentiation of primary patient AML samples ex vivo. Preliminary data from phase 1 clinical trials enrolling patients with cancers harboring an IDH1 mutation indicate that AG-120 has an acceptable safety profile and clinical activity