131 research outputs found

    Synthesis, Structures, and Optoelectronic Properties of Pyrene-Fused Thioxanthenes

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    A series of pyrene-fused thioxanthenes have been synthesized via a new concise route, and their crystal structures and photophysical properties have been fully investigated. The eight-ring fused dipyrene–thioxanthene (<b>DPTA</b>) can crystallize to monoclinic and triclinic X-ray structures, and their precursor has been isolated as two stable atropisomers with different photophysical properties. The <i>E</i><sub>HOMO</sub> becomes higher and the <i>E</i><sub>g</sub> become narrower as more thioxanthene unit being fused with pyrene

    Synthesis, Structures, and Optoelectronic Properties of Pyrene-Fused Thioxanthenes

    No full text
    A series of pyrene-fused thioxanthenes have been synthesized via a new concise route, and their crystal structures and photophysical properties have been fully investigated. The eight-ring fused dipyrene–thioxanthene (<b>DPTA</b>) can crystallize to monoclinic and triclinic X-ray structures, and their precursor has been isolated as two stable atropisomers with different photophysical properties. The <i>E</i><sub>HOMO</sub> becomes higher and the <i>E</i><sub>g</sub> become narrower as more thioxanthene unit being fused with pyrene

    Synthesis, Structures, and Optoelectronic Properties of Pyrene-Fused Thioxanthenes

    No full text
    A series of pyrene-fused thioxanthenes have been synthesized via a new concise route, and their crystal structures and photophysical properties have been fully investigated. The eight-ring fused dipyrene–thioxanthene (<b>DPTA</b>) can crystallize to monoclinic and triclinic X-ray structures, and their precursor has been isolated as two stable atropisomers with different photophysical properties. The <i>E</i><sub>HOMO</sub> becomes higher and the <i>E</i><sub>g</sub> become narrower as more thioxanthene unit being fused with pyrene

    Synthesis, Structures, and Optoelectronic Properties of Pyrene-Fused Thioxanthenes

    No full text
    A series of pyrene-fused thioxanthenes have been synthesized via a new concise route, and their crystal structures and photophysical properties have been fully investigated. The eight-ring fused dipyrene–thioxanthene (<b>DPTA</b>) can crystallize to monoclinic and triclinic X-ray structures, and their precursor has been isolated as two stable atropisomers with different photophysical properties. The <i>E</i><sub>HOMO</sub> becomes higher and the <i>E</i><sub>g</sub> become narrower as more thioxanthene unit being fused with pyrene

    Synthesis, Structures, and Optoelectronic Properties of Pyrene-Fused Thioxanthenes

    No full text
    A series of pyrene-fused thioxanthenes have been synthesized via a new concise route, and their crystal structures and photophysical properties have been fully investigated. The eight-ring fused dipyrene–thioxanthene (<b>DPTA</b>) can crystallize to monoclinic and triclinic X-ray structures, and their precursor has been isolated as two stable atropisomers with different photophysical properties. The <i>E</i><sub>HOMO</sub> becomes higher and the <i>E</i><sub>g</sub> become narrower as more thioxanthene unit being fused with pyrene

    Synthesis, Structures, and Optoelectronic Properties of Pyrene-Fused Thioxanthenes

    No full text
    A series of pyrene-fused thioxanthenes have been synthesized via a new concise route, and their crystal structures and photophysical properties have been fully investigated. The eight-ring fused dipyrene–thioxanthene (<b>DPTA</b>) can crystallize to monoclinic and triclinic X-ray structures, and their precursor has been isolated as two stable atropisomers with different photophysical properties. The <i>E</i><sub>HOMO</sub> becomes higher and the <i>E</i><sub>g</sub> become narrower as more thioxanthene unit being fused with pyrene

    Energy Consumption and Exergy Analysis of MEA-Based and Hydrate-Based CO<sub>2</sub> Separation

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    Carbon capture and storage (CCS) is regarded as the most efficient approach in handling the global warming crisis. MEA-based CO<sub>2</sub> capture is a well-developed chemical absorption method with a long period of industrial application. A novel hydrate-based gas separation (HBGS) method, with a wide range of advantages, has recently received special attention from researchers. In this study, two different CO<sub>2</sub> separation processes were simulated utilizing Aspen Plus software. The feasibility of both processes was validated, and the process energy consumption and exergy loss were also compared at the same flue gas condition. Some efforts have also been made to investigate the effects of different operation parameters on the process energy efficiency. Results show that the first law efficiency of the MEA-based CO<sub>2</sub> separation system is 88.19% and the second law efficiency of the system is 38.32%, while the corresponding values of the hydrate-based separation system are 74.15% and 38.85%, respectively. Cooling of the lean amine solution and the regeneration process occupy the largest portion of exergy loss in the MEA separation system. In the hydration separation, the flue gas compression and cooling are the major causes for exergy loss

    Argon Direct Analysis in Real Time Mass Spectrometry in Conjunction with Makeup Solvents: A Method for Analysis of Labile Compounds

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    Helium direct analysis in real time (He-DART) mass spectrometry (MS) analysis of labile compounds usually tends to be challenging because of the occurrence of prominent fragmentation, which obscures the assigning of an ion to an independent species or merely a fragment in a mixture. In the present work, argon DART (Ar-DART) MS in conjunction with makeup solvents has been demonstrated to analyze a variety of labile compounds including nucleosides, alkaloids, glucose, and other small molecules. The results presented here confirm that Ar-DART can generate significantly less energetic ions than conventional He-DART and is able to produce the intact molecular ions with little or no fragmentation in both positive and negative ion modes. Adding a makeup solvent (absolute ethyl alcohol, methanol, fluorobenzene, or acetone) to the argon gas stream at the exit of the DART ion source can result in 1–2 orders of magnitude increase in detection signals. The sensitivity attainable by Ar-DART was found to be comparable to that by He-DART. The investigation of influence of solvents improves our understanding of the fundamental desorption and ionization processes in DART. The practical application of this rapid and high throughput method is demonstrated by the successful analysis of a natural product (Crude Kusnezoff Monkshood) extract, demonstrating the great potential in mixture research

    Table_1_Transcriptomic analysis reveals the potential crosstalk genes and immune relationship between IgA nephropathy and periodontitis.docx

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    BackgroundIt is well known that periodontitis has an important impact on systemic diseases. The aim of this study was to investigate potential crosstalk genes, pathways and immune cells between periodontitis and IgA nephropathy (IgAN).MethodsWe downloaded periodontitis and IgAN data from the Gene Expression Omnibus (GEO) database. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were used to identify shared genes. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on the shared genes. Hub genes were further screened using least absolute shrinkage and selection operator (LASSO) regression, and a receiver operating characteristic (ROC) curve was drawn according to the screening results. Finally, single-sample GSEA (ssGSEA) was used to analyze the infiltration level of 28 immune cells in the expression profile and its relationship with shared hub genes.ResultsBy taking the intersection of WGCNA important module genes and DEGs, we found that the SPAG4, CCDC69, KRT10, CXCL12, HPGD, CLDN20 and CCL187 genes were the most important cross-talk genes between periodontitis and IgAN. GO analysis showed that the shard genes were most significantly enriched in kinase regulator activity. The LASSO analysis results showed that two overlapping genes (CCDC69 and CXCL12) were the optimal shared diagnostic biomarkers for periodontitis and IgAN. The immune infiltration results revealed that T cells and B cells play an important role in the pathogenesis of periodontitis and IgAN.ConclusionThis study is the first to use bioinformatics tools to explore the close genetic relationship between periodontitis and IgAN. The SPAG4, CCDC69, KRT10, CXCL12, HPGD, CLDN20 and CCL187 genes were the most important cross-talk genes between periodontitis and IgAN. T-cell and B-cell-driven immune responses may play an important role in the association between periodontitis and IgAN.</p

    Identification of Unfolding and Dissociation Pathways of Superoxide Dismutase in the Gas Phase by Ion-Mobility Separation and Tandem Mass Spectrometry

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    Cu, Zn-superoxide dismutase (SOD1) is a homodimeric enzyme of approximately 32 kDa. Each monomer contains one Cu<sup>2+</sup> and one Zn<sup>2+</sup> ion, which play catalytic and structural roles in the enzyme. Dimer formation is also essential to its functionality. The spatial structure of this metalloenzyme is also closely related to its bioactivities. Here we investigate the structural and conformational changes of SOD1 in the gas phase by electrospray ionization mass spectrometry (ESI-MS) and ion-mobility (IM) separation combined with tandem mass spectrometry (MS/MS). First, the composition and forms of SOD1 were analyzed by ESI-MS. The dimer, monomer, and apomonomer were observed under different solvent conditions. The dimer was found to be stable, and could retain its native structure in neutral buffer. Ion-mobility separation combined with MS/MS was used to reveal the conformational changes and dissociation process of SOD1 when it was activated in the gas phase. Three different dimeric and two monomeric conformers were observed; three unfolding and dissociation pathways were also identified. The results from this study demonstrate that IM-MS/MS could be used to obtain spatial structural information on SOD1 and that the technique could therefore be employed to investigate the conformational changes in mutant SOD1, which is related to amyotrophic lateral sclerosis and other neurodegenerative disorders
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