Supplementary figures: Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in colorectal cancer: a meta-analysis

These are peer-reviewed supplementary materials for the article 'Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in colorectal cancer: a meta-analysis' published in the Journal of Comparative Effectiveness Research.supplementary figure 1supplementary figure 2supplementary figure 3supplementary figure 4supplementary figure 5supplementary figure 6supplementary figure 7supplementary figure 8supplementary figure 9Aims: To evaluate the efficacy and safety of PD-1/PD-L1 and/or CTLA-4 inhibitors in the treatment of colorectal cancer (CRC) by meta-analysis. Methods: Electronic databases were searched. Eligible studies included investigations of efficacy and safety of anti-PD-1/PD-L1 or anti-CTLA-4 agents in patients with CRC. Corresponding indicators were calculated. Results: A total of 15 articles were included. The pooled objective response rate, overall survival rate, progression-free survival rate and adverse event rate were 33, 56, 46 and 59%, respectively. The objective response rates for CRC with deficient mismatch repair and CRC with proficient mismatch repair were 43 and 3%, respectively, in patients treated with PD-1 inhibitors. Conclusion: The authors’ study indicates that PD-1/PD-L1 inhibitors manifest promising clinical responses in the treatment of CRC with deficient mismatch repair with acceptable treatment-related adverse events.</p

Table_1_Whether interstitial space features were the main factors affecting sediment microbial community structures in Chaohu Lake.DOCX

Sediments cover a majority of Earth’s surface and are essential for global biogeochemical cycles. The effects of sediment physiochemical features on microbial community structures have attracted attention in recent years. However, the question of whether the interstitial space has significant effects on microbial community structures in submerged sediments remains unclear. In this study, based on identified OTUs (operational taxonomic units), correlation analysis, RDA analysis, and Permanova analysis were applied into investigating the effects of interstitial space volume, interstitial gas space, volumetric water content, sediment particle features (average size and evenness), and sediment depth on microbial community structures in different sedimentation areas of Chaohu Lake (Anhui Province, China). Our results indicated that sediment depth was the closest one to the main environmental gradient. The destruction effects of gas space on sediment structures can physically affect the similarity of the whole microbial community in all layers in river dominated sedimentation area (where methane emits actively). However, including gas space, none of the five interstitial space parameters were significant with accounting for the microbial community structures in a sediment layer. Thus, except for the happening of active physical destruction on sediment structures (for example, methane ebullition), sediment interstitial space parameters were ineffective for affecting microbial community structures in all sedimentation areas.</p

Data_Sheet_1_Whether interstitial space features were the main factors affecting sediment microbial community structures in Chaohu Lake.CSV

Sediments cover a majority of Earth’s surface and are essential for global biogeochemical cycles. The effects of sediment physiochemical features on microbial community structures have attracted attention in recent years. However, the question of whether the interstitial space has significant effects on microbial community structures in submerged sediments remains unclear. In this study, based on identified OTUs (operational taxonomic units), correlation analysis, RDA analysis, and Permanova analysis were applied into investigating the effects of interstitial space volume, interstitial gas space, volumetric water content, sediment particle features (average size and evenness), and sediment depth on microbial community structures in different sedimentation areas of Chaohu Lake (Anhui Province, China). Our results indicated that sediment depth was the closest one to the main environmental gradient. The destruction effects of gas space on sediment structures can physically affect the similarity of the whole microbial community in all layers in river dominated sedimentation area (where methane emits actively). However, including gas space, none of the five interstitial space parameters were significant with accounting for the microbial community structures in a sediment layer. Thus, except for the happening of active physical destruction on sediment structures (for example, methane ebullition), sediment interstitial space parameters were ineffective for affecting microbial community structures in all sedimentation areas.</p

Table_2_Whether interstitial space features were the main factors affecting sediment microbial community structures in Chaohu Lake.XLSX

Sediments cover a majority of Earth’s surface and are essential for global biogeochemical cycles. The effects of sediment physiochemical features on microbial community structures have attracted attention in recent years. However, the question of whether the interstitial space has significant effects on microbial community structures in submerged sediments remains unclear. In this study, based on identified OTUs (operational taxonomic units), correlation analysis, RDA analysis, and Permanova analysis were applied into investigating the effects of interstitial space volume, interstitial gas space, volumetric water content, sediment particle features (average size and evenness), and sediment depth on microbial community structures in different sedimentation areas of Chaohu Lake (Anhui Province, China). Our results indicated that sediment depth was the closest one to the main environmental gradient. The destruction effects of gas space on sediment structures can physically affect the similarity of the whole microbial community in all layers in river dominated sedimentation area (where methane emits actively). However, including gas space, none of the five interstitial space parameters were significant with accounting for the microbial community structures in a sediment layer. Thus, except for the happening of active physical destruction on sediment structures (for example, methane ebullition), sediment interstitial space parameters were ineffective for affecting microbial community structures in all sedimentation areas.</p

Full Spectrum Visible LED Light Activated Antibacterial System Realized by Optimized Cu₂O Crystals

Assisted by three-dimensional printing technology, we proposed and demonstrated a full spectrum visible light activated antibacterial system by using a combination of 500 nm sized Cu₂O crystals and light-emitting diode (LED) lamps. Further improved antibacterial ratios were achieved, for the first time, with pure Cu₂O for both Gram-positive bacteria and Gram-negative bacteria among all of the six different color LED lamps. For practical antibacterial applications, we revealed that the nonwoven fabric could act as excellent carrier for Cu₂O crystals and provide impressive antibacterial performance. Furthermore, integrated with our self-developed app, the poly­(ethylene terephthalate) film loaded with Cu₂O crystals also showed significant antibacterial property, thus making it possible to be applied in field of touch screen. The present research not only provided a healthier alternative to traditional ultraviolet-based sterilization but also opened an auto-response manner to decrease the rate of microbial contamination on billions of touch screen devices

Surface State Passivation and Optical Properties Investigation of GaSb via Nitrogen Plasma Treatment

GaSb is one of the most suitable semiconductors for optoelectronic devices operating in the mid-infrared range. However, the existence of GaSb surface states has dramatically limited the performance of these devices. Herein, a controllable nitrogen passivation approach is proposed for GaSb. The surface states and optical properties of GaSb were found to depend on the N passivation conditions. Varying the plasma power during passivation modified the chemical bonds of the GaSb surface, which influenced the emission efficiency. X-ray photoelectron spectroscopy was used to quantitatively demonstrate that the GaSb oxide layer was removed via treatment at a plasma power of 100 W. After nitrogen passivation, the samples exhibited enhanced emission. Free exciton emission was the main factor leading to this enhanced luminescence. An energy band model for the surface states is used to explain the carrier radiative recombination processes. This nitrogen passivation approach can suppress surface states and improve the surface quality of GaSb-based materials and devices. The enhancement in exciton-related emission by this simple approach is important for improving the performance of GaSb-based optoelectronic devices

Localized-State-Dependent Electroluminescence from ZnO/ZnS Core–Shell Nanowires–GaN Heterojunction

ZnO is a very important material for excitonic ultraviolet optoelectronic devices operating above room temperature due to its wide band gap and high exciton binding energy. In this paper, the influences of different degrees of the localized state on the photoluminescence and electroluminescence properties of the ZnO/ZnS core–shell nanowires–GaN heterojunction are systematically discussed. The physical model for radiative recombination of localized carriers was proposed to explain these phenomena. Our results indicate that surface-coating of ZnS nanoparticles on ZnO nanowires (NWs) is one of the effective ways to manipulate the localized states, and only the appropriate localized state will result in the optimal optoelectronic properties

Ultraviolet Electroluminescence from ZnS@ZnO Core–Shell Nanowires/p-GaN Introduced by Exciton Localization

We investigate the electroluminescence (EL) from light emitting diodes (LEDs) of ZnO nanowires/p-GaN structure and ZnS@ZnO core–shell nanowires/p-GaN structure. With the increase of forward bias, the emission peak of ZnO nanowires/p-GaN structure heterojunction shows a blue-shift, while the ZnS@ZnO core–shell nanowires/p-GaN structure demonstrates a changing EL emission; the ultraviolet (UV) emission at 378 nm can be observed. This discrepancy is related to the localized states introduced by ZnS particles, which results in a different carrier recombination process near the interfaces of the heterojunction. The localized states capture the carriers in ZnO nanowires and convert them to localized excitons under high forward bias. A strong UV emission due to localized excitons can be observed. Our results indicated that utilizing localized excitons should be a new route toward ZnO-based ultraviolet LEDs with high efficiency

The “Pure Marriage” between 3D Printing and Well-Ordered Nanoarrays by Using PEALD Assisted Hydrothermal Surface Engineering

For the first time, homogeneous and well-ordered functional nanoarrays were grown densely on the complex structured three-dimensional (3D) printing frameworks through a general plasma enhanced atomic layer deposition (PEALD) assisted hydrothermal surface engineering process. The entire process was free from toxic additives or harmful residues and, therefore, can meet the critical requirements of high-purity products. As a practical example, 3D customized earplugs were precisely manufactured according to the model of ear canals at the 0.1 mm level. Meanwhile, well-ordered ZnO nanoarrays, formed on the surfaces of these 3D printed earplugs, could effectively prevent the growth of five main pathogens derived from the patients with otitis media and exhibited excellent wear resistance as well. On the basis of both animal experiments and volunteers’ investigations, the 3D customized earplugs showed sound insulation capabilities superior to those of traditional earplugs. Further animal experiments demonstrated the potential of as-modified implant scaffolds in practical clinical applications. This work, exemplified with earplugs and implant scaffolds, oriented the development direction of 3D printing in biomedical devices, which precisely integrated customized architecture and tailored surface performance

The “Pure Marriage” between 3D Printing and Well-Ordered Nanoarrays by Using PEALD Assisted Hydrothermal Surface Engineering

For the first time, homogeneous and well-ordered functional nanoarrays were grown densely on the complex structured three-dimensional (3D) printing frameworks through a general plasma enhanced atomic layer deposition (PEALD) assisted hydrothermal surface engineering process. The entire process was free from toxic additives or harmful residues and, therefore, can meet the critical requirements of high-purity products. As a practical example, 3D customized earplugs were precisely manufactured according to the model of ear canals at the 0.1 mm level. Meanwhile, well-ordered ZnO nanoarrays, formed on the surfaces of these 3D printed earplugs, could effectively prevent the growth of five main pathogens derived from the patients with otitis media and exhibited excellent wear resistance as well. On the basis of both animal experiments and volunteers’ investigations, the 3D customized earplugs showed sound insulation capabilities superior to those of traditional earplugs. Further animal experiments demonstrated the potential of as-modified implant scaffolds in practical clinical applications. This work, exemplified with earplugs and implant scaffolds, oriented the development direction of 3D printing in biomedical devices, which precisely integrated customized architecture and tailored surface performance