胃食道逆流症における好酸球性食道炎の頻度とタイトジャンクション蛋白の変動に関する前向き研究

研究科: 千葉大学大学院医学薬学府学位:千大院医薬博甲第医1127号要約博士(医学)千葉大

Algorithm 1: Dynamic Time Warping.

<p>Algorithm 1: Dynamic Time Warping.</p

The illustration of MFCC normalization. In table header, ‘Fr’ represents time frame, and ‘Dim’ means dimension.

<p>A MFCC is represented by a matrix. This matrix is constituted by time frames where each time frame is represented by a dimensional vector. Therefore, each dimension has values, which will be normalized into the range between −1 and 1 after the MFCC normalization step.</p

Accuracy (%) by using original DTW on different (non)normalized dimensional MFCC.

<p>In the first column, numbers represent dimensions, ‘Norm’ means normalized MFCC, and ‘NonNorm’ means unnormalized MFCC.</p

The samples of clean and reverberant signals of audio “MinZhang”.

<p>The samples of clean and reverberant signals of audio “MinZhang”.</p

The illustration of one-against-all index (OAI) acquisition.

<p>Suppose that there are three training MFCCs. We take the node of training MFCC (bold and italic letter) as example. The is acquired by using all of the distances among nodes in and their aligned nodes. The is acquired by using all the distance between node in and its aligned nodes.</p

Recording Condition Description.

<p>Recording Condition Description.</p

Algorithm 2: Similarity Score of Normalized Training and Testing MFCC.

<p>Algorithm 2: Similarity Score of Normalized Training and Testing MFCC.</p

DTW accuracy (DTW Acc) and OAWDTW accuracy (OAWDTWAcc)(%) comparison, and OAWDTW relative reduction of error rate (OAWDTW RRER) (%) based on DTW.

<p>DTW accuracy (DTW Acc) and OAWDTW accuracy (OAWDTWAcc)(%) comparison, and OAWDTW relative reduction of error rate (OAWDTW RRER) (%) based on DTW.</p

Characterization and Drug Delivery Properties of OSA Starch-Based Nanoparticles Prepared in [C₃OHmim]Ac-in-Oil Microemulsions System

In this work, an enhanced starch-dissolving room-temperature ionic liquid 1-hydroxypropyl-3-methylimidazolium acetate ([C₃OHmim]­Ac) was tailor-made to serve as the polar phase in the formation of [C₃OHmim]­Ac/TX-100 + 1-butanol/cyclohexane (IL/O) microemulsion. Its superior solubility to starch was verified by the polarized-light microscope and turbidity test. Furthermore, a pseudoternary phase diagram, conductivity measurement, and dynamic light scattering (DLS) were used to analyze the phase behavior and microregion of IL/O microemulsion. On this basis starch nanoparticles with a mean diameter of 86.69 nm were successfully prepared in this novel IL/O microemulsion with octenyl succinic anhydride (OSA) maize starch as the raw material and epichlorohydrin as a cross-linker through microemulsion cross-linking reaction. For starch nanoparticles, Fourier transform infrared spectroscopy (FTIR) data demonstrated the formation of ester bonds, and cross-linking reaction in starch molecules and X-ray diffraction (XRD) disclosed the destruction of the crystal structure. In addition, scanning electron microscopy (SEM) intuitively revealed that OSA-modified starch nanoparticles possessed good dispersibility, nanoscaled size, and a relatively concentrated size distribution. Finally, drug loading and releasing properties of starch nanoparticles were investigated with indomethacin as a drug model