Syntheses, Structures, and Magnetic Properties of Two Novel Three-Dimensional Frameworks Built from M₄O₄ Cubanes and Dicyanamide Bridges

Two novel coordination polymers Ni4(CH3O)4(CH3OH)4(dca)4 (1) and Co4(CH3O)4(CH3OH)4(dca)4 (2) have been synthesized by solvethermal reaction. X-ray single-crystal analysis reveals that the two complexes are isostrutural and possess 3D frameworks that are built from the M4O4(M= Ni (1) and Co (2)) cubanelike building blocks linked by dicyanamide (dca) bridges. The temperature dependence of the magnetic susceptibility was measured and the DC experiment data were fitted using the Heisenberg spin Hamiltonian

Syntheses, Structures, and Magnetic Properties of Two Novel Three-Dimensional Frameworks Built from M₄O₄ Cubanes and Dicyanamide Bridges

Two novel coordination polymers Ni4(CH3O)4(CH3OH)4(dca)4 (1) and Co4(CH3O)4(CH3OH)4(dca)4 (2) have been synthesized by solvethermal reaction. X-ray single-crystal analysis reveals that the two complexes are isostrutural and possess 3D frameworks that are built from the M4O4(M= Ni (1) and Co (2)) cubanelike building blocks linked by dicyanamide (dca) bridges. The temperature dependence of the magnetic susceptibility was measured and the DC experiment data were fitted using the Heisenberg spin Hamiltonian

Syntheses, Structures, and Magnetic Properties of Two Novel Three-Dimensional Frameworks Built from M₄O₄ Cubanes and Dicyanamide Bridges

Two novel coordination polymers Ni4(CH3O)4(CH3OH)4(dca)4 (1) and Co4(CH3O)4(CH3OH)4(dca)4 (2) have been synthesized by solvethermal reaction. X-ray single-crystal analysis reveals that the two complexes are isostrutural and possess 3D frameworks that are built from the M4O4(M= Ni (1) and Co (2)) cubanelike building blocks linked by dicyanamide (dca) bridges. The temperature dependence of the magnetic susceptibility was measured and the DC experiment data were fitted using the Heisenberg spin Hamiltonian

Di-, Tetra-, and Hexanuclear Hydroxy-Bridged Copper(II) Cluster Compounds: Syntheses, Structures, and Properties

Self-assembly reactions of copper (II) ions, dicarboxylate (adipate or terephthalate) and terminal ligands (4,4′-bipyridine or phenanthroline) yielded three hydroxy-bridged Cu(II) cluster complexes: [Cu(phen)(OH)(H2O)]2·(C8H4O4)·8H2O (1), [Cu4(bpy)4(OH)4(H2O)2]·(C8H4O4)2·6H2O (2) and [Cu6(bpy)6(OH)6(H2O)2]·(C6H8O4)3·23H2O (3) (phen = phenanthroline, bpy = 2,2′-bipyridine, C8H6O4 = terephthalic acid, C6H10O4 = adipic acid). Single crystal X-ray diffraction analyses reveal that complex 1 is a discrete dinuclear Cu2O2 motif, 2 presents a discrete chairlike tetranuclear copper(II) Cu4O4 core formed by two Cu2O2 units, and 3 assumes a discrete hexameric copper(II) Cu6O6 cluster consisting of three Cu2O2 units. The polynuclear structures are generated from the Cu(II) ions linked by the µ2- and/or µ3-OH groups. In 1−3, all Cu(II) ions show square pyramidal coordination geometry, and the dicarboxylate ions act as counteranions to keep the whole structure neutral. Thermogravimetric analyses (TGA) and magnetic properties of 1−3 were studied, respectively

Layer-by-Layer Assembled Janus Microcapsules

Layer-by-Layer Assembled Janus Microcapsule

Supplemental Material - High-Throughput Drug Screen for Potential Combinations With Venetoclax Guides the Treatment of Transformed Follicular Lymphoma

Supplemental Material for High-Throughput Drug Screen for Potential Combinations With Venetoclax Guides the Treatment of Transformed Follicular Lymphoma by Zhifeng Li, Guangchao Pan, Mengya Zhong, Li Zhang, Xingxing Yu, Jie Zha, and Bing Xu in International Journal of Toxicology.</p

Pd-Catalyzed Cyanation of a Bromoaryl Carboxylate En Route to Etrumadenant: Robust Process with Low Catalyst Loading Enabled by Preactivation

Palladium-catalyzed cyanation of aryl bromides is a powerful approach to install a functional group commonly found in active pharmaceutical ingredients starting from readily available precursors. The development of a robust cyanation of a bromo benzoic acid to generate an intermediate en route to etrumadenant is described. Full conversion with catalyst loading as low as 0.13 mol % was enabled by study of the catalyst preactivation step, which was affected by trace water levels. Details of the scale-up of this process to the hundred-kilogram batch size are included

Discovery of bi-4-methoxycarbonyl-2-quinolone and evaluation of its anti-inflammatory and anti-cancer activity <i>in vitro</i>

A novel alkaloid with a hexa-tetra-hexa-cyclic skeleton, Bi-4-methoxycarbonyl-2-quinolone (1), was discovered during the investigation of Brucea javanica. Additionally, six known alkaloids (2–7) were also found. The chemical structures of these compounds were identified using HRESIMS and 1D and 2D NMR spectroscopic analysis. Additionally, the absolute configuration of the new compound 1 was determined through X-ray single crystal diffraction. Compound 1 exhibited significant anti-inflammatory activity in RAW264.7 cells and demonstrated promising anti-cancer effects in Lewis cells.</p

Meta-analysis of the overall response rate in the PD-1 antibody monotherapy groups and the other treatment groups.

PD-1 antibody treatment was associated with a higher overall response rate.</p