Myeloperoxidase Polymorphism, Menopausal Status, and Breast Cancer Risk: An Update Meta-Analysis

<div><p>Myeloperoxidase (MPO) is a metabolic/oxidative lysosomal enzyme secreted by reactive neutrophils at the sites of inflamed organs and tissues during phagocytosis. MPO has been either directly or indirectly linked to neoplasia, which is a well-established risk factor for many types of cancer. A large number of studies have reported the role of MPO G-463A polymorphism regarding breast-cancer risk. However, the published findings are inconsistent. Therefore, we conducted a meta-analysis to determine more precise estimations for the relationship. Eligible studies were identified by searching several electronic databases for relevant reports published before June 2012. According to the inclusion criteria and exclusion criteria, a total of five eligible studies were included in the pooled analyses. When the five eligible studies concerning MPO G-463A polymorphism were pooled into this meta-analysis, there was no evidence found for a significant association between MPO G-463A polymorphism and breast-cancer risk in any genetic model. We also categorized by ethnicity (Caucasian or Asian) for subgroup analysis; according to this subgroup analysis, we found no significant association between MPO G-463A polymorphism and breast-cancer risk in any genetic model. However, in the stratified analysis for the premenopausal group, women carrying the AA genotype were found to have a significantly reduced risk (OR = 0.56, 95% CI 0.34–0.94, p = 0.027). Under the recessive model, there was a significant association between MPO G-463A polymorphism and breast-cancer risk (OR = 0.57, 95% CI 0.34–0.93, p = 0.025). We conclude that MPO-G463A polymorphism might not be a good predictor of breast-cancer risk, though menopausal status modified women’s risk of developing breast cancer.</p></div

Publication bias tests for comparisons involving the MPO polymorphism.

<p>Publication bias tests for comparisons involving the MPO polymorphism.</p

Additional file 1 of Mediating effect of body fat percentage in the association between ambient particulate matter exposure and hypertension: a subset analysis of China hypertension survey

Supplementary Material

Flow chart of meta-analysis.

<p>Flow chart of meta-analysis.</p

Genetic polymorphism of MPO and breast cancer risk in pre-menopausal women.

a<p><i>P</i> value for heterogeneity based on Q test.</p

Meta-analysis of OR for MPO polymorphism associated with breast cancer in pre-menopausal women (AA versus GG).

<p>Meta-analysis of OR for MPO polymorphism associated with breast cancer in pre-menopausal women (AA versus GG).</p

Genetic polymorphism of MPO and breast cancer risk.

a<p><i>P</i> value for heterogeneity based on Q test.</p

Scale for methodological quality assessment.

<p>Scale for methodological quality assessment.</p

Meta-analysis of OR for MPO polymorphism no associated with breast cancer in post-menopausal women (AA versus GG).

<p>Meta-analysis of OR for MPO polymorphism no associated with breast cancer in post-menopausal women (AA versus GG).</p

Genetic polymorphism of MPO and breast cancer risk in post-menopausal women.

a<p><i>P</i> value for heterogeneity based on Q test.</p