Cell-Permeable Au@ZnMoS₄ Core–Shell Nanoparticles: Toward a Novel Cellular Copper Detoxifying Drug for Wilson’s Disease

A layer-by-layer self-assembly method leads to the formation of Au@ZnMoS₄ core–shell nanoparticles (NPs). The PEGylated Au@ZnMoS₄ NPs are highly water-dispersible, exhibit no cytotoxicity, and can penetrate the cell membrane to selectively remove copper­(I) ions from HepG2 cells in the presence of other endogenous and biologically essential metal ions, including Mg²⁺, Ca²⁺, Mn²⁺, and Fe²⁺, demonstrating their potential as a novel intracellular copper detoxifying agent

One-Pot Synthesis of Ferrocenyl Ketones Containing Biaryls and 6‑Aryl-2-ferrocenyl­quinolines via Ir/Pd-Cocatalyzed α‑Alkylation/Suzuki Reaction

An efficient PPh₃-cyclometalated iridium­(III) benzo­[<i>h</i>]­quinoline hydride <b>1</b>/Pd­(OAc)₂-cocatalyzed three-component α-alkylation/Suzuki reaction has been developed. The three-component reaction of 4-bromobenzyl alcohol, acetylferrocene, and arylboronic acids gives ferrocenyl ketones containing biaryls in moderate to good yields. This method was successfully applied to a one-pot synthesis of 6-aryl-2-ferrocenyl quinolines, using (2-amino-5-bromo­phenyl)­methanol instead of 4-bromo­benzyl alcohol

One-Pot Synthesis of Ferrocenyl Ketones Containing Biaryls and 6‑Aryl-2-ferrocenyl­quinolines via Ir/Pd-Cocatalyzed α‑Alkylation/Suzuki Reaction

An efficient PPh₃-cyclometalated iridium­(III) benzo­[<i>h</i>]­quinoline hydride <b>1</b>/Pd­(OAc)₂-cocatalyzed three-component α-alkylation/Suzuki reaction has been developed. The three-component reaction of 4-bromobenzyl alcohol, acetylferrocene, and arylboronic acids gives ferrocenyl ketones containing biaryls in moderate to good yields. This method was successfully applied to a one-pot synthesis of 6-aryl-2-ferrocenyl quinolines, using (2-amino-5-bromo­phenyl)­methanol instead of 4-bromo­benzyl alcohol

Radiosonde measurements from station Lindenberg (2013-09)

<p>Univariate and multivariate COX proportional hazard analyses of prognostic factors for overall survival in GBM patients.</p

Image_1_Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer.jpeg

ObjectiveTo understand the characteristics of genetic mutation in multiple primary lung cancer so as to guide clinical decisions in targeted therapy.MethodsWe analyzed a total of 265 tumors from 111 patients who underwent surgery for multiple lung cancers. Individual tumors were subjected to histological evaluation and gene mutation analysis using ABI 7500 Fluorescence quantitative PCR.ResultsIn this study, we analyzed demographic and clinical parameters such as age, gender, smoking, alcohol consumption, pathological type, number of nodules, and other details of 111 patients with early multiple primary lung cancer. We also compared the clinicopathologic characteristics of different populations based on the gene mutation status of pulmonary nodules. Subsequently, we performed a clinicopathological analysis of all 265 pulmonary nodules from these patients. Results showed significant differences in clinicopathological features of pulmonary nodules in different genetic mutations.ConclusionThis study revealed the gene mutation characteristics and clinicopathological features in early multiple primary lung cancer. We found that the gene mutation status between different nodules in patients with early multiple primary lung cancer was inconsistent in most cases. Therefore, the use of targeted therapy based on the genetic sequencing of only one nodule, is unreliable. We hope this study can be helpful in guiding clinical treatment decisions.</p

Correlation of serum levels of three miRNAs with clinicopathological factors in GBM patients.

<p>Correlation of serum levels of three miRNAs with clinicopathological factors in GBM patients.</p

Validation of serum levels of miR-451a, miR-485-3p and miR-4298 by qRT-PCR in GBM patients.

<p>The average serum levels of the 3 miRNAs in GBM patients (n = 24) were compared with those in healthy volunteer controls (n = 12). <b>(A)</b> serum level of miR-451a in GBM patients is significantly higher than that in healthy controls. <b>(B)</b> serum level of miR-485-3p in GBM patients is significantly lower than that in healthy controls. <b>(C)</b> serum level of miR-4298 in GBM patients is significantly lower than that in healthy controls. The serum levels of the 3 miRNAs in GBM patients are in concordance with the results of microarray analysis. miRNA levels in each sample were normalized to miR-16. ΔCt = mean value of Ct (reference miRNA16)–mean value of Ct (target miRNA).</p

Comparison of overall survival (OS) and progression-free survival (PFS) of the GBM patients with lowand high levels of serum miR-451a, miR-485-3p and miR-4298.

<p><b>(A)</b> There is no difference of survivals (OS and PFS) between patients with a low and high level of serum miR-451a <b>(B)</b> Patients with a low level of serum miR-485-3p had significantly shorter OS (P = 0.023) and PFS (P = 0.004) than those with a high level. <b>(C)</b> There is no difference of survivals (OS and PFS) between patients with a low and high level of serum miR-4298.</p

Aerobic Oxidation of Alcohols and the Synthesis of Benzoxazoles Catalyzed by a Cuprocupric Coordination Polymer (Cu⁺‑CP) Assisted by TEMPO

A Cu⁺-CP based on the tetranuclear unit {[(HSQPA)₂Cu₄(bipy)₄]·2H₂O}_<i>n</i>·2<i>n</i>H₂O has been constructed through Cu²⁺ salt, 2-(sulfonylquinlium-8-yloxy)­phthalic acid (H₃SQPA), and 4,4′-bipyridine (bipy). This Cu⁺-CP combined with 2,2,6,6-tetramethylpiperidine-1-oxyl as the cocatalyst is an effective catalyst for aerobic oxidation of alcohols and the synthesis of benzoxazoles and can be recycled at least four times without losing its catalytic activity

Direct α‑Arylation of α‑Amino Carbonyl Compounds with Indoles Using Visible Light Photoredox Catalysis

A general and mild method for the construction of functionalized 2-(1<i>H</i>-indol-3-yl)-2-amino-carbonyl compounds was achieved, which represents the first example of direct α-arylation of α-amino carbonyl compounds with indoles using the visible light photoredox catalysis strategy