A romantika-kutatás legújabb fejleményei

<p>Funnel Plot Illustrating the Lack of Publication Bias in the Meta-analysis for CSS (A), RFS (B), OS (C), and the CSS Subgroup Analysis Comparing BC and UTUC (D).</p

Additional file 1 of Comparative efficacy of different treatments for menstrual migraine: a systematic review and network meta-analysis

Additional file 1

Additional file 2 of Comparative efficacy of different treatments for menstrual migraine: a systematic review and network meta-analysis

Additional file 2

Additional file 1 of Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

Additional file 1: The plots of MR analysis results

Data_Sheet_1_Comparison of the Effectiveness of Various Drug Interventions to Prevent Etomidate-Induced Myoclonus: A Bayesian Network Meta-Analysis.ZIP

BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems. Currently, there is an increasing number of drugs for preventing etomidate-induced myoclonus (EM). However, direct comparisons of various drugs are lacking, and this interferes with clinical decision-making. Our network meta-analysis (NMA) aimed to compare the efficacy of different drugs for the prevention of moderate-to-severe general myoclonus.MethodsUsing several biomedical databases, randomized controlled trials (RCTs) published in English from inception to August 22, 2021 were searched. Among the various interventions, we selected nine types of intervention drugs (dexmedetomidine, etomidate, lidocaine, NMDA receptor antagonist, κ opioid receptor agonist, μ opioid receptor agonist, muscle relaxant, gabapentin, and midazolam) for comparison, according to the number of studies. Bayesian NMA was performed using STATA16 and R softwares. The relative risk of EM was assessed using risk ratios (RRs) and the corresponding 95% confidence intervals (CI).ResultsA total of 31 RCTs (3209 patients) were included. NMA results showed that, compared with a placebo, etomidate (RR 4.0, 95%CI 2.1–7.8), κ opioid receptor agonist (RR 2.9, 95%CI 1.9–4.6), μ opioid receptor agonist (RR 3.1, 95%CI 2.3–4.3), NMDA receptor antagonist (RR 1.7, 95%CI 1.0–2.8), dexmedetomidine (RR 2.4, 95%CI 1.5–3.9), lidocaine (RR 2.1, 95%CI 1.2–3.9), and midazolam (RR 2.2, 95%CI 1.5–3.2) can significantly reduce the risk of EM. In contrast, the effects of muscle relaxants (RR 2.1, 95%CI 0.81–5.3) and gabapentin (RR 2.8, 95%CI 0.92–9.3) were inconclusive. Further subgroup analyses showed that preoperative low-dose etomidate, μ-opioid receptor agonist, and κ-opioid receptor agonist were significantly better than other interventions in the prevention of moderate to severe EM.ConclusionPreoperative use of small doses of etomidate or opioids may be the most effective way to avoid EM, especially moderate and severe EM, which makes anesthesia induction safer, more stable, and aligns better with the requirements of comfortable medicine.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], [CRD4202127706].</p

Funnel plot of the 29 studies included in the meta-analysis.

<p>Funnel plot of the 29 studies included in the meta-analysis.</p

Key features of the included studies.

<p>Key features of the included studies.</p

Low-Temperature Steam Reforming of Toluene and Biomass Tar over Biochar-Supported Ni Nanoparticles

Developing efficient, inexpensive, in situ tar reforming technologies under mild conditions is an important practical aspect of biomass gasification. In this study, a series of biochar-supported Ni catalysts (Ni/BC) were prepared via a simple one-step pyrolytic approach and first explored for steam reforming of toluene as a tar model compound at a relatively low temperature of 600 °C. The as-prepared catalysts can be directly used without a further reduction process. The abundant surface oxygen containing groups of the starting biomass and the high porosity of Ni/BC assisted with the dispersion of the Ni nanoparticles. The in situ generating process of metallic Ni nanoparticles via carbothermal reduction was manipulated to modulate the Ni particle size. A size-dependent behavior was observed, wherein 5Ni-600/BC (pyrolyzed at 600 °C, 5% Ni loading) with the smallest Ni particle size (4.2 nm) showed superior catalytic performance in terms of the initial intrinsic activity (turnover frequency value of 1.64 s–1) and stability over others, indicating the positive role of small particles with more corner and step sites, which was further proved by DFT calculations. In addition, 5Ni-600/BC was found to be effective in the steam reforming of real biomass tar by reducing both the tar amount and the molecular weight

Forest plot of the 29 studies included in the meta-analysis.

<p>Forest plot of the 29 studies included in the meta-analysis.</p

Prevalence of Suicide Attempts among College Students in China: A Meta-Analysis

<div><p>Background</p><p>Suicide is the leading cause of death among 15–34 year olds in China, but no national data are available on the suicide and suicide attempts rates of college students, a sub-group of youth with 23 million. Several studies have reported the prevalence of suicide attempts among college students, however, no meta-analysis pooling the prevalence of suicide attempts is found.</p><p>Objective and Methods</p><p>This study aims to estimate the pooled prevalence of suicide attempts among college students in China. The relevant studies up to August 2014 were systematically searched via electronic databases (PubMed-Medline, Embase, Chinese Wanfang database, Chinese National Knowledge Infrastructure and Chinese VIP database). We only selected original articles that either reported the prevalence of suicide attempts or sufficient data for calculating the prevalence.</p><p>Results</p><p>A total of 29 eligible studies, with 88,225 college students, were finally included. The maximum and minimum reported prevalences of suicide attempts among college students in China were 0.4% and 10.5%, respectively. The pooled prevalence of suicide attempts was 2.8% (95%<i>CI</i>: 2.3%–3.3%). Subgroup analyses showed that the pooled estimate of prevalence of life time suicide attempts was 2.7% (95%<i>CI</i>: 2.1%–3.3%), and 12-month suicide attempts was 2.9% (95%<i>CI</i>: 2.0%–3.8%). The prevalence for males was 2.4% (95%<i>CI</i>: 1.8%–3.0%), and for females was 2.7% (95%<i>CI</i>: 1.9%–3.7%). The prevalences among college students in grade 1 through 4 were 2.8% (95%<i>CI</i>: 1.7%–3.8%), 1.8% (95%<i>CI</i>: 1.2%–2.3%), 2.0% (95%<i>CI</i>: 0.8%–3.1%), and 2.9% (95%<i>CI</i>: 0.1%–6.7%), respectively. The prevalences among college students from rural and urban areas were 5.1% (95%<i>CI</i>: 2.8%–7.5%) and 3.7% (95%<i>CI</i>: 1.4%–5.9%), respectively.</p><p>Conclusions</p><p>2.8% prevalence of suicide attempts and more than 600,000 suicide attempters among college students indicate that suicide attempt among college students is an important public health problem in China. More attention should be paid to the current situation.</p></div