A new 1D Zn(II) coordination polymer containing pyridinyl-imidazolyl ligand: crystal structure and protective effect on dermatitis by reducing the inflammatory level

A new coordination polymer of [Zn(bdc)(bimb)](DMF)(H2O)2 (1, H2bdc = 1,4-dicarboxybenzene, bimb = 6,6'-bis(1H-benzo[d]imidazol-2-yl)-2,2'-bipyridine) has been successfully synthesized by reaction of Zn(NO3)2·6H2O, H2bdc and bimb in a mixed solvent of DMF and water at 80 °C for three days. Furthermore, an ultrasound synthesis technique has been implemented to reduce the particle size of the complex 1 to generate nanoscale 1 (denoted as nano 1). We constructed the dermatitis mice model with DNFB-induction. The scoring index of the AD lesion in mice was evaluated after nano 1 treatment and the ELISA was used to measure the level of inflammatory medium after nano 1 exposure.</p

Structural diversity and anti-lung cancer activity evaluation of two Co(II) and Cu(II) containing mixed-ligand coordination polymers

In this study, we report the synthesis and structural characterization of two new Co(II) and Cu(II) containing coordination polymers {[Co2(btc)(mbtz)2]·7H2O}n (1), [Cu2(btc)(mbtz)2]n (2) by using the N donor ligand 1,3-bis(1H-1,2,4-triazol-1-ylmethyl)benzene (mbtz) and the O-donor ligand 1,2,4,5-benzenetetracarboxylic acid (H4btc) as the co-linkers. Furthermore, a sonochemical process was used to produce the nanostructures of coordination polymers 1 and 2. Then, we evaluated the anti-viability of nano 1 and 2 on LTEP lung cancer cells. And the Annexin V-FITC/PI staining was performed to detect the apoptosis induced by nano 1 and 2 on LTEP cells. The ROS level in LTEP cells was measured by DCFH-DA assay.</p

Synthesis, characterization and anti-lung cancer activity of two transition metal coordination polymers based on the imidazole-containing ligands

This work presents the synthesis and characterization of two new transition metal coordination polymers [Co(tib)2](NO3)2 (1, tib = 1,3,5-tris(1-imidazolyl)benzene) and [Cd4(bib)5(HCOO)8](DMF)3 (2, bib = 4,4′-bisimidazolylbiphenyl) have been successfully prepared by using two imidazole-containing ligands with different geometers. All structures have been fully elucidated by single-crystal X-ray diffraction along with the elemental analysis. The structural solution and refinement results based on the crystal data collected at room temperature reveal that complex 1 shows a 2D layered structure with a binodal (3,6)-connected kgd topological net, while complex 2 also demonstrates a 2D framework but reflecting a 4-connected sql topological net. Furthermore, the anti-lung cancer activity of the two complexes has been studied via the Cell Counting Kit-8 (CCK-8) assay along with the corresponding action mechanism.</p

Two new Bi(III) and Ce(III) chelates incorporating 1,10-phenanthroline-2,9-dicarboxylic acid: structure elucidation and anti-lung cancer activity study

Reactions of 1,10-phenanthroline-2,9-dicarboxylic acid (H2phenda) with Bi(NO3)3·5H2O or Ce(NO3)3·6H2O under solvothermal conditions yielded two new coordination complexes Bi(NO3)2(phenda)2(H2O)3 (1) and [Ce(SO4)(phenda)2(H2O)6](H2O)2 (2). The structures of the two complexes have been elucidated via elemental analyses and single crystal X-ray diffraction analysis. The results show that complex 1 is a discrete binuclear structure based on two seven-coordinated Bi(III) ions while complex 2 is a 1D v-shape chain structure based on two nine-coordinated Ce(III) ions. Furthermore, the anti-lung cancer activity of the complexes has been evaluated via the Cell Counting Kit-8 (CCK-8) assays.</p

Two mixed-ligand coordination polymers: Structural insights and treatment effect on atherosclerosis by regulating the miRNA-9 mediated NF-κB signaling pathway

By employment of a mixed-ligand strategy, two coordination polymers were synthesized via the hydrothermal approach utilizing two positionally isomeric carboxylic acid ligands 1,4-benzenedicarboxylic acid (1,4-H2BDC) and 1,3-benzenedicarboxylic acid (1,3-H2BDC) as well as one flexible ligand of bis(pyridyl-tetrazole) (3-bptzp = 1,4-bis(5-(3-pyridyl)tetrazolyl)propane), and their chemical formulae are [Co(3-bptzh)(1,3-BDC)] for complex 1 and [Ni(3-bptzp)(1,4-BDC)] for complex 2. The two complexes were characterized via diffraction of single crystal X-ray and the analysis of element. Furthermore, the treatment effect of the two compounds on atherosclerosis was assessed and specific mechanism was discussed. Firstly, the real time RT-PCR was performed to detect the relative expression of the miRNA-9 and NF-κB after complexes treatment. Next, the Dual-Luciferase reporter assay was conducted for the detection of the interaction between miRNA-9 and NF-κB.</p

Gene parity plot analysis of AnpeNPV with HycuNPV, EppoNPV, AcMNPV, RoNPV, BmNPV, CfDEFNPV, MacoNPV A and XcGV

<p><b>Copyright information:</b></p><p>Taken from "Complete sequence and organization of nucleopolyhedrovirus, a -rich baculovirus"</p><p>http://www.biomedcentral.com/1471-2164/8/248</p><p>BMC Genomics 2007;8():248-248.</p><p>Published online 24 Jul 2007</p><p>PMCID:PMC1976136.</p><p></p> The axes represent the relative position of each ORF along the genome in kb. The dots represent ORFs. (a) The organization of the genome collinear to that of AnpeNPV. (b) The organization of the genome partially collinear to that of AnpeNPV. There were two cluster regions in which gene order was the reverse direction and arrows indicated the clusters. (c) The organization of the genome partially collinear to that of AnpeNPV. There was one cluster in which gene order was in inverse direction and arrows indicated the cluster. (d)There was not a collinear relationship between AnpeNPV and MacoNPV A, XcGV