Additional file 1 of Treating non-responders: pitfalls and implications for cancer immunotherapy trial design

Additional file 1: A simulation study to investigate the cause of NPH patterns

Internationalization of the construction industry in the global value chain

The construction sector plays a significant role in national economic development and accounts for a dominant portion of national economic growth. The international construction industry’s development has been explored from the perspective of the economy. Internationalization improves awareness about participation in international trade activities. This paper aims to quantify the internationalization of the construction industry in the global value chain. The sectoral participation index and interaction index are conducted to evaluate the internationalized degree of the construction industries. In the results, the distribution of the backward participation indices shows nearly all countries’ internationalization processes were still at the stage of benefiting from primary resources. The forward support index is easily influenced by the scale effect. The backward independence index accounts for a small percentage of national imports measured by value added. The main source of value-added supply was the local construction sector. This study proposes a comprehensive indicator to quantify the internationalization of the construction industries in the sight of national and global points. The references have a positive value for policymakers in the management of value-added flows in the international market and adjustment of the foreign trade environment

Data_Sheet_1_Profiling Phenolic Composition in Pomegranate Peel From Nine Selected Cultivars Using UHPLC-QTOF-MS and UPLC-QQQ-MS.pdf

Pomegranate is widely cultivated across China, and the phenolics in its peel are principal components associated with health benefits. Ultra-high performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer (UHPLC-QTOF-MS) and ultra-performance liquid chromatography coupled to a triple quadrupole mass spectrometer (UPLC-QQQ-MS) were used in this study, aiming at profiling the total phenolic composition in pomegranate peel from nine selected cultivars in 7 production areas. Sixty-four phenolic compounds were identified or annotated, and 23 of them were firstly reported in pomegranate peel. Principal component analysis (PCA) plots show differences and similarities of phenolics among nine cultivars. Furthermore, 15 phenolic compounds were quantified with the standards, and punicalagin, ellagic acid, gallocatechin, punicalin, catechin, and corilagin were found to be dominant. Punicalagin weighed the highest content (28.03–104.14 mg/g). This study can provide a deeper and more detailed insight into the phenolic composition in pomegranate peel and facilitate the health-promoting utilization of phenolics.</p

Preparation and Characterization of Maillard Reaction Products from a Trinary System Composed of the Soy Protein Isolate, Chitosan Oligosaccharide, and Gum Arabic

To extend the application of chitosan oligosaccharide (COS) in complex coacervation between the soy protein isolate (SPI) and gum Arabic (GA), Maillard reaction among SPI, COS, and GA was induced under different conditions. High-performance gel permeation chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis illustrated that products with high molecular weights (1.17 × 106 and 2.79 × 106 Da) were generated in the trinary system, and the Maillard reaction promoted the cross-linking of SPI, COS, and GA. The Maillard reaction was observed the most under conditions where SPI, COS, and GA (4:2:4, w/w) were kept at 80 °C for 12 h, and the results of thermogravimetry indicated that Maillard reaction products (MRPs) with the best thermal stability, which were positively charged, were generated. The results revealed that the extent of Maillard reaction was enhanced with the increase of time SPI being involved in the complex rather than GA. X-ray diffraction and Fourier transform infrared analysis indicated that Maillard reactions between SPI, COS, and GA under different conditions did not impact the crystal particle structures among them. Even though the extent of Maillard reaction among SPI, COS, and GA was lower than that between SPI and COS, MRPs with various viscoelastic properties were obtained under different conditions. Thus, as one kind of difunctional reactant in Maillard reaction, COS could react with either proteins or polysaccharides, and the MRPs have potential utilization in the food industry

Tunable Morphology of the Self-Assembled Organic Microcrystals for the Efficient Laser Optical Resonator by Molecular Modulation

Organic single-crystalline micro/nanostructures can effectively generate and carry photons due to their smooth morphologies, high photoluminescence quantum efficiency, and minimized defects density and therefore are potentially ideal building blocks for the optical circuits in the next generation of miniaturized optoelectronics. However, the tailor-made organic molecules can be generally obtained by organic synthesis, ensuring that the organic molecules aggregate in a specific form and generate micro/nanostructures with desirable morphology and therefore act as the efficient laser optical resonator remains a great challenge. Here, the molecular modulation of the morphology on the laser optical resonator properties has been investigated through the preparation of the elongated hexagonal microplates (PHMs) and the rectangular microplates (ORMs), respectively, from two model isomeric organic molecules of 1,4-bis­(4-methylstyryl)­benzene (<i>p</i>-MSB) and 1,4-bis­(2-methylstyryl)­benzene (<i>o</i>-MSB). Significantly, fluorescence resonance phenomenon was only observed in the individual ORM other than the PHM. It indicates that the rectangular resonators possess better light-confinement property over the elongated hexagonal resonators. More importantly, optically pumped lasing action was observed in the <i>o</i>-MSB rectangular morphology microplates resonator with a high <i>Q</i> ≈ 1500 above a threshold of ∼540 nJ/cm². The excellent optical properties of these microstructures are associated with the morphology, which can be precisely modulated by the organic molecular structure. These self-assembled organic microplates with different morphologies can contribute to the distinct functionality of photonics elements in the integrated optical circuits at micro/nanoscale

The architecture of CCRec.

Depicts the three main components of CCRec: topic clustering and researcher partition, random walk, similarity calculation and top-N recommendation.</p

Statistics of data after topic clustering and researcher partition.

<p>Statistics of data after topic clustering and researcher partition.</p

Performance of CCRec, ACRec, CNRec, TBRec and RWR on most potential collaborators recommendation.

<p>The abscissas denote the length of recommendation list. The ordinates represent the values of precision, recall and F1 respectively.</p

Organic-Nanowire–SiO₂ Core–Shell Microlasers with Highly Polarized and Narrow Emissions for Biological Imaging

Development of luminescence probes with polarized and narrow emissions simultaneously is helpful for removing multiply scattered light and enables multiplexing detection, but it remains challenging to use conventional organic dyes, fluorescence proteins, and quantum dots. Here, we demonstrated smart one-dimensional microlaser probes (MLPs) by coating a thin layer of silica shell on the surface of organic nanowires (ONWs) of 1,4-dimethoxy-2,5-di­[4′-(methyl­thio)­styryl]­benzene (TDSB), namely, ONW@SiO₂ core–shell structures. Different from the Fabry–Pérot (FP) cavity formed between two end-faces of semiconductor nanowires, whispering gallery mode (WGM) microresonators are built within the rectangular cross section of ONW@SiO₂ MLPs. This enables a lasing threshold as low as 1.54 μJ/cm², above which lasing emissions are obtained with a full width at half-maximum (fwhm) < 5 nm and a degree of polarization (DOP) > 83%. Meanwhile, small dimensions of ONW@SiO₂ MLPs with a side-length of ca. 500 nm and a length of 3–8 μm help to reduce their perturbations in living cells. With the help of mesoporous silica shells, which provide both high biocompatibility and good photostability, ONW@SiO₂ MLPs can be easily introduced into the cell cytoplasm through natural endocytosis. Using their narrow and highly polarized lasing emissions in vitro, we demonstrate that it is possible to tag individual cells using ONW@SiO₂ MLPs with high stability

Epitaxial Self-assembly of Binary Molecular Components into Branched Nanowire Heterostructures for Photonic Applications

We report a sequential epitaxial growth to prepare organic branched nanowire heterostructures (BNwHs) consisting of a microribbon trunk of 1,4-dimethoxy-2,5-di­[4′-(cyano)­styryl]­benzene (COPV) with multiple nanowire branches of 2,4,5-triphenylimidazole (TPI) in a one-pot solution synthesis. The synthesis involves a seeded-growth process, where COPV microribbons are grown first as a trunk followed by a seeded-growth of TPI nanowire branches at the pregrown trunk surfaces. Selected area electron diffraction characterizations reveal that multiple hydrogen-bonding interactions between TPI and COPV components play an essential role in the epitaxial growth as a result of the structural matching between COPV and TPI crystals. A multichannel optical router was successfully realized on the basis of the passive waveguides of COPV green photoluminescence (PL) along TPI nanowire branches in a single organic BNwH