Diagnostic criteria for the various thyroid diseases.

*<p>Reference ranges: FT3 3.1–6.8 pmol/L; FT4 12–22 pmol/L; TSH 0.27–4.2 mIU/L; TPOAb 0.0–34 U/ml; TgAb 0.0–115 U/ml; TRAb <5.00 U/L.</p

A summary of the samples collected and investigations performed in the general population and the two subgroups.

*<p>If two participants were from the same household, only one set of table salt and drinking water samples was collected per household.</p

Comparison of urine iodine concentrations (UICs) between euthyroid participants and those with thyroid disease.

*<p>As patients with hyperthyroidism or subclinical hyperthyroidism were not allowed to take iodine or foods with high iodine content by recommendation of their doctors, participants with a known history of hyperthyroidism or subclinical hyperthyroidism are excluded from this table.</p>#<p>A euthyroid participant was defined as one whose thyroid gland was normal both by the blood assays and by ultrasound.</p>1<p><i>P</i><0.05 compared with the normal population, (Wilcoxon test).</p

The urine iodine concentration (UIC) in the general population aged 5–69 years.

<p>The urine iodine concentration (UIC) in the general population aged 5–69 years.</p

Iodine concentration and the daily iodine intake for a reference man from 12 kinds of food.

*<p>Aquatic products: fish, shellfish, molluscs, kelp and seaweed.</p

Myers indexes of age heaping.

<p>Myers indexes of age heaping.</p

Goodness of fit test of age distributions of current sample (aged 20–69 yrs) and population in Shanghai in 2008.

<p>Degree of freedom: All values were greater than cut-off points in the whole, female and male samples.</p

Differential methylation patterns from clusters associated with glucose metabolism: evidence from a Shanghai twin study

Supplementary table</p

Additional file 1: of Chinese woodchucks with different susceptibility to WHV infection differ in their genetic background exemplified by cytochrome B and MHC-DRB molecules

Table S1. Basic information. Table S2. Primers used for PCR and RT-PCR. Table S3. The parameters of PCR reaction mix and the amplification cycles. Table S4. Distribution of cytochrome B alleles in Chinese woodchucks. Table S5. Distribution of MHC-DRB alleles in Chinese woodchucks. (ZIP 41 kb

Immunosuppressive Drugs Modulate the Replication of Hepatitis B Virus (HBV) in a Hydrodynamic Injection Mouse Model

<div><p>Hepatitis B virus (HBV) reactivation and recurrence are common in patients under immunosuppression and can be controlled by hepatitis B immunoglobulin, antivirals, and hepatitis B vaccine. However, the detailed analysis of HBV infection under immunosuppression is essential for the prophylaxis and therapy for HBV reactivation and recurrence. In this study, HBV replication and T cell responses were analyzed in a HBV-transfected mouse model under immunosuppressive therapy. During the treatment, HBV replication was at a high level in mice treated with dexamethasone, cyclosporine, and cyclophosphamide, whereas was terminated in mice treated with mycophenolate mofetil. After the withdrawal, HBV replication was at low or high levels in the dexamethasone-treated mice or in both cyclosporine- and cyclophosphamide-treated mice. The early withdrawal of cyclosporine allowed the recovery of suppressed T cell responses and led to subsequent HBV clearance, while the adoptive immune transfer to the mice with HBV persistence led to HBV suppression. Taken together, long-term HBV persistence under immunosuppression depends on the immunosuppressive drugs used and on the treatment duration and is mediated by the suppressed intrahepatic CD8 T cell response. These data may be helpful for individualized immunosuppressive therapy in patients with high risk of HBV reactivation and recurrence, and the mouse system is suitable for studying HBV reactivation and recurrence under immunosuppression.</p></div