Details of anesthetic technique, and rescue analgesics and anti-emetics in the included trials.

<p>IV, intravenous; IM, intramuscular; ^ano difference.</p><p>Details of anesthetic technique, and rescue analgesics and anti-emetics in the included trials.</p

Figure S3 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies

 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies Suppl fig</p

Need for rescue analgesics grouped by concomitant anti-emetics.

<p>Six studies described the need for rescue analgesics in thyroidectomy patients treated with dexamethasone versus placebo with or without concomitant anti-emetics (RR 0.65, 95% CI 0.50–0.83, <i>P</i> = 0.0008). There was no evidence of significant heterogeneity between RCTs (<i>P</i> = 0.25, <i>I</i>² = 25%).</p

Figure S1 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies

 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies Suppl fig</p

Flow chart for selecting the trials.

<p>On the basis of the search strategy, 195 articles were identified by the initial search, and 17 required further assessment. Finally, 13 articles were included in this review.</p

Figure S4 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies

 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies Suppl data</p

PRISMA_2020_checklist Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies

 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies PRISMA checklist</p

VAS post-operative pain score grouped by dexamethasone dose.

<p>Six studies described post-operative pain scores in thyroidectomy patients treated with dexamethasone versus placebo with or without concomitant anti-emetics (WMD –1.17, 95% CI –1.91 to –0.44, <i>P</i> = 0.002). There was evidence of significant heterogeneity between RCTs (<i>P</i><0.00001, <i>I²</i> = 94%).</p

Incidence of PONV grouped by concomitant anti-emetics.

<p>Eleven studies described the incidence of PONV in thyroidectomy patients treated with dexamethasone versus placebo with or without concomitant anti-emetics (RR 0.52, 95% CI 0.43 to 0.63, <i>P</i><0.00001). There was evidence of significant heterogeneity between studies (<i>P</i> = 0.003, <i>I²</i> = 56%).</p

Figure S2 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies

 Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies Suppl figure</p