<b>Zhengwang L</b><b>iu</b><b> PLPs-MSNs-</b><b>AsIV</b>

The goal of this study was to investigate the mechanism of PLPs-MSNs-AsIV on MIRI. In H/ R-induced H9c2 cells, we found increased cell damage, increased autophagy, and down-regulated phosphorylation of PI3K,AKT, and mTOR. After the addition of AsIV and PLPs-MSNs-AsIV, we observed an increase in the expression of P62 and a decrease in the expression of Beclin1 and LC3, implying a decrease in the level of autophagy, while PI3K/AKT/mTOR was activated and the cell damage was reduced. These findings propose that PLPs-MSNs-AsIV might regulate MIRI through modulation of autophagy via the PI3K/AKT/mTOR pathway, and that PLPs-MSNs-AsIV is superior to AsIV. Finally, rescue experiments further demonstrated that PLPs-MSNs-AsIV controlled autophagy via the PI3K/AKT/mTOR pathwayto protect cardiomyocytes. Our results reveal that PLPs-MSNs-AsIV protects myocyte by inhibiting autophagy through the PI3K/AKT/mTOR pathway and present a novel therapeutic strategy for MIRI.</p

Direct Imaging Au Nanoparticle Migration Inside Mesoporous Silica Channels

Supported metal nanoparticle (NP) catalysts have been widely used in many industry processes and catalytic reactions. Catalyst deactivation is mainly caused by the sintering of supported metal NPs. Hence, understanding the metal NPs’ sintering behaviors has great significance in preventing catalyst deactivation. Here we report the metal particle migration inside/between mesochannels by scanning transmission electron microscopy and electron energy loss spectroscopy via an in situ TEM heating technique. A sintering process is proposed that particle migration predominates, driven by the difference of gravitational potential from the height of the uneven internal surface of the mesopores; when the distance of the gold nanoparticles with a size of about 3 and 5 nm becomes short after migration, the coalescence process is completed, which is driven by an “octopus-claw-like” expansion of a conduction electron cloud outside the Au NPs. The supports containing an abundance of micropores help to suppress particle migration and coalescence. Our findings provide the understanding toward the rational design of supported industrial catalysts and other nanocomposites with enhanced activity and stability for applications such as batteries, catalysis, drug delivery, gas sensors, and solar cells

Double-Shelled Yolk–Shell Microspheres with Fe₃O₄ Cores and SnO₂ Double Shells as High-Performance Microwave Absorbers

Double-shelled yolk–shell microspheres with Fe₃O₄ cores and SnO₂ double shells have been successfully synthesized by combining the versatile sol–gel process and hydrothermal shell-by-shell deposition method. The as-synthesized double-shelled Fe₃O₄@SnO₂ yolk–shell microspheres have uniform size, unique morphology, well-defined shells, favorable magnetization, large specific surface area, and high porosity and exhibit significantly enhanced microwave absorption properties in terms of both the maximum reflection loss value and the absorption bandwidth. The excellent microwave absorption properties of these microspheres may be attributed to the unique double-shelled yolk–shell structure and synergistic effect between the magnetic Fe₃O₄ cores and dielectric SnO₂ shells

Synthesis and Microwave Absorption Properties of Yolk–Shell Microspheres with Magnetic Iron Oxide Cores and Hierarchical Copper Silicate Shells

Yolk–shell microspheres with magnetic Fe₃O₄ cores and hierarchical copper silicate shells have been successfully synthesized by combining the versatile sol–gel process and hydrothermal reaction. Various yolk–shell microspheres with different core size and shell thickness can be readily synthesized by varying the experimental conditions. Compared to pure Fe₃O₄, the as-synthesized yolk–shell microspheres exhibit significantly enhanced microwave absorption properties in terms of both the maximum reflection loss value and the absorption bandwidth. The maximum reflection loss value of these yolk–shell microspheres can reach −23.5 dB at 7 GHz with a thickness of 2 mm, and the absorption bandwidths with reflection loss lower than −10 dB are up to 10.4 GHz. Owing to the large specific surface area, high porosity, and synergistic effect of both the magnetic Fe₃O₄ cores and hierarchical copper silicate shells, these unique yolk–shell microspheres may have the potential as high-efficient absorbers for microwave absorption applications

High-Density Anisotropy Magnetism Enhanced Microwave Absorption Performance in Ti₃C₂T_<i>x</i> MXene@Ni Microspheres

Two-dimensional materials, especially the newly emerging MXene, have attracted numerous interests in the fields of energy conversion/storage and electromagnetic shielding/absorption. However, the inherently inevitable aggregation and absence of magnetic loss of MXene considerably limit its electromagnetic absorption application. The introduction of magnetic component and favorable structural engineering are the alternatives to improve the microwave absorption (MA) performance. Herein, we report a spheroidization strategy to assemble double-shell MXene@Ni microspheres, where the commonly lamellar MXene are reshaped into three-dimensional microspheres that provide the substrate for oriented growth of Ni nanospikes. Whereas this structural feature offers massive accessible active surfaces that effectively promote the dielectric loss ability, the introduction of magnetic Ni nanospikes enables the additional magnetic loss capacity. Benefiting from these merits, the synthesized 3D MXene@Ni microspheres exhibit superior MA performance with the minimum reflection loss value of −59.6 dB at an ultrathin thickness (∼1.5 mm) and effective absorption bandwidth of 4.48 GHz. Moreover, the electron holography results reveal that the high-density anisotropy magnetism plays an important role in the improvement of MA performance, which provides an insight for the design of MXene-based materials as high-efficient microwave absorbers

Additional file 1 of A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy

Additional file 1. Additional tables and figures

Mesoporous TiO₂ Mesocrystals: Remarkable Defects-Induced Crystallite-Interface Reactivity and Their in Situ Conversion to Single Crystals

Oriented self-assembly between inorganic nanocrystals and surfactants is emerging as a route for obtaining new mesocrystalline semiconductors. However, the actual synthesis of mesoporous semiconductor mesocrystals with abundant surface sites is extremely difficult, and the corresponding new physical and chemical properties arising from such an intrinsic porous mesocrystalline nature, which is of fundamental importance for designing high-efficiency nanostructured devices, have been rarely explored and poorly understood. Herein, we report a simple evaporation-driven oriented assembly method to grow unprecedented olive-shaped mesoporous TiO₂ mesocrystals (FDU-19) self-organized by ultrathin flake-like anatase nanocrystals (∼8 nm in thickness). The mesoporous mesocrystals FDU-19 exhibit an ultrahigh surface area (∼189 m²/g), large internal pore volume (0.56 cm³/g), and abundant defects (oxygen vacancies or unsaturated Ti³⁺ sites), inducing remarkable crystallite-interface reactivity. It is found that the mesocrystals FDU-19 can be easily fused in situ into mesoporous anatase single crystals (SC-FDU-19) by annealing in air. More significantly, by annealing in a vacuum (∼4.0 × 10^–5 Pa), the mesocrystals experience an abrupt three-dimensional to two-dimensional structural transformation to form ultrathin anatase single-crystal nanosheets (NS-FDU-19, ∼8 nm in thickness) dominated by nearly 90% exposed reactive (001) facets. The balance between attraction and electrostatic repulsion is proposed to determine the resulting geometry and dimensionality. Dye-sensitized solar cells based on FDU-19 and SC-FDU-19 samples show ultrahigh photoconversion efficiencies of up to 11.6% and 11.3%, respectively, which are largely attributed to their intrinsic single-crystal nature as well as high porosity. This work gives new understanding of physical and chemical properties of mesoporous semiconductor mesocrystals and opens up a new pathway for designing various single-crystal semiconductors with desired mesostructures for applications in catalysis, sensors, drug delivery, optical devices, etc

Mesoporous TiO₂ Mesocrystals: Remarkable Defects-Induced Crystallite-Interface Reactivity and Their in Situ Conversion to Single Crystals

Oriented self-assembly between inorganic nanocrystals and surfactants is emerging as a route for obtaining new mesocrystalline semiconductors. However, the actual synthesis of mesoporous semiconductor mesocrystals with abundant surface sites is extremely difficult, and the corresponding new physical and chemical properties arising from such an intrinsic porous mesocrystalline nature, which is of fundamental importance for designing high-efficiency nanostructured devices, have been rarely explored and poorly understood. Herein, we report a simple evaporation-driven oriented assembly method to grow unprecedented olive-shaped mesoporous TiO₂ mesocrystals (FDU-19) self-organized by ultrathin flake-like anatase nanocrystals (∼8 nm in thickness). The mesoporous mesocrystals FDU-19 exhibit an ultrahigh surface area (∼189 m²/g), large internal pore volume (0.56 cm³/g), and abundant defects (oxygen vacancies or unsaturated Ti³⁺ sites), inducing remarkable crystallite-interface reactivity. It is found that the mesocrystals FDU-19 can be easily fused in situ into mesoporous anatase single crystals (SC-FDU-19) by annealing in air. More significantly, by annealing in a vacuum (∼4.0 × 10^–5 Pa), the mesocrystals experience an abrupt three-dimensional to two-dimensional structural transformation to form ultrathin anatase single-crystal nanosheets (NS-FDU-19, ∼8 nm in thickness) dominated by nearly 90% exposed reactive (001) facets. The balance between attraction and electrostatic repulsion is proposed to determine the resulting geometry and dimensionality. Dye-sensitized solar cells based on FDU-19 and SC-FDU-19 samples show ultrahigh photoconversion efficiencies of up to 11.6% and 11.3%, respectively, which are largely attributed to their intrinsic single-crystal nature as well as high porosity. This work gives new understanding of physical and chemical properties of mesoporous semiconductor mesocrystals and opens up a new pathway for designing various single-crystal semiconductors with desired mesostructures for applications in catalysis, sensors, drug delivery, optical devices, etc