Data_Sheet_1_Anticoagulant for treatment and prophylaxis of venous thromboembolism patients with renal dysfunction: A systematic review and network meta-analysis.docx

ObjectiveThe aim of this study was to compare the efficacy and safety for particular regimen and dosage in venous thromboembolism (VTE) patients with renal insufficiency.MethodsEnglish language searches of PubMed, Embase, and Web of Science (inception to May 2021). RCTs evaluating anticoagulants for VTE treatment at acute phase, extension phase, and VTE prophylaxis in patients with renal insufficiency and reporting efficacy (death, recurrence, or occurrence of VTE) and safety (bleeding) outcomes were selected. The methodological quality of each study included was assessed at the outcome level using the risk-of-bias assessment tool developed by the Cochrane Bias Methods Group.ResultsTwenty-one trials that involved 76,574 participants and 8,972 (11.7%) patients with renal insufficiency were enrolled, including 10 trials on VTE treatment in acute phase (3–12 months), four trials on VTE treatment in extension phase (6–36 months), and seven trials for VTE prophylaxis. For acute VTE treatment, compared with dabigatran etexilate, apixaban (RR 5.90, 95%CI 1.00–34.60) and rivaroxaban (RR 6.18, 95%CI 1.17–32.75) were significantly associated with increased risk of death or recurrence. For extension treatment of VTE, aspirin had the highest probability of the most effective and safest treatment, followed by apixaban. For VTE prophylaxis, compared with enoxaparin, desirudin was associated with lower risk of VTE occurrence (RR 0.56, 95% CI 0.34–0.91), but had higher risk of bleeding than dabigatran etexilate.ConclusionThe network meta-analysis informs the optimal choice of anticoagulants and their particular dosage for treatment and prophylaxis of VTE patients comorbid renal insufficiency.Systematic review registrationwww.crd.york.ac.uk/prospero/, identifier: CRD42021254086.</p

Correlations between RT3DE-derived and CMR-derived RV parameters.

<p>Correlations between RT3DE-derived and CMR-derived RV parameters.</p

Correlation between RT3DE-derived and CMR-derived RV parameters.

<p>(A) Correlation of RVEDV values obtained via RT3DE and CMR. (B) Correlation between RVESV values measured via RT3DE and CMR. (C) Correlation between RVEF values measured by RT3DE and CMR.</p

Patients characteristics (n = 23).

<p>Patients characteristics (n = 23).</p

Bland-Altman analysis of parameters measured by RT3DE and CMR.

<p>(A) Bland-Altman analyses of RT3DE and CMR measurements of RVEDV. (B) Bland-Altman analysis of RT3DE and CMR measurements of RVESV. (C) Bland-Altman analysis of RT3DE and CMR measurements of RVEF.</p

Echocardiography and CMR data.

<p>RVMPI: right ventricle myocardial performance index.</p><p>Echocardiography and CMR data.</p

The regional distribution of case fatality rates for PE in China.

<p>The regional distribution of case fatality rates for PE in China.</p

The discrepancy between the North and the South in incidence and case fatality rates for PE in China from 1997 to 2008.

<p>The discrepancy between the North and the South in incidence and case fatality rates for PE in China from 1997 to 2008.</p

Incidence and case fatality rates for PE in hospitalized adults from 1997 to 2008.

<p>Incidence and case fatality rates for PE in hospitalized adults from 1997 to 2008.</p

The incidence of PE in hospitalized patients by age and gender in China (%) during 12 years (from 1997 to 2008).

<p>The incidence of PE in hospitalized patients by age and gender in China (%) during 12 years (from 1997 to 2008).</p