Additional file 1 of Psychometric evaluation of the Chinese version of advance care planning self-efficacy scale among clinical nurses

Additional file 1

Data_Sheet_1_Knowledge structure and future research trends of body–mind exercise for mild cognitive impairment: a bibliometric analysis.pdf

BackgroundMild cognitive impairment (MCI) is a common neurodegenerative disorder that poses a risk of progression to dementia. There is growing research interest in body–mind exercise (BME) for patients with MCI. While we have observed a rapid growth in interest in BME for MCI over the past 10 years, no bibliometric analysis has investigated the knowledge structure and research trends in this field. Consequently, the objective of this research is to conduct a bibliometric analysis of global publications of BME for MCI from 2013 to 2022.MethodsA total of 242 publications in the field of BME for MCI were retrieved from the Web of Science Core Collection. Bibliometric analysis, including performance analysis, science mapping, and visualization, was performed using CiteSpace, VOSviewer, and Microsoft Excel.ResultsPublications and citations in the field of BME for MCI have shown a rapidly increasing trend over the last decade. Geriatrics & Gerontology, and Neurosciences were the most frequently involved research categories. China (78 documents) and the USA (75 documents) contributed to the largest number of publications and had the strongest international collaborative networks. Fujian University of Traditional Chinese Medicine contributed to the largest number of publications (12 documents), and Chen, L of this institution was the most prolific author (12 documents). Frontiers in Aging Neuroscience (16 documents), and JOURNAL OF ALZHEIMER’S DISEASE (12 documents) were the most prolific journals. Tai Chi and Baduanjin, as specific types of BME, were the hotspots of research in this field, while evidence synthesis and guidelines might be future research trends.ConclusionIn the last decade, there has been a rapid growth in scientific activities in the field of BME for MCI. The results of this study provide researchers and other stakeholders with knowledge structure, hotspots, and future research trends in this field.</p

Stereoselective Synthesis of Oxabicyclo[2.2.1]heptenes via a Tandem Dirhodium(II)-Catalyzed Triazole Denitrogenation and [3 + 2] Cycloaddition

A novel synthetic strategy for the diastereoselective synthesis of structurally diverse oxabicyclo[2.2.1]­heptenes has been developed, featuring a tandem reaction combining a Rh-catalyzed triazole denitrogenation and a novel type of [3 + 2] cycloaddition reaction. This tandem reaction was thought to proceed via a five-membered oxonium ylide intermediate, which was formed by the intramolecular nucleophilic attack of the carbonyl group on the α-imino metallocarbene followed by an inter- or intramolecular [3 + 2] dipolar cycloaddition with a range of alkynes and alkenes

Stereoselective Synthesis of Oxabicyclo[2.2.1]heptenes via a Tandem Dirhodium(II)-Catalyzed Triazole Denitrogenation and [3 + 2] Cycloaddition

A novel synthetic strategy for the diastereoselective synthesis of structurally diverse oxabicyclo[2.2.1]­heptenes has been developed, featuring a tandem reaction combining a Rh-catalyzed triazole denitrogenation and a novel type of [3 + 2] cycloaddition reaction. This tandem reaction was thought to proceed via a five-membered oxonium ylide intermediate, which was formed by the intramolecular nucleophilic attack of the carbonyl group on the α-imino metallocarbene followed by an inter- or intramolecular [3 + 2] dipolar cycloaddition with a range of alkynes and alkenes

Best-3 ameliorated TNFα-induced inflammatory response in endothelial cells.

<p>(<b>A, B</b>) HUVECs were transfected with Lacz or Ad-Best-3 for 48 h prior to TNFα treatment for 24 h. ICAM-1 (A) and VCAM-1 (B) were examined by western blot, respectively. (<b>C</b>) after treatment mentioned in (A, B), adhesion of VibrantDiO-labeled THP-1 to HUVECs were analyzed. (<b>D, E</b>) HUVECs were transfected with negative siRNA (Neg. RNA) or Best-3 siRNA for 48 h prior to TNFα incubation. ICAM-1 (D) and VCAM-1 (E) were detected by western blot, respectively. (<b>F</b>) after treatment mentioned in (D, E), adhesion of THP-1 to HUVECs was analyzed. (<b>G, H</b>) western blot detection of ICAM-1 (G) and VCAM-1 (H) expressions in MAECs isolated form mice after treatment mentioned in method section. (<b>I</b>) adhesion of THP-1 to MAECs was analyzed. All data are presented as mean ± SEM. **P<0.01 vs. control, ^#P<0.05, ^##P<0.01 vs. TNFα alone, n = 6.</p

The mean and standard deviation of the familiarity degree and association degree rating in Experiment 3.

<p>Note: M = mean; SD = standard deviation.</p

Reduced inflammatory response in Ad-Best-3-infected mice.

<p>C57BL/6 mice were infected with Ad-Best-3 (10⁹ pfu/mouse) or Lacz (10⁹ pfu/mouse) for 1 week in the presence of TNFα (30 µg/kg) for another 3 days. (<b>A. B</b>) the expression of ICAM-1 and VCAM-1 in the aorta was analyzed by quantitative PCR (A, upper panel) and western blot (B, middle panel), respectively. **P<0.01 vs. control, ^##P<0.01 vs. TNFα alone, n = 7. (<b>C, D</b>) immunofluorescent staining of Best-3 (green) and ICAM-1 (red) and Hoechst (blue) (C), or Best-3 (green) and VCAM-1 (red) and Hoechst (blue) (D) in thoracic aorta of mice, respectively. Scale bars, 40 µm. n = 4–6.</p

Stereoselective Synthesis of Oxabicyclo[2.2.1]heptenes via a Tandem Dirhodium(II)-Catalyzed Triazole Denitrogenation and [3 + 2] Cycloaddition

A novel synthetic strategy for the diastereoselective synthesis of structurally diverse oxabicyclo[2.2.1]­heptenes has been developed, featuring a tandem reaction combining a Rh-catalyzed triazole denitrogenation and a novel type of [3 + 2] cycloaddition reaction. This tandem reaction was thought to proceed via a five-membered oxonium ylide intermediate, which was formed by the intramolecular nucleophilic attack of the carbonyl group on the α-imino metallocarbene followed by an inter- or intramolecular [3 + 2] dipolar cycloaddition with a range of alkynes and alkenes

Bestrophin 3 Ameliorates TNFα-Induced Inflammation by Inhibiting NF-κB Activation in Endothelial Cells

<div><p>Increasing evidences have suggested vascular endothelial inflammatory processes are the initiator of atherosclerosis. Bestrophin 3 (Best-3) is involved in the regulation of cell proliferation, apoptosis and differentiation of a variety of physiological functions, but its function in cardiovascular system remains unclear. In this study, we investigated the effect of Best-3 on endothelial inflammation. We first demonstrated that Best-3 is expressed in endothelial cells and decreased after tumor necrosis factor-α (TNFα) challenge. Overexpression of Best-3 significantly attenuated TNFα-induced expression of adhesion molecules and chemokines, and subsequently inhibited the adhesion of monocytes to human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of Best-3 with siRNA resulted in an enhancement on TNFα-induced expression of adhesion molecules and chemokines and adhesion of monocytes to HUVECs. Furthermore, overexpression of Best-3 with adenovirus dramatically ameliorated inflammatory response in TNFα-injected mice. Mechanistically, we found up-regulation of Best-3 inhibited TNFα-induced IKKβ and IκBα phosphorylation, IκBα degradation and NF-κB translocation. Our results demonstrated that Best-3 is an endogenous inhibitor of NF-κB signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases.</p></div

The mean and standard deviation of the estimated weight and the number of strokes for the target words selected for Experiment 2.

<p>Note: M = mean; SD = standard deviation; kg = kilogram.</p