A General Synthesis of Ynones from Aldehydes via Oxidative C–C bond Cleavage under Aerobic Conditions

We describe a direct synthesis of various ynones from readily available aldehydes and hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the desired ynone through an <i>in situ</i> C–C bond oxidative cleavage using molecular oxygen

Highly <i>trans-</i>Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-Catalyzed Triple Cascade Catalysis

A triple cascade was developed using a simple copper catalyst to <i>trans</i>-selectively access bicyclic isoxazolidines in a one-pot synthesis. This strategy features the in situ generation of nitrones and subsequent trapping by [3 + 2] cycloaddition. In this method, copper serves three catalytic functions: as a Lewis acid for the ene reaction, as an organometallic for aerobic oxidation, and as a Lewis acid for an <i>endo</i>-selective [3 + 2] cycloaddition. The successful merging of aerobic oxidation and Lewis acid catalysis demonstrated efficient cascade synergy

Highly <i>trans-</i>Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-Catalyzed Triple Cascade Catalysis

A triple cascade was developed using a simple copper catalyst to <i>trans</i>-selectively access bicyclic isoxazolidines in a one-pot synthesis. This strategy features the in situ generation of nitrones and subsequent trapping by [3 + 2] cycloaddition. In this method, copper serves three catalytic functions: as a Lewis acid for the ene reaction, as an organometallic for aerobic oxidation, and as a Lewis acid for an <i>endo</i>-selective [3 + 2] cycloaddition. The successful merging of aerobic oxidation and Lewis acid catalysis demonstrated efficient cascade synergy

Highly <i>trans-</i>Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-Catalyzed Triple Cascade Catalysis

A triple cascade was developed using a simple copper catalyst to <i>trans</i>-selectively access bicyclic isoxazolidines in a one-pot synthesis. This strategy features the in situ generation of nitrones and subsequent trapping by [3 + 2] cycloaddition. In this method, copper serves three catalytic functions: as a Lewis acid for the ene reaction, as an organometallic for aerobic oxidation, and as a Lewis acid for an <i>endo</i>-selective [3 + 2] cycloaddition. The successful merging of aerobic oxidation and Lewis acid catalysis demonstrated efficient cascade synergy

Additional file 1 of Comparison between immunotherapy efficacy in early non-small cell lung cancer and advanced non-small cell lung cancer: a systematic review

Additional file 1: Fig. S1. A selection flowchart for the searched articles. Fig. S2. Forest plots presenting pooled ORR risk ratio analysis in early-stage lung cancer for the cohort of immunotherapy combined with chemotherapy. Fig. S3. Forest plots presenting pooled ORR risk ratio analysis in advanced lung cancer for the cohort of immunotherapy combined with chemotherapy. Fig. S4. Forest plots presenting pooled DCR risk ratio analysis in advanced lung cancer for the cohort of immunotherapy combined with chemotherapy

Spatial-temporal dynamics of transboundary forest disturbance-recovery and its influencing factors in the central Himalayas

Transboundary forests in the Himalayas are one of the world’s biodiversity hotspots, but exploring the patterns and influencing factors related to forest disturbance-recovery is still limited. In this study, we used a random forests model, a LandTrendr temporal segmentation algorithm and geographical detector to investigate the spatial and temporal evolution characteristics of forest disturbance and recovery and their influencing factors in the central Himalayas from 1995 to 2018. The results showed that forest disturbance was dominant (∼2.94 × 104 km2) and greater than recovery (∼0.56 × 104 km2). Both disturbance and recovery showed a significant decreasing trend (p < 0.01); disturbance occurred mainly at low elevations and the Gandaki basin, while recovery was in eastern Nepal. Disturbance rates were highest in Nepal (1.14%) and recovery rates in China (0.29%). The main influencing factors on forest dynamics were elevation, temperature and population. The interaction of all factors was synergistically enhanced.</p