7 research outputs found
Method for Accessing Nitrogen-Containing, <i>B</i>‑Heteroaryl-Substituted 2,1-Borazaronaphthalenes
The
azaborine motif provides a mimic of aromatic systems through
replacement of a CC bond with a B–N bond. In particular,
2,1-borazaronaphthalenes, accessible through robust methods of synthesis
and subsequent functionalization, afford an ideal platform to use
for a variety of applications. However, the scope of substructures
for this archetype has been limited by the lack of nitrogen-containing
heteroaryls that can be incorporated within them. In this study, modified
reaction conditions were developed to provide access to a wider range
of substructures
Silver-Promoted Oxidative Cyclization of 1,6-Enynes: Highly Regioselective Synthesis of Phosphorated Fluorene Derivatives
A silver-promoted
oxidative cyclization of 1,6-enynes with disubstituted
phosphine oxides is developed for the synthesis of fluorene derivatives.
The reaction proceeds with high regioselectivity by constructing one
C–P bond and two C–C bonds in one step. Moreover, reduction
of the pentavalent phosphine enlarges the application scope of the
product
Silver-Promoted Oxidative Cyclization of 1,6-Enynes: Highly Regioselective Synthesis of Phosphorated Fluorene Derivatives
A silver-promoted
oxidative cyclization of 1,6-enynes with disubstituted
phosphine oxides is developed for the synthesis of fluorene derivatives.
The reaction proceeds with high regioselectivity by constructing one
C–P bond and two C–C bonds in one step. Moreover, reduction
of the pentavalent phosphine enlarges the application scope of the
product
Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes
A novel and highly
practical reaction for the copper-catalyzed
intermolecular cyanotrifluoromethylation of alkenes is presented here.
This methodology provides a general and straightforward way to synthesize
a variety of useful CF<sub>3</sub>-containing nitriles, which can
be used for further preparation of pharmaceutically and agrochemically
important compounds in synthetic organic chemistry
Copper-Catalyzed Three-Component CyanoÂtrifluoroÂmethylaÂtion/AzidoÂtrifluoroÂmethylaÂtion and CarboÂcycliÂzation of 1,6-Enynes
A novel three-component
strategy for the cyanoÂtrifluoroÂmethylaÂtion/azidoÂtrifluoroÂmethylaÂtion
and carbocyclization of 1,6-enynes is developed. The reaction proceeds
smoothly under a moderate temperature by using a copper catalyst,
which provides a rapid and concise access to addition–carbocyclization
products. Furthermore, the products obtained can be useful building
blocks in discoveries of lead compounds and other biologically active
CF<sub>3</sub>-containing heterocycles
Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes
A novel and highly
practical reaction for the copper-catalyzed
intermolecular cyanotrifluoromethylation of alkenes is presented here.
This methodology provides a general and straightforward way to synthesize
a variety of useful CF<sub>3</sub>-containing nitriles, which can
be used for further preparation of pharmaceutically and agrochemically
important compounds in synthetic organic chemistry
Iodine-Promoted Radical Cyclization in Water: A Selective Reaction of 1,6-Enynes with Sulfonyl Hydrazides
An iodine-promoted one-pot radical
cyclization reaction of 1,6-enynes
with sulfonyl hydrazides to provide five-membered and hexatomic ring
sulfonylated products under the same conditions is established. This
reaction proceeded smoothly in water and gave the corresponding products
by using I<sub>2</sub>/TBHP instead of expensive and toxic catalysts
with C–S and C–I bond formed in one step. This method
also allowed easy access to significant functional sulfones for potential
applications in medicinal and organic chemistry