Clinical application of platelet-rich fibrin as the sole grafting material in periodontal intrabony defects

AbstractBackground/purposePlatelet-rich fibrin (PRF) obtained by Choukroun’s technique is a healing biomaterial that concentrates in a single autologous fibrin membrane, mostly of platelets and cytokines from blood harvest, and without any artificial biochemical modification. However, no data are presently available concerning the use of PRF for the treatment of periodontal intrabony defects. This report was to present the clinical and radiographic changes of a patient with periodontal intrabony defects treated with PRF.Material and methodsThe left mandibular first molar (#36) and left maxillary second molar (#27) with intrabony defects were filled with PRF as the sole grafting material in a 38-year-old female patient. The primary outcomes evaluated in this study included changes in probing depth, attachment level, and radiographic bone density between baseline and 6 months postoperatively.ResultsThe results showed that the application of PRF as the sole grafting material in intrabony defects exhibited pocket reduction and gain in clinical attachment after 3 months and 6 months. Using National institute of health program, the 6 months postoperative radiographic density of images for #27 and #36 showed an increase of 1.6 and 1.3 fold compared with each preoperative radiography, respectively.ConclusionsFrom a clinical and radiologic point of view at 6 months after surgery, the use of PRF as the sole grafting material seems to be an effective modality of regenerative treatment for periodontal intrabony defects

Management of radicular cysts using platelet-rich fibrin and bioactive glass: A report of two cases

Platelet-rich fibrin (PRF) created by Choukroun’s protocol concentrates most platelets and leukocytes from a blood harvest into a single autologous fibrin biomaterial. However, no current data is available concerning the use of PRF for the treatment of periapical lesions. Two cases of radicular cysts were reported using an interdisciplinary approach, including regular endodontic therapy followed by surgical management with PRF and bioactive glass. Two cases of radicular cysts presented as an incidental radiographic finding, appearing as an apical radiolucency with well-circumscribed sclerotic borders. After regular endodontic retreatment, cystic lining/granulation tissues were enucleated and the periradicular bony defect was grafted using PRF and bioactive glass. Then, PRF was applied to serve as a membrane over the grafted defects. Recall periapical radiographs of Case 1 and cone beam computer tomography of Case 2 showed satisfactory healing of the periapical pathosis. In Case 2, the bony defect appeared completely healed at 4 months surgical reentry and the new bone was clinically very dense and mature. The results of these case reports show that the combination of PRF and bioactive glass is an effective modality of regenerative treatment for radicular cysts