Additional file 1 of N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk

Supplementary Material 1

MOESM1 of Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Additional file 1. Information on 721 identified compounds in EXD

MOESM2 of Blood and urinary metabolomic evidence validating traditional Chinese medicine diagnostic classification of major depressive disorder

Additional file 2. Minimum Standards of Reporting Checklist

sj-docx-1-aim-10.1177_09645284221077106 – Supplemental material for Acupuncture for insomnia after ischemic stroke: an assessor-participant blinded, randomized controlled trial

Supplemental material, sj-docx-1-aim-10.1177_09645284221077106 for Acupuncture for insomnia after ischemic stroke: an assessor-participant blinded, randomized controlled trial by Yan Cao, Yin-Jie Yan, Jian-Yang Xu, Abulikemu Liwayiding, Yi-Ping Liu, Xuan Yin, Li-Xing Lao, Zhang-Jin Zhang and Shi-Fen Xu in Acupuncture in Medicine</p

sj-pdf-1-aim-10.1177_09645284221077106 – Supplemental material for Acupuncture for insomnia after ischemic stroke: an assessor-participant blinded, randomized controlled trial

Supplemental material, sj-pdf-1-aim-10.1177_09645284221077106 for Acupuncture for insomnia after ischemic stroke: an assessor-participant blinded, randomized controlled trial by Yan Cao, Yin-Jie Yan, Jian-Yang Xu, Abulikemu Liwayiding, Yi-Ping Liu, Xuan Yin, Li-Xing Lao, Zhang-Jin Zhang and Shi-Fen Xu in Acupuncture in Medicine</p

Image_1_Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway.JPEG

Electroacupuncture (EA) pretreatment is a clinically useful therapy for several brain disorders. However, whether and via which exact molecular mechanisms it ameliorates post-traumatic stress disorder (PTSD) remains unclear. In the present study, rats received EA stimulation for seven consecutive days before exposure to enhanced single prolonged stress (ESPS). Anxiety-like and fear learning behaviors; hippocampal neurogenesis; the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (keap1), and heme oxygenase 1 (HO-1); and the activity of AMP-activated kinase (AMPK) were evaluated at 14 days after ESPS. EA pretreatment improved hippocampal neurogenesis and ameliorated anxiety-like behaviors in ESPS-treated rats. EA pretreatment also increased the expression of Nrf2 and HO-1 and the activity of AMPK. Furthermore, Nrf2 knockdown by a short hairpin RNA affected anxiety-like behaviors and expression of neuroprotective markers (BDNF, DCX) in a manner similar to ESPS alone and dampened the neuroprotective effects of EA pretreatment. In contrast, Keap1 knockdown increased the expression of HO-1, improved hippocampal neurogenesis, and alleviated PTSD-like behaviors. Altogether, our results suggest that EA pretreatment ameliorates ESPS-induced anxiety-like behaviors and prevents hippocampal neurogenesis disruption in a rat model of PTSD possibly through regulation of the keap1/Nrf2 antioxidant defense pathway.</p

MOESM2 of Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study

Additional file 2: Table S1. A statistical screening of connectomic variables between healthy subjects and traditional Chinese medicine diagnostic subtypes of major depressive disorders

Additional file 1 of Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial

Additional file 1: eTable S1A. Location and traditional Chinese medicine (TCM)-based therapeutic effects of the acupoints used in the trial. eTable S1B. Recommendation of additional acupoints based on common comorbid symptoms. eTable S1C. Detailed treatment procedures of active and sham acupuncture regimen. eTable S2A. Cessation rate, dose and weekly frequency of use of sleeping medications. eTable S2B. Characteristics of participants use sedatives, hypnotics, anxiolytics. eTable S3. Tipping-point sensitivity analysis for shift ISI score. eTable S4. Expectancy for treatment outcomes between groups. eTable S5. Adverse events related to treatment. eTable S6. Credibility toward treatment between the two groups. eTable S7A. Assessment of successiveness of blinding. eTable S7B. Results of blinding assessment

MOESM1 of Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study

Additional file 1. Minimum Standards of Reporting Checklist

Bivariate and multivariate associations of clinical outcomes with demographic and clinical variables in schizophrenic patients in Chinese medicine and antipsychotic concomitant treatment.^a

<p>a. CM, Chinese medicine; IM, improved; WS, worse. Data analyses were based on CM users (N = 671) who had clinical outcomes with improved (n = 410), worse (n = 48), and unchanged (n = 213) conditions. The unchanged condition served as reference. Chi-square test was used for bivariate analysis and multinomial logistic regression for multivariate analysis.</p><p>b. The definitions of household income and non-paranoid schizophrenia are the same as <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017239#pone-0017239-t001" target="_blank">Table 1</a>.</p