1,4-Ditosyl-1,4-diazepane

In the title compound, C19H24N2O4S2, the dihedral angle formed by the benzene rings is 82.88 (7)°, and the mol­ecular conformation is enforced by weak intra­molecular C—H⋯O contacts. Two C atoms of the 1,4-diazepane ring are disordered over two sets of sites with a refined occupancy ratio of 0.534 (13):0.466 (13). In the crystal, mol­ecules are linked by weak inter­molecular C—H⋯O inter­actions into chains parallel to the a axis

Resilient Delayed Impulsive Control for Consensus of Multiagent Networks Subject to Malicious Agents

Impulsive control is widely applied to achieve the consensus of multiagent networks (MANs). It is noticed that malicious agents may have adverse effects on the global behaviors, which, however, are not taken into account in the literature. In this study, a novel delayed impulsive control strategy based on sampled data is proposed to achieve the resilient consensus of MANs subject to malicious agents. It is worth pointing out that the proposed control strategy does not require any information on the number of malicious agents, which is usually required in the existing works on resilient consensus. Under appropriate control gains and sampling period, a necessary and sufficient graphic condition is derived to achieve the resilient consensus of the considered MAN. Finally, the effectiveness of the resilient delayed impulsive control is well demonstrated via simulation studies

Effect of Soaking Time on the Quality of Soymilk and Their Correlation Analysis

The effects of soybean soaking time (6, 8, 10, 12, 14, 16 h) on the physicochemical properties and sensory quality of soymilk were studied, which provided theoretical support for the selection of soybean soaking time. Soybean moisture content and distribution, soluble protein content, solid content, particle size, viscosity, stability and sensory score were used as indicators to analyze the influence of soaking time on the quality of soymilk and determine the optimal soaking time of soybean. The relationships between soaking time, soybean moisture composition and soymilk quality were analyzed by using the Pearson's correlation method. The results of low-field NMR showed that with the increase of soaking time, the signal values of T21, T22 and T23 increased, and the proportion of adsorbed water increased. The soybean moisture reached saturation after 12 h soaking. The results of the quality study showed that with the increase of soaking time, the protein transfer rate, the average particle size at volume and viscosity of soymilk had a trend of increasing first and then decreasing. The total solids content decreased significantly (P<0.05), and soymilk stability decreased first and then increased. The sensory comprehensive score first increased and then decreased, with the highest score of 1.0466 after 8 h soaking, followed by 10 h soaking. Based on the above results, 8 h was chosen as the best soaking time for soybeans to make soymilk. Despite the viscosity, the taste score and the brightness value were low after 8 h soaking, the soluble protein content was the highest, which was 0.905 g/100 g, and the protein transfer rate reached 16.61%. The total solids content was 3.185 g/100 g after 8 h soaking, which was second only to 6 h of soaking. Meanwhile, b value was the lowest, and the sensory comprehensive evaluation value was the highest after 8 h soaking. The correlation analysis results showed that the soaking time was significantly negatively correlated with the proportion of soybean bound water and free water, and significantly positively correlated with the proportion of adsorbed water (r=−0.9638, −0.8241, 0.9391). The quality index of soymilk was affected by the soaking time, which was significantly negatively correlated with the soluble protein, the total solids content and the L value, and significantly positively correlated with a value (r=−0.9122, −0.9726, −0.8238, 0.9385)

Stability of Excited Dressed States with Spin-Orbit Coupling

We study the decay behaviors of ultracold atoms in metastable states with spin-orbit coupling (SOC), and demonstrate that there are two SOC-induced decay mechanisms. One arises from the trapping potential and the other is due to interatomic collision. We present general schemes for calculating decay rates from these two mechanisms, and illustrate how the decay rates can be controlled by experimental parameters.We experimentally measure the decay rates over a broad parameter region, and the results agree well with theoretical calculations. This work provides an insight for both quantum simulation involving metastable dressed states and studies on few-body problems with SO coupling.Comment: 4.5 pages, 4 figures, the latest versio

Identification of potential key genes associated with severe pneumonia using mRNA-seq

This study aimed to identify the potential key genes associated with severe pneumonia using mRNA-seq. Nine peripheral blood samples from patients with severe pneumonia alone (SP group, n=3) and severe pneumonia accompanied with chronic obstructive pulmonary disease (COPD; CSP group, n=3), as well as volunteers without pneumonia (control group, n=3) underwent mRNA-seq. Based on the sequencing data, differentially expressed genes (DEGs) were identified by Limma package. Following the pathway enrichment analysis of DEGs, the genes that were differentially expressed in the SP and CSP groups were selected for pathway enrichment analysis and coexpression analysis. In addition, potential genes related to pneumonia were identified based on the information in the Comparative Toxicogenomics Database. In total, 645 and 528 DEGs were identified in the SP and CSP groups, respectively, compared with the normal controls. Among these DEGs, 88 upregulated genes and 80 downregulated genes were common between the two groups. The functions of the common DEGs were similar to those of the DEGs in the SP group. In the coexpression network, the commonly downregulated genes (including ND1, ND3, ND4L, and ND6) and the commonly upregulated genes (including TSPY6P and CDY10P) exhibited a higher degree. In addition, 131 DEGs (including ND1, ND3, ND6, MIR449A and TAS2R43) were predicted to be potential pneumonia-related genes. In conclusion, the present study demonstrated that the common DEGs may be associated with the progression of severe pneumonia

Interrelated Thermalization and Quantum Criticality in a Lattice Gauge Simulator

Gauge theory and thermalization are both foundations of physics and nowadays are both topics of essential importance for modern quantum science and technology. Simulating lattice gauge theories (LGTs) realized recently with ultracold atoms provides a unique opportunity for carrying out a correlated study of gauge theory and thermalization in the same setting. Theoretical studies have shown that an Ising quantum phase transition exists in this implemented LGT, and quantum thermalization can also signal this phase transition. Nevertheless, it remains an experimental challenge to accurately determine the critical point and controllably explore the thermalization dynamics in the quantum critical regime due to the lack of techniques for locally manipulating and detecting matter and gauge fields. Here, we report an experimental investigation of the quantum criticality in the LGT from both equilibrium and non-equilibrium thermalization perspectives by equipping the single-site addressing and atom-number-resolved detection into our LGT simulator. We accurately determine the quantum critical point agreed with the predicted value. We prepare a $|Z_{2}\rangle$ state deterministically and study its thermalization dynamics across the critical point, leading to the observation that this $|Z_{2}\rangle$ state thermalizes only in the critical regime. This result manifests the interplay between quantum many-body scars, quantum criticality, and symmetry breaking.Comment: 6+4 pages, 4+7 figure

Interval time between neoadjuvant chemotherapy and surgery in advanced gastric cancer doesn't affect outcome: A meta analysis

BackgroundThe efficacy of neoadjuvant chemotherapy for advanced gastric cancer is not yet firmly confirmed, but the exciting results demonstrated in several clinical studies have led neoadjuvant chemotherapy as the important treatment methods in guidelines. The 4–6 weeks interval time is currently the most commonly used in clinical treatment, but there are insufficient studies to support this time and the optimal interval has not yet been identified. The aim of this meta-analysis was to investigate the short-term life quality and long-term prognostic impact of the interval time between the end of neoadjuvant chemotherapy and surgery in patients with advanced gastric cancer.MethodsWe conducted a systematic literature search in PUBMED, Embase and Cochrane Liabrary for studies published or reported in English from January 2006 to May 2022. We summarised relevant studies for the time to surgery (TTS), included as retrospective studies and prospective studies. The primary study outcome was the rate of pathological complete response (pCR), and the secondary outcomes included R0 resection rate, incidence of serious postoperative complications, 3-year progression free survival time (PFS) rate and overall survival time (OS) rate. TTS were classified in three groups: 4–6 weeks, &lt;4 weeks and &gt;6 weeks. The ratio ratios (ORs) were calculated and forest plots and funnel plots were made to analysis by using fixed-effect and random-effect models in Review Manager 5.2.ResultsA total of five studies included 1,171 patients: 411 patients in shorter TTS group (&lt;4 weeks), 507 patients in medium TTS group (4–6 weeks) and 253 patients in longer TTS groups (&gt;6 weeks). And The results of our meta-analysis indicate that there are no significant difference between the three groups. The pCR, R0 resection rate, incidence of serious postoperative complications, 3-year PFS and OS were similar between three groups.ConclusionsAlthough there many studies exploring the suitable TTS in advanced gastric cancer, but we have not find the evidence to prove the TTS is the risk factor influencing the outcome.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD4202236900