PTSA-catalyzed one-pot synthesis of quinoxalines using DMSO as the oxidant

<p>An efficient p-toluene sulfonic acid–catalyzed, one-pot, two-step oxidative system for cyclization of o-diaminobenzene with 1,2-diaryl-2-hydroxyethanone to quinoxalines was described. A nontoxic, readily available oxidant, dimethylsulfoxide (DMSO), was applied in this process. A broad range of substrates was applied to this method, and target compounds were obtained with good yields.</p

One-Pot Synthesis of Pyrrolo­[1,2‑<i>a</i>]­quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction

A copper-catalyzed process for the synthesis of pyrrolo­[1,2-<i>a</i>]­quinoxalines from readily available α-amino acids and 1-(2-halophenyl)-1<i>H</i>-pyrroles is described. Different functional groups were well tolerated to give the corresponding products

Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo­[1,2-<i>a</i>]­quinoxalines, indolo­[1,2-<i>a</i>]­quinoxalines, 1<i>H</i>-pyrrolo­[3,2-<i>c</i>]­quinolines, and benzo­[4,5]­imidazo­[1,2-<i>c</i>]­quinazolines

Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4<i>H</i>)‑ones and Theoretical Study of the S–N Type Smiles Rearrangement Process

A series of 1,4-thiazepin-5­(4<i>H</i>)-one derivatives were synthesized via a transition metal-free one-pot Smiles rearrangement process at room temperature. Regioselective seven-membered heterocycles were constructed in good to excellent yields. To gain an in-depth understanding of the S–N type Smiles rearrangement mechanism, a theoretical study was also performed by quantum chemistry calculations

Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4<i>H</i>)‑ones and Theoretical Study of the S–N Type Smiles Rearrangement Process

A series of 1,4-thiazepin-5­(4<i>H</i>)-one derivatives were synthesized via a transition metal-free one-pot Smiles rearrangement process at room temperature. Regioselective seven-membered heterocycles were constructed in good to excellent yields. To gain an in-depth understanding of the S–N type Smiles rearrangement mechanism, a theoretical study was also performed by quantum chemistry calculations