A Novel Multi-Stage Ensemble Method for Online Junction Tempera-ture Estimation of SiC MOSFETs

SiC MOSFETs have been identified in numerous studies as having a significant risk of thermal failure. Consequently, temperature monitoring has become a crucial component of online condition monitoring for SiC MOSFETs. Currently, temperature-sensitive electrical parameters (TSEP) are commonly used for real-time monitoring of the junction temperature of single SiC chips. However, existing TSEPs face two primary challenges: low resolution, and difficulties on sensor acquiring posed by the high switching speed of SiC MOSFETs. Additionally, the high switching speed also induces electromagnetic interference (EMI), which adversely affects the accuracy of TSEP measurements. This study proposed a novel temperature prediction method, using the period between the rising edge of both the gate PWM and drain current. Experimental results show high sensitivity and strong interference immunity. The approach also features a simple, cost-effective circuit design and broad compatibility, allowing seamless integration with commercial gate drivers, thereby enhancing the intelligence of gate driver systems.</p

Supplemental Material - Study on preparation and performance of sulfonated polyaryl ether nitrile@Im-MOF-801(SPEN@Im-MOF-801)composite proton exchange membrane

Supplemental Material for Study on preparation and performance of sulfonated polyaryl ether nitrile@Im-MOF-801(SPEN@Im-MOF-801)composite proton exchange membrane by Yawei Meng, Jichang Sun, Zekun Li and Quanyi Liu in High Performance Polymers</p

Antilipogenesis Effect of Rutin-Loaded Liposomes Using a Microneedle Delivery System

Rutin, a flavonoid glycoside phytochemical compound, has a remarkable antiobesity effect. However, its therapeutic potential is hindered by its poor water solubility and low oral bioavailability. In this study, rutin was loaded into liposomes (LR) through the self-assembly of lecithin and cholesterol. It was discovered that liposomes improved the water solubility and cellular uptake of rutin in adipocytes. These rutin-loaded liposomes were then incorporated into a microneedle patch (MP) system formed by polyvinylpyrrolidone and poly(vinyl alcohol), and the MP-LR showed an increased release percentage in the adipose tissue microenvironment of pH 6.5 and achieved local delivery of rutin into adipocytes. Next, the therapeutic potentials of rutin, LR, and MP-LR were investigated in a high-fat diet (HFD)-induced obese mouse model. The MP-LR formulation decreased the weight of the HFD mice the most significantly. The antilipogenesis mechanisms of MP-LR are downregulating the lipid synthesis-related proteins (PPAR γ and C/EBP α) in adipocytes and promoting the expression of the beige adipogenesis-related proteins (UCP 1 and Cyt C). The MP systems further promote the local penetration of LR into the adipose tissue specifically, which again elevates their antiobesity effect. Overall, this study suggests that MP-delivered liposome-based formulation is a promising approach to enhance the antiobesity efficacy of antilipogenesis bioactive compounds

Temperature Characteristics and Feasibility Study of Temperature-Sensitive Electrical Parameters under Short-Circuit Conditions for SiC MOSFETs

To address the persistent challenge of thermal stress, the leading cause of SiC MOSFET failure, it is essential to enhance their field robustness and extend their lifespan through precise junction temperature prediction and timely fault protection. Temperature-Sensitive Electrical Parameters (TSEPs) are commonly employed for temperature monitoring; however, they often face limitations such as low resolution and high detection difficulty, which can undermine the accuracy of temperature predictions. Additionally, short circuits represent an extreme condition for temperature rise, and it is imperative to verify the stability of their indicators under high-temperature conditions. This study investigates the temperature dependence of dynamic parameters in SiC MOSFETs under short-circuit scenarios. By comparing TSEPs under normal and short-circuit conditions, a new TSEP is proposed, accompanied by the design of a novel data acquisition circuit for in-situ temperature prediction. Furthermore, this study offers guidance for selecting short-circuit protection sensors, effectively preventing false triggers caused by temperature fluctuations.</p

Mitigating Shoot-Through Currents in Current-Controlled Gate Drivers

This paper proposes an optimized design for constant current source gate drivers (CCGDs) based on current mirrors for improved regulation of the switching traj ectories of SiC MOSFETs. CCGDs implemented using conventional current mirrors are likely subject to shoot-through fault when, which compromises current control and efficiency. The proposed design aims to mitigate shoot-through occurrences, thereby enhancing granularity of the gate current and reducing gate driver power losses, particularly for power switches with small input capacitance, such as SiC MOSFETs and low-current IGBTs. Simulation and experimental results demonstrate the improved performance of the optimized CCGD design, significantly enhancing the efficiency and accuracy of active current source gate drivers.</p

DataSheet1_A cuproptosis-related lncRNA signature-based prognostic model featuring on metastasis and drug selection strategy for patients with lung adenocarcinoma.docx

Introduction: Lung adenocarcinoma is a common cause of mortality in patients with cancer. Recent studies have indicated that copper-related cell death may not occur in the same way as previously described. Long non-coding RNAs (lncRNAs) play a key role in the occurrence and development of tumors; however, the relationship between cuproptosis and lncRNAs in tumorigenesis and lung adenocarcinoma (LUAD) treatment has not been well established. Our study aimed to construct a model to analyze the prognosis of lung adenocarcinoma in patients using a carcinogenesis-related lncRNA (CR) signature.Methods: The transcriptional profiles of 507 samples from The Cancer Genome Atlas were assessed. Cox regression and co-expression analyses, and the least absolute shrinkage and selection operator (LASSO) were used to filter the CR and develop the model. The expression status of the six prognostic CRs was used to classify all samples into high- and low-risk groups. The overall disease-free survival rate was compared between the two groups. The Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes were used to identify the pathways and mechanisms involved in this model. Subsequently, immunotherapy response, sensitivity, and correlation analyses for several anti-tumor medications were performed. In vitro experiments, including qPCR, were conducted in nine lung adenocarcinoma cell lines and 16 pairs of lung adenocarcinoma and para-carcinoma tissues.Results: After confirmation using the ROC curve, patients in the low-risk category benefited from both overall and disease-free survival. Gene Ontology analysis highlighted cell movement in the model. In the in vitro experiments, qPCR results showed the expression levels of six CRs in 16 pairs of carcinoma and para-carcinoma tissues, which were in accordance with the results of the model. AL138778.1 is a protective factor that can weaken the invasion and migration of A549 cells, and AL360270.1 is a hazardous factor that promotes the invasion and migration of A549 cells. According to this model, targeted treatments such as axitinib, gefitinib, linsitinib, pazopanib, and sorafenib may be more appropriate for low-risk patients.Conclusion: Six CR profiles (AL360270.1, AL138778.1, CDKN2A-DT, AP003778.1, LINC02718, and AC034102.8) with predictive values may be used to evaluate the prognosis of patients with lung adenocarcinoma undergoing therapy.</p

Additional file 1 of Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability

Additional file 1. Fig. S1. CNV levels of KDM4B were detected between MGMT methylated and unmethylated statuses.Fig. S2. Effect of KDM4B knockdow on GBM cell growth, proliferation, migration and invasion. (A, B) The qPCR and Western blots were used to detect KDM4B expression in knockdown cells. (C) Relative cell number was measured by phase contrast image analysis after knocking down KDM4B. (D) The BrdU-positive cell percent was measured by BrdU incorporation assays after knocking down KDM4B. (E) Relative colony number was measured by plate clone formation assay after knocking down KDM4B. (F) The migration ability of KDM4B-knockdown GBM cells was measured by the wound healing test. Fig. S3. Effect of KDM4B knockdow on GBM cell cycle. (A) Percentage of indicated U87-MG and LN229 cells in different phase of Fig.4A. (B) Correlation analysis of CDK1 with KDM4B was performed through the GEPIA database. Fig. S4. Relative colony number was measured by plate clone formation assay after restoration of wild-type KDM4B or mutant KDM4B. Fig. S5. Relative colony number was measured by plate clone formation assay after miR-181d-5p was transfected

DataSheet2_An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers.docx

Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved in the tumorigenesis and progression of several cancers. However, its roles on tumor cell proliferation in diverse cancers remain to be elucidated. And there is currently no clinically feasible drug that can directly target YAP in cancers. This research aimed to explore the regulatory mechanism of YAP in promoting tumor proliferation of multiple cancers, in order to find new strategies for inhibiting the overgrowth of YAP-driven cancers.Methods: We investigated the expression pattern of YAP1 in pan-cancer across numerous databases and our cohorts. First, univariate Cox regression analysis and survival analysis were used to evaluate the effect of YAP1 on the prognosis of cancer patients. Second, TIMER was used to explore the relationship between YAP1 expression and tumor cell proliferation. Third, functional and pathway enrichment was performed to search for targets of YAP involved in cell cycle in cancers. At last, GDSC and CCLE datasets were used to assess the correlation between SKP2 expression and MLN4924 IC50 values.Results: Differential expression analysis of multiple databases and qPCR validation showed that YAP1 was generally overexpressed in pan-cancers. Survival analysis revealed that YAP1 over-expression was significantly related to poor prognosis of patients with PAAD. The expression level of YAP1 was positively correlated with the proliferation in varieties of tumors. Further, SKP2 was confirmed as a target of YAP in promoting tumor cell proliferation. In addition, SKP2 expression was negatively correlated with MLN4924 IC50 values in almost all cancer types.Conclusion:YAP1 is frequently overexpressed in human cancers. YAP promoted tumor cell proliferation by up-regulating SKP2 expression in multiple cancers. The comprehensive pan-cancer analysis suggested that inhibition of Skp2 with MLN4924 might be an effective therapeutic strategy for attenuating tumor cell proliferation in YAP-driven cancers.</p

A Fast Short Circuit Detection Method for SiC MOSFETs based on Drain Voltage Swing

Despite the superior performance, Silicon Carbide (SiC) MOSFETs face the challenge of ensuring their effective short circuit (SC) protection due to their lower thermal mass and faster switching speed. A faster and more reliable SC protection method is proposed in this paper based on the Drain-Source voltage (VDS) swing, which enables rapid SC detection and turn-off of the MOSFET before it reaches critical damage levels. The proposed method offers several significant advantages. Firstly, the design achieves ultra-fast detection of both Type-I and Type-II SC types within 150 ns and 24 ns, respectively. Secondly, the method leverages the existing RC snubber circuits typically employed in SiC MOSFET applications to mitigate large switching oscillations and voltage overshoots, ensuring operation within the safe operating area (SOA). The proposed detection approach is seamlessly integrated into the existing RC snubber configuration without altering its primary functionality, enabling simultaneous SC detection and circuit protection. Lastly, a novel sample-and-hold (S/H) circuit is integrated into a digital gate driver at reduced cost, providing adaptability to different operating conditions. A test rig incorporating the proposed SC protection is established to validate its effectiveness and repeatability.</p

DataSheet1_An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers.docx

Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved in the tumorigenesis and progression of several cancers. However, its roles on tumor cell proliferation in diverse cancers remain to be elucidated. And there is currently no clinically feasible drug that can directly target YAP in cancers. This research aimed to explore the regulatory mechanism of YAP in promoting tumor proliferation of multiple cancers, in order to find new strategies for inhibiting the overgrowth of YAP-driven cancers.Methods: We investigated the expression pattern of YAP1 in pan-cancer across numerous databases and our cohorts. First, univariate Cox regression analysis and survival analysis were used to evaluate the effect of YAP1 on the prognosis of cancer patients. Second, TIMER was used to explore the relationship between YAP1 expression and tumor cell proliferation. Third, functional and pathway enrichment was performed to search for targets of YAP involved in cell cycle in cancers. At last, GDSC and CCLE datasets were used to assess the correlation between SKP2 expression and MLN4924 IC50 values.Results: Differential expression analysis of multiple databases and qPCR validation showed that YAP1 was generally overexpressed in pan-cancers. Survival analysis revealed that YAP1 over-expression was significantly related to poor prognosis of patients with PAAD. The expression level of YAP1 was positively correlated with the proliferation in varieties of tumors. Further, SKP2 was confirmed as a target of YAP in promoting tumor cell proliferation. In addition, SKP2 expression was negatively correlated with MLN4924 IC50 values in almost all cancer types.Conclusion:YAP1 is frequently overexpressed in human cancers. YAP promoted tumor cell proliferation by up-regulating SKP2 expression in multiple cancers. The comprehensive pan-cancer analysis suggested that inhibition of Skp2 with MLN4924 might be an effective therapeutic strategy for attenuating tumor cell proliferation in YAP-driven cancers.</p