Additional file 1 of Opioid exposure during pregnancy and the risk of congenital malformation: a meta-analysis of cohort studies

Additional file 1 Table S1. Search terms. Table S2. Summary of risk of bias assessment using ROBINS-I tool. Fig. S1. Eggers’s test of studies examining the association between opioids exposure and the risk of congenital malformations. Fig. S2. Forest plot of association between opioid exposure and major congenital malformation. Fig. S3. Forest plot of association between opioid exposure and central nervous system malformation. Fig. S4. Forest plot of association between opioid exposure and limb malformation. Fig. S5. Forest plot of assoxiation between opioid exposure and cardiovascular malformation. Fig. S6. Forest plot of association between opioid exposure and gastrointestinal malformation. Fig. S7. Forest plot of association between opioid exposure and ear, face, and neck malformation. Fig. S8. Forest plot of association between opioid exposure and respiratory malformation. Fig. S9. Forest plot of association between opioid exposure and musculoskeletal malformation. Fig. S10. Forest plot of association between opioid exposure and urogenital malformation. Fig. S11. Forest plot of association between opioid exposure and orofacial malformation. Fig. S12. Forest plot of association between opioid exposure and neural tube defects. Fig. S13. Forest plot of association between opioid exposure and gastroschisis. Fig. S14. Forest plot of association between opioid exposure and clubfoot. Fig. S15. Meta-regression according to the year of publication. Fig. S16. Forest plot of subgroup analysis of exposed period. Fig. S17. Forest plot of subgroup analysis of indication. Fig. S18: Forest plot of subgroup analysis of adjusted for confounders. Fig. S19. Forest plot of subgroup analysis of risk of bias assessment

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena

Surface Oxidation and Wetting Synergistic Effect of Liquid Metals

Various functions of liquid metals are closely related to their surface performances, among which oxidation and wetting are the two most important surface processes. The two processes of liquid metals are inseparable in most practical applications; however, the coupling of oxidation and wetting of liquid metals has received little attention. Here, we demonstrate the synergistic effect of oxidation and wetting of liquid metals through establishing a liquid system containing the copper ion acid solution. By modulating the concentrations of copper ions and hydrogen ions, three different modes of the liquid metal surface are presented, where the oxidation process and the wetting process are in a competitive relationship. Whichever of the two processes is dominant can determine the stability of copper particles produced on the surface of liquid metals, that is, affect whether the “phagocytosis” process can occur. It is revealed that the magnitude of current density on the surface of liquid metals, caused by galvanic corrosion behavior between liquid metals and copper particles, is the key factor influencing the dominance of different surface processes of liquid metals. Utilizing the synergistic effect, we prepare a liquid metal film with adjustable reflectivity, in which surface states can be changed repeatedly between the bright state and the darken state by simple solution immersion. The liquid metal film with different surface states can show obvious difference in optical performance, which has application potential in color camouflage. Understanding the surface synergistic effect will facilitate further exploration of the abundant exotic liquid metal interface phenomena