6 research outputs found

    Additional file 1 of Association between white blood cell count to hemoglobin ratio and risk of in-hospital mortality in patients with lung cancer

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    Additional file 1: Supplementary Table 1. Sensitivity analysis before and after interpolatio

    FeCl<sub>3</sub>·6H<sub>2</sub>O‑Catalyzed Intramolecular Allylic Amination: Synthesis of Substituted Dihydroquinolines and Quinolines

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    A facile and efficient method to synthesize 2- or 4-substituted 1,2-dihydroquinolines and quinolines catalyzed by FeCl<sub>3</sub>·6H<sub>2</sub>O (2 mol %) was described. The iron-catalyzed intramolecular allylic amination of 2-aminophenyl-1-en-3-ols proceeded smoothly to afford 13 1,2-dihydroquinoline and 8 quinoline derivatives under mild reaction conditions with good to excellent yields (up to 96%)

    Construction of Topological Macromolecular Side Chains Packing Model: Study Unique Relationship and Differences in LC-Microstructures and Properties of Two Analogous Architectures with Well-Designed Side Attachment Density

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    A new series of linear–comb and 4-arm star–comb side chain liquid crystalline polymers (Lc-/Sc-SCLCPs) have been synthesized and characterized. The treatment of hydride siloxane-containing terminated liquid crystalline and high 1,2-/1,4- (high vinyl, hv/low vinyl, lv) linear or 4-arm star polybutadienes (L-/S-PBs) was conducted via the methods in combination of living anionic polymerization and “reverse” hydrosilylation to obtain SCLCPs with wide mesomorphic temperature range (Δ<i>T</i>) and narrow polydispersity index (PDI). The possible molecular arrangement model of two analogous hv-/lv-architectures was constructed, that was used to systematically investigate the effects of Lc- and Sc- topological morphology on liquid crystalline (LC) properties and molecular microstructures. SCLCPs exhibited the same smectic A phase around room temperature, but thermal properties were significantly different due to differences of interaction force resulting from different macromolecular side chains packing. Surprisingly, the trend of lv-SCLCP displaying the effects of topology on phase transitions and microstructures was just contrary to that of hv-topology. hv-Sc-SCLCPs containing high density mesogenic composition were desired to generate wider Δ<i>T</i> and higher molecular layer order in comparison with Lc analogues, which provided a unexpected analyzed model that are of interest to be explored. In particular, the uniaue differences of macromolecular aggregation state arrangement in liquid crystal state dependent on free cooling between hv-Lc- and Sc-SCLCPs were observed from POM

    Additional file 1 of Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling

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    Additional file 1: Fig. S1. The expression of OxtRs in mouse retina. Fig. S2. Example images showing OxtR-eYFP neurons are Brn3a (A) or melanopsin (B) positive in the GCL. Fig. S3. eYFP+ neurons in Oxtr-Cre; Ai3 mice are mainly GABAergic, but not glycinergic amacrine cells. Fig. S4. Distribution of OxtR-eYFP neurons in Oxtr-Cre; Ai3 mouse retina. Fig. S5. ChAT and CRH ACs are partially co-localized with OxtR-eYFP neurons, and oxytocin elevates DA level. Fig. S6. The effects of oxytocin and OxtR antagonist on the amplitude of ERG b-wave. Fig. S7. Effects of oxytocin on b-wave amplitude in the presence of V1AR or DA receptor antagonists

    Postpolymerization Modification of Poly(dihydropyrimidin-2(1<i>H</i>)‑thione)s via the Thiourea–Haloalkane Reaction to Prepare Functional Polymers

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    A highly reactive thiourea-contained polycondensate, poly­(dihydropyrimidin-2­(1<i>H</i>)-thione) (poly­(DHPMT)) has been facilely synthesized via the Biginelli polycondensation using thiourea and a difunctional compound containing benzaldehyde and β-keto ester groups as monomers. The thiourea moiety in the polymer structure has similar reactivity as the thiourea, thus the poly­(DHPMT) is an excellent polymer precusor for preparing new functional polymers through the postpolymerization modification (PPM) strategy. After simple reaction with functional haloalkanes, the parent poly­(DHPMT) could be almost completely converted (>99%) to daughter polymers containing alkene or alkyne side groups. Then, the daughter polymers have been further transferred to granddaughter polymers through another PPM via thiol–ene or Cu­(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reactions. Besides, when 3-phenylpropargyl chloride was used as the reactant, a bright yellow fluorescent polymer could be simply achieved due to the in situ formed conjugated heterocycle in the polymer structure, further demonstrating the diversity of the functional polymers through PPM. Considering the easily available monomers, simple polycondensation, and the excellent reactivity of the thiourea moiety in the polymer structure, this thiourea-contained Biginilli polycondensate might be a versatile platform for new functional polymer preparation
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