Racemic synthesis of an intermediate for the formal synthesis of madindoline A and B

<p>On the basis of the application of the Darzens/ring-expansion process of cyclobutenedione developed previously by our group, a new strategy for the multisubstituted cyclopentene units of madindoline A and madindoline B has been reported in this paper. In light of the strategy, the synthesis of racemic Omura’s intermediate was finished in four steps and 34% overall yield, which furnished a new formal synthetic route to madindolines A and B.</p

Photothermal-Responsive Conjugated Polymer Nanoparticles for the Rapid and Effective Killing of Bacteria

The emergence of drug-resistant bacterial strains makes antimicrobial treatment a big challenge. Thus, more novel and effective antimicrobial agents and treatments are urgently desired. Herein, we developed a facile and rapid photothermal antimicrobial nanoplatform based on near-infrared (NIR)-active and photothermal-responsive conjugated polymer nanoparticles (CPNs) functionalized with cell-penetrating peptide (CPNs-Tat). With a positively charged Tat peptide, CPNs-Tat could enhance the interaction with bacteria cells with the formation of CPNs-Tat/bacteria aggregation. Under NIR irradiation, CPNs-Tat could convert the light into heat efficiently and produce local hyperthermia to kill bacteria within a few minutes. This photothermal-responsive strategy offers a rapid and effective modality for combating bacterial infections

Fluorescence Ratiometric Assay Strategy for Chemical Transmitter of Living Cells Using H₂O₂‑Sensitive Conjugated Polymers

A new water-soluble conjugated poly­(fluorene-<i>co</i>-phenylene) derivative (PFP-FB) modified with boronate-protected fluorescein (peroxyfluor-1) via PEG linker has been designed and synthesized. In the presence of H₂O₂, the peroxyfluor-1 group can transform into green fluorescent fluorescein by deprotecting the boronate protecting groups. In this case, upon selective excitation of PFP-FB backbone at 380 nm, efficient fluorescence resonance energy transfer (FRET) from PFP-FB backbone to fluorescein occurs, and accordingly, the fluorescence color of PFP-FB changes from blue to green. Furthermore, the emission color of PFP-FB and the FRET ratio change in a concentration-dependent manner. By taking advantage of PFP-FB, ratiometric detection of choline and acetylcholine (ACh) through cascade enzymatic reactions and further dynamic monitoring of the choline consumption process of cancer cells have been successfully realized. Thus, this new polymer probe promotes the development of enzymatic biosensors and provides a simpler and more effective way for detecting the chemical transmitter of living cells

Characteristics of Included Studies.

<p>Abbreviations: ED: Erectile dysfunction. IIEF 5 Questionnaire: International Index of Erectile Function (5 Items) Questionnaire.</p

Graphdiyne Materials as Nanotransducer for in Vivo Photoacoustic Imaging and Photothermal Therapy of Tumor

Two-dimensional (2D) all-carbon materials hold great fascination because of their superior properties and promising applications. Herein, we presented the first demonstration for the use of graphdiyne (GDY) as photothermo-acoustic wave nanotransducers for simultaneous effective photoacoustic imaging (PAI) and photothermal therapy (PTT) in living mice. With a large extinction coefficient in near-infrared (NIR) region, upon irradiated by 808 nm laser, GDY not only exhibits a stable photothermal performance with a high photothermal conversion efficiency of 42%, but also provides an excellent photoacoustic response. Owing to its good biocompatibility modified with PEGylation, GDY can be simultaneously used as PAI probe and PTT agent and exhibits an efficient photothermal ablation of cancer cells in living mice. This work opens a new way into the development of 2D graphdiynes as novel theranostic platform for cancer treatment

Light-Triggered Reversible Tuning of Second-Harmonic Generation in a Photoactive Plasmonic Molecular Nanocavity

The ultrasmall mode volume and ultralarge local field enhancement of compact plasmonic nanocavities have been widely explored to amplify a variety of optical phenomena at the nanoscale. Other than passively generating near-field enhancements, dynamic tuning of their intensity and associated nonlinear optical processes such as second-harmonic generation (SHG) play vital roles in the field of active nanophotonics. Here we apply a host–guest molecular complex to construct a photoswitchable molecule-sandwiched metallic particle-on-film nanocavity (MPoFN) and demonstrate both light-controlled linear and nonlinear optical tuning. Under alternating illumination of ultraviolet (UV) and visible light, the photoactive plasmonic molecular nanocavity shows reversible switching of both surface-enhanced Raman scattering (SERS) and plasmon resonance. Surprisingly, we observe more significant modulation of SHG from this photoactive MPoFN, which can be explained qualitatively by the quantum conductivity theory (QCT). Our study could pave the way for developing miniaturized integrated optical circuits for ultrafast all-optical information processing and communication

Additional file 1 of MiR26a reverses enzalutamide resistance in a bone-tumor targeted system with an enhanced effect on bone metastatic CRPC

Supplementary Material

Table_1_COVID-19 pandemic-related depression and anxiety under lockdown: The chain mediating effect of self-efficacy and perceived stress.docx

ObjectiveIn early March 2022, the highly contagious Omicron variant rapidly emerged in Shanghai. This study aimed to explore the prevalence and associated factors of depression and anxiety in isolated or quarantined populations under lockdown.MethodsA cross-sectional study was conducted between May 12 and 25, 2022. The depressive and anxiety symptoms, perceived stress, self-efficacy and perceived social support in the 167 participants under isolated or quarantined were examined using the Patient Health Questionnaires-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Perceived Stress Scale-10 (PSS-10), the General Self-Efficacy Scale (GSES) and the Perceived Social Support Scale (PSSS). Data on demographic information were also collected.FindingsThe prevalence of depression and anxiety in isolated or quarantined populations was estimated to be 12 and 10.8%, respectively. Higher education level, being healthcare workers, being infected, longer duration of segregation and higher perceived stress level were identified as risk factors for depression and anxiety. Furthermore, the relationship between perceived social support and depression (anxiety) was mediated not only by perceived stress but also the chain of self-efficacy and perceived stress.ConclusionBeing infected, higher education level, longer duration of segregation and higher perceived stress were associated with higher levels of depression and anxiety among isolated or quarantined populations under lockdown. The formulation of psychological strategies that promote one’s perceived social support and self-efficacy as well as reduce perceived stress is supposed to be drawn.</p

ARQ 087 activity in tumor growth models.

<p>(A, C, D), Growth is inhibited in BaF3/FGFR2, SNU-16, and NCI-H716, xenograft models, but not inhibited in (B) BaF3/INSR. Results are represented as the mean of tumor volume in mm³ ± SEM of each group (n = 8–10) in function of the treatment period. The tumor growth inhibition (TGI) is indicated on the plots.</p

ARQ 087 biochemical activity.

<p>ARQ 087 biochemical activity.</p