Correct classification rate (CCR), sensitivity, specificity, kappa, and AUC for the final logistic model and autologistic model with 10-fold cross-validation (mean values with range in parentheses).

<p>Correct classification rate (CCR), sensitivity, specificity, kappa, and AUC for the final logistic model and autologistic model with 10-fold cross-validation (mean values with range in parentheses).</p

Percentages of the total variance in red-crowned crane occurrence data explained by habitat and spatial variables at the first hierarchical level.

<p>(a) The variance explained by habitat variables; (b) the variance explained by spatial variables; and (c) the variance explained by combination of habitat and spatial variables.</p

Location of the Yellow River Delta Nature Reserve in China.

<p>'Absence' and 'presence' indicate the absence and presence sampling points of red-crowned cranes. Blue: Yellow River in the YRDNR. Light gray: experimental zones of the YRDNR. Light green: buffer zones of the YRDNR. Dark green: core zones of the YRDNR.</p

Variable parameters for the final autologistic model with a neighborhood size of 8 km.

<p>**: p-value<0.01;</p><p>***: p-value <0.001</p><p>Variable parameters for the final autologistic model with a neighborhood size of 8 km.</p

Habitat suitability map and protection gap for red-crowned cranes used by the final autologistic model.

<p>Red: suitable habitat for the red-crowned crane in the core zone of the YRDNR. Green: suitable habitat for the red-crowned crane outside the core zone of the YRDNR. Blue: Yellow River in the YRDNR. Light gray: experimental zones of the YRDNR. Gray: buffer zones of the YRDNR. Dark gray: core zones of the YRDNR.</p

The landscape index of red-crowned crane suitable habitat in the YRDNR.

<p>North: northern part of the YRDNR; South: southern part of the YRDNR; Total: the entire reserve; CA: total suitable habitat area; PLAND: proportion of suitable habitat area; AREA_MN: average patch area of suitable habitat; PG: protection gap area in the YRDNR; PPG: percentage of protection gap area with total suitable habitat in the YRDNR.</p><p>The landscape index of red-crowned crane suitable habitat in the YRDNR.</p

DataSheet_1_Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells.pdf

Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a sialoside-binding receptor expressed by eosinophils and mast cells that exhibits priming status- and cell type-dependent inhibitory activity. On eosinophils that have been primed with IL-5, GM-CSF, or IL-33, antibody ligation of Siglec-8 induces cell death through a pathway involving the β2 integrin-dependent generation of reactive oxygen species (ROS) via NADPH oxidase. In contrast, Siglec-8 engagement on mast cells inhibits cellular activation and mediator release but reportedly does not impact cell viability. The differences in responses between cytokine-primed and unprimed eosinophils, and between eosinophils and mast cells, to Siglec-8 ligation are not understood. We previously found that Siglec-8 binds to sialylated ligands present on the surface of the same cell (so-called cis ligands), preventing Siglec-8 ligand binding in trans. However, the functional relevance of these cis ligands has not been elucidated. We therefore explored the potential influence of cis ligands of Siglec-8 on both eosinophils and mast cells. De-sialylation using exogenous sialidase profoundly altered the consequences of Siglec-8 antibody engagement on both cell types, eliminating the need for cytokine priming of eosinophils to facilitate cell death and enabling Siglec-8–dependent mast cell death without impacting anti–Siglec-8 antibody binding. The cell death process licensed by de-sialylation resembled that characterized in IL-5–primed eosinophils, including CD11b upregulation, ROS production, and the activities of Syk, PI3K, and PLC. These results implicate cis ligands in restraining Siglec-8 function on eosinophils and mast cells and reveal a promising approach to the selective depletion of mast cells in patients with mast cell-mediated diseases.</p

Percentages of the total variance in red-crowned crane occurrence data explained by plot, patch, and landscape variables at the second hierarchical level; a, b, c are unique effects of plot, patch and landscape variables, respectively; d, e, f, g are fractions indicating their combined effects.

<p>Percentages of the total variance in red-crowned crane occurrence data explained by plot, patch, and landscape variables at the second hierarchical level; a, b, c are unique effects of plot, patch and landscape variables, respectively; d, e, f, g are fractions indicating their combined effects.</p

The percentages of cell subsets in circulating blood pre and post iNO therapy.

<p>Data are presented as medians with 25–75% quartiles. MNC = mononuclear cells.</p

The levels of plasma cytokines at different time points in infants with and without BPD.

<p>VEGF = vascular endothelial growth factor; SDF-1 =  stromal cell-derived factor-1; GM-CSF = granulocyte-macrophage colony-stimulating factor. Data are presented as mean ± SD.</p