How to Promote Logistics Enterprises to Participate in Reverse Emergency Logistics: A Tripartite Evolutionary Game Analysis (original code of simulation)

Considering the emergency risks and uncertainties of emergency recycling processes, this research builds a tripartite evolutionary game model of government, logistics enterprises, and environmental non-governmental organizations (NGOs) to study the interaction mechanism. Based on the analysis of evolutionary stable strategy (ESS), this research uses MATLAB R2018b to mainly show the strategy choice trends of logistics enterprises in various scenarios including “Government Failure”, as well as the mutual impacts of government and environmental NGOs’ strategy selection.   </p

Tandem Isobenzofuran Formation−Diels Alder Reactions in the Coupling of Carbene Complexes with 2-Alkynylbenzaldehyde Derivatives Featuring an Alkyne-Dienophile Tether

The coupling of carbene complexes and 2-alkynylbenzaldehyde derivatives has been examined for systems where the alkyne is further linked to an alkene. This reaction proceeds via generation of an isobenzofuran followed by a stereoselective intramolecular Diels−Alder reaction, followed by opening of the resulting oxanorbornene ring. A variety of hydrophenanthrene derivatives and heterocyclic analogues have been produced in this reaction. In one case the intramolecular Pauson−Khand reaction is a competing process

Membrane Activation: Selective Vesicle Fusion via Small Molecule Recognition

We report herein the induction of selective vesicle fusion with biological recognition motifs not natively associated with lipid bilayer fusion, thus broadening the scope of recognition-guided membrane activation. Our system employs vancomycin glycopeptide, coupled to the antimicrobial peptide magainin, and D-Ala-D-Ala-OH dipeptide coupled to a phospholipid derivative, as surface-bound fusogens. Fusion was characterized by dynamic light scattering and FRET experiments with lipid bound fluorophores. We have demonstrated here that appropriately designed membrane anchored molecular recognition motifs have the biomimetic ability to activate specific membrane mergers; this principle has resonance with goals in targeted chemical delivery and nanoscale compartmentalized chemistry

A Silver-Catalyzed Domino Route toward 1,2-Dihydroquinoline Derivatives from Simple Anilines and Alkynes

A silver-catalyzed domino reaction of simple anilines and alkynes generates 1,2-dihydroquinoline derivatives efficiently

A Silver-Catalyzed Domino Route toward 1,2-Dihydroquinoline Derivatives from Simple Anilines and Alkynes

A silver-catalyzed domino reaction of simple anilines and alkynes generates 1,2-dihydroquinoline derivatives efficiently

Synthesis of Furanophane Derivatives through [8+2]-Cycloaddition of Dienylisobenzofurans and Alkynes

The coupling of various dienylisobenzofurans with dimethyl acetylenedicarboxylate (DMAD) has been examined. In most cases, this reaction proceeds via [8+2]-cycloaddition to afford furan-bridged decatetraene ring systems. The major competing reaction pathway is [4+2]-cycloaddition between DMAD and the isobenzofuran nucleus. Isobenzofuran intermediates were generated using either a chromium carbene-based method or an acid-catalyzed method

Synthesis of Furanophane Derivatives through [8+2]-Cycloaddition of Dienylisobenzofurans and Alkynes

The coupling of various dienylisobenzofurans with dimethyl acetylenedicarboxylate (DMAD) has been examined. In most cases, this reaction proceeds via [8+2]-cycloaddition to afford furan-bridged decatetraene ring systems. The major competing reaction pathway is [4+2]-cycloaddition between DMAD and the isobenzofuran nucleus. Isobenzofuran intermediates were generated using either a chromium carbene-based method or an acid-catalyzed method

Additional file 1 of Competing endogenous RNA network analysis of Turner syndrome patient-specific iPSC-derived cardiomyocytes reveals dysregulation of autosomal heart development genes by altered dosages of X-inactivation escaping non-coding RNAs

Additional file 1. Additional Figures. Figure S1. Karyotypes of the iPSC lines. Karyotypes of (A) the 3 WT-iPSC lines and (B) the 3 TS-iPSC lines. Figure S2. Correlation analyses of mRNA, lncRNA and circRNA expression profiles among the samples. (A) principal component analysis (PCA) and (B) Pearson correlation coefficient (PCC) analysis of mRNA expression profiles among the samples of WT-iPSC, WT-CM, TS-iPSC and TS-CM groups. (C) PCA and (D) PCC analyses of lncRNA expression profiles among the samples. (E) PCA and (F) PCC analyses of circRNA expression profiles among the samples

DataSheet_1_Predictive value of the neutrophil-to-lymphocyte ratio in the prognosis and risk of death for adult sepsis patients: a meta-analysis.pdf

BackgroundThe neutrophil-to-lymphocyte ratio (NLR) is a commonly used biomarker for acute inflammation that often rises during sepsis, making it a valuable diagnostic indicator for clinical practice. However, no consensus has been reached on the prognostic value of NLR for predicting the prognosis and mortality risk in adult sepsis patients. In light of this controversy, we conducted a meta-analysis to clarify the prognostic significance of NLR in adult sepsis patients. The meta-analysis was registered in the PROSPERO database (registration number CRD42023433143).MethodsWe performed a comprehensive literature search in PubMed, Cochrane Library, Ovid, and Springer databases, using retrieval terms “sepsis” or “septic shock” and “prognosis” or “mortality” for studies published between January 1, 2000, and May 31, 2023. Children and neonates with sepsis were excluded from our research. Two independent researchers conducted the literature search and data extraction. Consensus was reached when discrepancies occurred, and in case of persistent discrepancies, the final decision was made by the research supervisor. The hazard ratio (HR) and its corresponding 95% confidence interval (95% CI) were extracted from each study included in the analysis. A random-effects model was used to synthesize all HRs and their 95% CIs. Sensitivity analysis was performed to investigate heterogeneity. Sensitivity analysis was conducted to identify studies that had a significant impact on the overall results of the meta-analysis. Subgroup analysis and meta-regression were performed to explore sources of heterogeneity. Egger’s test was also used to investigate publication bias in this meta-analysis.ResultsAfter a comprehensive literature search and screening, we included 12 studies comprising 10,811 patients for the meta-analysis. The pooled results indicated that patients with a higher NLR level were associated with a poor prognosis (Random-effects model, HR: 1.6273, 95% CI: 1.3951-1.8981). Heterogeneity testing showed significant heterogeneity (I2 = 87.2%, 95% CI: 79.5-92, p2 value. After removing this study, a strong association was found between a higher NLR level and poor prognosis and risk of death in adult sepsis patients (Random-effects model, HR: 1.6884, 95% CI: 1.4338-1.9882). Both subgroup analysis and meta-regression indicated that the study design and testing time of NLR were sources of heterogeneity. Egger’s test showed no obvious publication bias in this meta-analysis.ConclusionNLR is a reliable and valuable biomarker for predicting prognosis and the risk of death in adult sepsis patients.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023433143] PROSPERO, identifier [CRD42023433143].</p

Table_1_Comparison of the safety profile, conversion rate and hospitalization duration between early and delayed laparoscopic cholecystectomy for acute cholecystitis: a systematic review and meta-analysis.DOCX

BackgroundAlthough the past decade has witnessed unprecedented medical progress, no consensus has been reached on the optimal approach for patients with acute cholecystitis. Herein, we conducted a systematic review and meta-analysis to assess the differences in patient outcomes between Early Laparoscopic Cholecystectomy (ELC) and Delayed Laparoscopic Cholecystectomy (DLC) in the treatment of acute cholecystitis. Our protocol was registered in the PROSPERO database (registration number: CRD42023389238).ObjectivesWe sought to investigate the differences in efficacy, safety, and potential benefits between ELC and DLC in acute cholecystitis patients by conducting a systematic review and meta-analysis.MethodsThe online databases PubMed, Springer, and the Cochrane Library were searched for randomized controlled trials (RCTs) and retrospective studies published between Jan 1, 1999 and Jan 1, 2022.Results21 RCTs and 13 retrospective studies with a total of 7,601 cases were included in this research. After a fixed-effects model was applied, the pooled analysis showed that DLC was associated with a significantly high conversion rate (OR: 0.6247; 95%CI: 0.5115–0.7630; z = −4.61, p ConclusionELC represents a safe and feasible approach for acute cholecystitis patients since it shortens hospitalization duration and decreases the incidence of postoperative complications of laparoscopic cholecystectomy.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=389238, identifier (CRD42023389238).</p