Table_1_Factors related to satisfaction with community-based home aging services in Shandong, China.DOCX

PurposeThis study investigated the satisfaction of current community-based home care services and its factors in adults aged ≥60 years.MethodsUsing stratified cluster random sampling, we surveyed 1,494 older adults in Jinan and Qingdao, Shandong province, between 2021 and 2023. The baseline and satisfaction surveys were designed by our research team, and the questionnaires were conducted in the form of structured interviews. Kruskal-Wallis H-test and Logistic regression analysis were used to explore the influencing factors of satisfaction.ResultsThe satisfaction was mainly affected by age (p = 0.007), marital status (p ConclusionThe satisfaction level of community-based home care services is relatively high among older adults, and it is mainly affected by factors such as age, marital status, pre-retirement occupation, source of financial resources, and mode of residence. Addressing the emotional needs of older adults, lowering the cost of aging, and integrating health care and aging seamlessly are among the ongoing challenges that we need to tackle.</p

Near-unity efficiency in ridge waveguide-based, on-chip single-photon sources

We report a numerical design procedure for pursuing a near-unity coupling efficiency in quantum dot-cavity ridge waveguide single-photon sources by performing simulations with the finite element method. Our optimum design which is based on a 1D nanobeam cavity, achieves a high source efficiency $\epsilon_{xy}$ of 97.7$\%$ for an isotropic in-plane dipole, together with a remarkable Purcell factor of 38.6. Such a good performance is mainly attributed to the high index contrast of GaAs/SiO$_2$ and a careful cavity design achieving constructive interference and low scattering losses. Furthermore, we analyze the bottleneck of the proposed platform, which is the mode mismatch between the cavity mode and the Bloch mode in the nanobeam. Accordingly, we present the optimization recipe of an arbitrarily high-efficiency on-chip single-photon source by implementing a taper section, whose high smoothness is beneficial to gradually overcoming the mode mismatch, and therefore leading to a higher Purcell factor and source efficiency. Finally, we see good robustness of the source properties in the taper-nanobeam system under the consideration of realistic fabrication imperfections on the hole variation

Construction of α‑Acyloxy Ketones via Photoredox-Catalyzed O–H Insertion of Sulfoxonium Ylides with Carboxylic Acids

Herein, a photoredox-catalyzed insertion of sulfoxonium ylides with carboxylic acids was advanced under mild and simple conditions, offering a practical approach for preparing α-acyloxy ketones with a broad scope of carboxylic acids. A combined experimental and computational study suggests that this reaction proceeds via a stepwise proton-assisted electron transfer mechanism

Lysophospholipids and lysophospholipid receptors.

(A) Lysophospholipids. (B) Phylogenetic tree of lysophospholipid receptors. Sequence similarity analysis of EDG family receptors, P2Y family receptors, and other lysophospholipid receptors. Multiple sequence alignment was done with MUSCLE. Phylogenetic tree was calculated by neighbor-joining method and displayed by iTOL. EDG family and P2Y family are colored red and green, respectively. (TIF)</p

Functional data of G protein coupling.

(A) Concentration-response curves of GPR34 mutants in the Gi-dissociation assay. (B) Expression of GPR34 mutants in HEK293T cells. (C-E) Details of Gαs binding by GPR174 (C), β2AR (D, PDB: 3sn6), and CCKAR (E, PDB: 7ezk). (F) Concentration-response curves of GPR174 mutants in the cAMP accumulation assay. (G) Expression of GPR174 mutants in CHO cells. All data represent mean ± SEM from at least 3 independent experiments. The data used to generate graphs in S6A, S6B, S6F, and S6G are available in S1 Data. (TIF)</p

Visible-Light Photocatalyzed C3–H Alkylation of 2<i>H</i>‑Indazoles/Indoles with Sulfoxonium Ylides via Diversified Mechanistic Pathways

Herein, the C3–H alkylation of 2H-indazoles and indoles with sulfoxonium ylides is developed under visible-light photocatalysis. This protocol employs easily accessible reagents, and a wide range of 2H-indazoles, indoles, and sulfoxonium ylides are suitable for this reaction to afford the desired products under benign conditions. Synergistic experimental and computational studies suggest that the sulfoxonium ylides involving C3–H alkylation of 2H-indazoles and indoles under visible-light photocatalysis could proceed via different mechanistic pathways. For the C3-alkylation of 2H-indazoles, a triplet energy transfer mechanistic pathway of 2H-indazoles is proposed for quenching the excited photocatalyst. Subsequently, the formed excited triplet state of 2H-indazoles could undergo radical attack on the CS moiety of sulfoxonium ylides. After the dissociation of DMSO and 1,2-H migration, the final product of C3-alkylation of 2H-indazoles could be yielded. However, such a mechanistic pathway is not applicable for indoles. Instead, sulfoxonium ylides could be converted to a C-centered radical in the presence of KH2PO4 under visible-light photoredox conditions. The formed C-centered radical can attack the C3-site of indoles and thus lead to the C3-alkylation product of indoles

Data used for graphs in Figs 2B, 2D, 5E, 5J, S4A–S4E, S5A–S5D, S6A, S6B, S6F and S6G.

Data used for graphs in Figs 2B, 2D, 5E, 5J, S4A–S4E, S5A–S5D, S6A, S6B, S6F and S6G.</p

Comparison of LysoPS recognition by GPR34 and GPR174.

(A) Interactions between GPR174 and the polar head of LysoPS (18:0) or LysoPS (18:1). (B) Interactions between GPR174 and the acyl tail of LysoPS (18:0) or LysoPS (18:1). The double bond of LysoPS (18:1) is colored red; the corresponding single bond in LysoPS (18:0) is colored orange. (C) Charged interactions between LysoPS and GPR34 in the positively charged pocket. (D) Charged interactions between LysoPS and GPR174 in the positively charged pocket. (E) Structural superposition of LysoPS bound GPR34 and GPR174 (extracellular view). (F) Comparison between acyl tails of LysoPS binding in GPR34 and GPR174. Polar or charged interactions are depicted as black dashed lines.</p

Topologically protected strong coupling and entanglement between distant quantum emitters

The realization of robust strong coupling and entanglement between distant quantum emitters (QEs) is very important for scalable quantum information processes. However, it is hard to achieve it based on conventional systems. Here, we propose theoretically and demonstrate numerically a scheme to realize such strong coupling and entanglement. Our scheme is based on the photonic crystal platform with topologically protected edge state and zero-dimensional topological corner cavities. When the QEs are put into topological cavities, the strong coupling between them can be fulfilled with the assistance of the topologically protected interface state. Such a strong coupling can maintain a very long distance and be robust against various defects. Especially, we numerically prove that the topologically protected entanglement between two QEs can also be realized. Moreover, the duration of quantum beats for such entanglement can reach several orders longer than that for the entanglement in a conventional photonic cavity, making it be very beneficial for a scalable quantum information process

GPR34-Gi complex preparation and cryo-EM data processing.

(A) Cryo-EM image processing workflow for GPR34-Gi complex. (B) SDS-PAGE profile of GPR34-Gi-scFv16 complex. Uncropped gel for S2B is provided in S1 Raw Images. (C) Representative cryo-EM image (scale bar: 50 nm). (D) Representative 2D class averages (scale bar: 5 nm). (E) Angular distribution plot of final particles. (F) The “gold-standard” FSC curves of the GPR34-Gi-scFv16 complex. (G) Cryo-EM density maps and models of the 7 transmembrane helices (TM1-7), Helix 8 (H8), α5 helix of Gαi, and the ligand of LysoPS 18:1 bound GPR34-Gi complex are shown. The EM density is shown at the threshold of 0.3. (TIF)</p