578 research outputs found

    The practice effect of the methods of colleges and universities cooperation in training primary specialized nurses

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    目的  探讨院校合作模式培养初级专科护士的实践效果。方法  对7所医院2011年注册护士113名采用普通培养方法和2012年注册护士119名,采用院校合作方式进行培养,通过学生考核成绩、教师评分、满意度调查评价分析院校合作方式培养初级专科护士的实践效果。结果  2012年注册护士的平均考核成绩和教师评分比2011年显著增高,并且学生对院校合作培养模式的平均满意度大大提高。结论  院校合作培养模式有利于专科护士对理论知识的吸收、能提高临床实践的操作水平,得到了护士的认可。Objective: To study the practice effect of the methods of colleges and universities cooperation in training primary specialized nurses. Methods: A total of 113 nurses from 7 hospitals, who had been registered in the year of 2011, were trained by common method, and 119 registered nurses in 2012 were trained by colleges and universities cooperation method. Analyze the practice effect of the methods of colleges and universities cooperation in training primary specialized nurses through the examination result, teachers’ assessment, and satisfaction survey. Results: The average examination scores and teacher evaluation result of the students in grade 2012is significantly higher than the students in grade 2011, and the satisfaction of students to the cultivating methods of Colleges and universities cooperation is also greatly improved. Conclusion: The cultivating methods of Colleges and universities cooperation are not only beneficial for primary specialized nurses to master theory knowledge and improve the clinic operative level, but also obtain the recognition of students

    Lifshitz transitions in a heavy-Fermion liquid driven by short-range antiferromagnetic correlations in the two-dimensional Kondo lattice model

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    The heavy-Fermion liquid with short-range antiferromagnetic correlations is carefully considered in the two-dimensional Kondo-Heisenberg lattice model. As the ratio of the local Heisenberg superexchange JHJ_{H} to the Kondo coupling JKJ_{K} increases, Lifshitz transitions are anticipated, where the topology of the Fermi surface (FS) of the heavy quasiparticles changes from a hole-like circle to four kidney-like pockets centered around (π,π)(\pi ,\pi). In-between these two limiting cases, a first-order quantum phase transition is identified at JH/JK=0.1055J_{H}/J_{K}=0.1055 where a small circle begins to emerge within the large deformed circle. When JH/JK=0.1425J_{H}/J_{K}=0.1425, the two deformed circles intersect each other and then decompose into four kidney-like Fermi pockets via a second-order quantum phase transition. As JH/JKJ_{H}/J_{K} increases further, the Fermi pockets are shifted along the direction (π,π\pi,\pi) to (π/2,π/2\pi/2,\pi/2), and the resulting FS is consistent with the FS obtained recently using the quantum Monte Carlo cluster approach to the Kondo lattice system in the presence of the antiferrmagnetic order.Comment: 4 pages, 5 figure

    A novel decentralized economic operation in islanded AC microgrids

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    Droop schemes are usually applied to the control of distributed generators (DGs) in microgrids (MGs) to realize proportional power sharing. The objective might, however, not suit MGs well for economic reasons. Addressing that issue, this paper proposes an alternative droop scheme for reducing the total active generation costs (TAGC). Optimal economic operation, DGs’ capacity limitations and system stability are fully considered basing on DGs’ generation costs. The proposed scheme utilizes the frequency as a carrier to realize the decentralized economic operation of MGs without communication links. Moreover, a fitting method is applied to balance DGs’ synchronous operation and economy. The effectiveness and performance of the proposed scheme are verified through simulations and experiments

    Activation of a-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress

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    International audienceActivation of a-7 nicotinic acetylcholine receptor (a-7 nAchR) has a neuro-protective effect on ischemic and hemorrhagic stroke. However, the underlying mechanism is not completely understood. We hypothesized that a-7 nAchR agonist protects brain injury after ischemic stroke through reduction of pro-inflammatory macrophages (M1) and oxidative stress. C57BL/6 mice were treated with PHA568487 (PHA, a-7 nAchR agonist), methyllycaconitine (MLA, nAchR antagonist), or saline immediately and 24 hours after permanent occlusion of the distal middle cerebral artery (pMCAO). Behavior test, lesion volume, CD68 + , M1 (CD11b + /Iba1 +) and M2 (CD206/Iba1 +) microglia/macrophages, and phosphorylated p65 component of NF-kB in microglia/macrophages were quantified using histological stained sections. The expression of M1 and M2 marker genes, anti-oxidant genes and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase were quantified using real-time RT-PCR. Compared to the saline-treated mice, PHA mice had fewer behavior deficits 3 and 7 days after pMCAO, and smaller lesion volume, fewer CD68 + and M1 macrophages, and more M2 macrophages 3 and 14 days after pMCAO, whereas MLA's effects were mostly the opposite in several analyses. PHA increased anti-oxidant genes and NADPH oxidase expression associated with decreased phosphorylation of NF-kB p65 in microglia/macrophages. Thus, reduction of inflammatory response and oxidative stress play roles in a-7 nAchR neuro-protective effect

    Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice

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    Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1® mice were subjected to moderate aerobic exercise (45 min swimming per day with 3% body weight workload) and fed a chow diet with 5% leucine or 3.4% alanine for 8 weeks. Serum and plasma were prepared for glucose, urea nitrogen, insulin and amino acid profile analysis. The white gastrocnemius muscles were used for determination of muscle size and signaling proteins involved in protein synthesis and degradation. The results show that both 8 weeks of leucine supplementation and aerobic training elevated the activity of mTOR (mammalian target of rapamycin) and its downstream target p70S6K and 4E-BP1, inhibited the ubiquitin-proteasome system, and increased fiber cross-sectional area (CSA) in white gastrocnemius muscle. Moreover, leucine supplementation in combination with exercise demonstrated more significant effects, such as greater CSA, protein content and altered phosphorylation (suggestive of increased activity) of protein synthesis signaling proteins, in addition to lower expression of proteins involved in protein degradation compared to leucine or exercise alone. The current study shows moderate aerobic training combined with 5% leucine supplementation has the potential to increase muscle size in fast-twitch skeletal muscle during aging, potentially through increased protein synthesis and decreased protein breakdown

    Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice

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    Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1® mice were subjected to moderate aerobic exercise (45 min swimming per day with 3% body weight workload) and fed a chow diet with 5% leucine or 3.4% alanine for 8 weeks. Serum and plasma were prepared for glucose, urea nitrogen, insulin and amino acid profile analysis. The white gastrocnemius muscles were used for determination of muscle size and signaling proteins involved in protein synthesis and degradation. The results show that both 8 weeks of leucine supplementation and aerobic training elevated the activity of mTOR (mammalian target of rapamycin) and its downstream target p70S6K and 4E-BP1, inhibited the ubiquitin-proteasome system, and increased fiber cross-sectional area (CSA) in white gastrocnemius muscle. Moreover, leucine supplementation in combination with exercise demonstrated more significant effects, such as greater CSA, protein content and altered phosphorylation (suggestive of increased activity) of protein synthesis signaling proteins, in addition to lower expression of proteins involved in protein degradation compared to leucine or exercise alone. The current study shows moderate aerobic training combined with 5% leucine supplementation has the potential to increase muscle size in fast-twitch skeletal muscle during aging, potentially through increased protein synthesis and decreased protein breakdown

    Hierarchical TiO2/C nanocomposite monoliths with a robust scaffolding architecture, mesopore-macropore network and TiO2-C heterostructure for high-performance lithium ion batteries.

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    Engineering hierarchical structures of electrode materials is a powerful strategy for optimizing the electrochemical performance of an anode material for lithium-ion batteries (LIBs). Herein, we report the fabrication of hierarchical TiO2/C nanocomposite monoliths by mediated mineralization and carbonization using bacterial cellulose (BC) as a scaffolding template as well as a carbon source. TiO2/C has a robust scaffolding architecture, a mesopore-macropore network and TiO2-C heterostructure. TiO2/C-500, obtained by calcination at 500 °C in nitrogen, contains an anatase TiO2-C heterostructure with a specific surface area of 66.5 m(2) g(-1). When evaluated as an anode material at 0.5 C, TiO2/C-500 exhibits a high and reversible lithium storage capacity of 188 mA h g(-1), an excellent initial capacity of 283 mA h g(-1), a long cycle life with a 94% coulombic efficiency preserved after 200 cycles, and a very low charge transfer resistance. The superior electrochemical performance of TiO2/C-500 is attributed to the synergistic effect of high electrical conductivity, anatase TiO2-C heterostructure, mesopore-macropore network and robust scaffolding architecture. The current material strategy affords a general approach for the design of complex inorganic nanocomposites with structural stability, and tunable and interconnected hierarchical porosity that may lead to the next generation of electrochemical supercapacitors with high energy efficiency and superior power density.Sincere gratitude goes to funding agencies for financially support: Y. Xu to NNSF China (2117 1067, 21373100), Jilin Provincial Talent Fund (802110000412) and Tang Aoqing Professor Fund of Jilin University (450091105161). T. Hasan to the Royal Academy of Engineering Research Fellowship. B.L. Su to the Thousand Talents Program of China (“Expert of the State” position), Clare Hall Life Membership at the Clare Hall College and the financial support of the Department of Chemistry, University of Cambridge, L.H. Chen and Y. Li to the Department of Education of Hubei Province for “Chutian Scholar” program, NNSF China (21301133), Hubei Natural Science Foundation (2014CFB1 60, 2015CFB428) and the financial support of SRF for ROCS (SEM [2015]311).This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via https://doi.org/10.1039/C5NR09149

    The relationship between obesity associated weight-adjusted waist index and the prevalence of hypertension in US adults aged ≥60 years: a brief report

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    ObjectivesThe main objective was to examine the relationship between weight-adjusted waist index (WWI) and the prevalence of hypertension among individuals aged ≥60 years who participated in the NHANES between 2011 and 2018 years.MethodsThe data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. In this population-based study, we focused on participants who were over 60 years old. Data were collected from the aforementioned survey, and the variable of interest was WWI, which was calculated as waist (cm) divided by the square root of body weight (kg). Multivariable logistic regression model was applied to calculate adjusted ORs with 95% CIs in order to explore any possible correlation between WWI and the prevalence of hypertension. Subgroup analysis were used to verify the stability of the relationship between WWI and the prevalence of hypertension. The interaction tests were also conducted in this research.ResultsResults revealed that adults aged ≥60 years who were in the highest WWI quartile had significantly higher chances of developing hypertension when compared to those in the lowest quartile, after adjusting for covariates and potential confounders (p < 0.001).ConclusionThese findings suggest that there is a strong correlation between elevated levels of WWI and the risk of developing hypertension among older adults. As such, WWI could serve as a unique and valuable biomarker for identifying hypertension risk at an earlier stage in the older adults population

    A general and efficient synthesis of pyrazoles catalyzed by Sc(OTf)3 under solvent-free conditions

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    Pyrazoles were prepared in excellent yields via solventless condensation of various 1,3-diketones (R¹COCHXCOCH3, R¹ = Me, Ph; X = H, Me, Cl) and hydrazines, acylhydrazines or sulfonyl hydrazines in the presence of a catalytic amount of Sc(OTf)3 at room temperature. Additionally, the catalyst could be recovered easily after the reactions and reused without evident loss in activity
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