DataSheet1_In-situ reconstruction of CoBOx enables formation of Co for synthesis of benzylamine through reductive amination.docx

Cobalt (Co) as a substitute of noble-metal catalysts shows high catalytic capability for production of the widely used primary amines through the reductive amination. However, the synthesis of Co catalysts usually involves the introduction of organic compounds and the high-temperature pyrolysis, which is complicated and difficult for large-scale applications. Herein, we demonstrated a facile and efficient strategy for the preparation of Co catalysts through the in situ reconstruction of cobalt borate (CoBOx) during the reductive amination, delivering a high catalytic activity for production of benzylamine from benzaldehyde and ammonia. Initially, CoBOx was transformed into Co(OH)2 through the interaction with ammonia and subsequently reduced to Co nanoparticles by H2 under the reaction environments. The in situ generated Co catalysts exhibited a satisfactory activity and selectivity to the target product, which overmatched the commonly used Co/C, Pt or Raney Ni catalysts. We anticipate that such an in situ reconstruction of CoBOx by reactants during the reaction could provide a new approach for the design and optimization of catalysts to produce primary amines.</p

Morphology and mitochondrial genome of <i>C. chinensis</i> and <i>C. taiwanicus</i>.

<p>The H and L strands were designated according to molecular weight, and the H strand is indicated by arrows. The protein and rRNA gene coding sequences are marked with arrows indicating the directions of transcription. All genes have standard nomenclature including tRNA genes, which are designated by the one-letter code for the corresponding amino acid, with numerals differentiating each of the leucine, serine and phenylalanine-specifying tRNA (L1, L2 and L3 for codon families CUN, UUR and UUR, respectively; S1 and S2 for codon families AGN and UCN, respectively; F1 and F2 for condon family UUY). The additional tRNA genes of <i>C. chinensis</i> are marked on the inside of the figure.</p

Additional file 1 of Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape

Additional file 1

The Complete Mitochondrial Genomes of Two Octopods <i>Cistopus chinensis</i> and <i>Cistopus taiwanicus</i>: Revealing the Phylogenetic Position of the Genus <i>Cistopus</i> within the Order Octopoda

<div><p>In the present study, we determined the complete mitochondrial DNA (mtDNA) sequences of two species of <i>Cistopus</i>, namely <i>C. chinensis</i> and <i>C. taiwanicus</i>, and conducted a comparative mt genome analysis across the class Cephalopoda. The mtDNA length of <i>C. chinensis and C. taiwanicus</i> are 15706 and 15793 nucleotides with an AT content of 76.21% and 76.5%, respectively. The sequence identity of mtDNA between <i>C. chinensis and C. taiwanicus</i> was 88%, suggesting a close relationship. Compared with <i>C. taiwanicus</i> and other octopods, <i>C. chinensis</i> encoded two additional tRNA genes, showing a novel gene arrangement. In addition, an unusual 23 poly (A) signal structure is found in the ATP8 coding region of <i>C. chinensis</i>. The entire genome and each protein coding gene of the two <i>Cistopus</i> species displayed notable levels of AT and GC skews. Based on sliding window analysis among Octopodiformes, ND1 and DN5 were considered to be more reliable molecular beacons. Phylogenetic analyses based on the 13 protein-coding genes revealed that <i>C. chinensis and C. taiwanicus</i> form a monophyletic group with high statistical support, consistent with previous studies based on morphological characteristics. Our results also indicated that the phylogenetic position of the genus <i>Cistopus</i> is closer to <i>Octopus</i> than to <i>Amphioctopus</i> and <i>Callistoctopus</i>. The complete mtDNA sequence of <i>C. chinensis and C. taiwanicus</i> represent the first whole mt genomes in the genus <i>Cistopus</i>. These novel mtDNA data will be important in refining the phylogenetic relationships within Octopodiformes and enriching the resource of markers for systematic, population genetic and evolutionary biological studies of Cephalopoda.</p> </div

Inferred phylogenetic relationships among the cephalopods based on mitochondrial DNA sequences.

<p>The concatenated amino acid sequences of 13 protein-coding genes were analyzed ML, NJ, MP and TNT analysis, using <i>Nautilus macromphalus</i> as outgroup. The number at each node is the bootstrap probability of ML analyses. Bootstrap values generated from 1000 replicates for NL, MP and TNT analysis, while 100 replicates for ML analysis. </p

Datasheet1_Association of urinary bisphenol A levels with heart failure risk in U.S. adults from the NHANES (2003–2016).docx

IntroductionAlthough heart failure (HF) has been linked to bisphenol A (BPA), few studies have investigated the cut-off values for the effects of urinary BPA levels on heart failure risk. The association between urinary BPA levels and HF prognosis has not been investigated.MethodsThis study included 11,849 adults over 20 years old using information from the National Health and Nutrition Examination Survey (NHANES), which was conducted from 2003 to 2016. The relationship between urinary BPA levels and the risk of HF was determined via a multivariable logistic regression model, and restricted cubic spline (RCS) methods were used to determine the cut-off for the effect of BPA levels on HF risk. Based on the available NT-proBNP concentration data from the NHANES (2003–2004), multivariable linear regression was applied to determine the linear association between the NT-proBNP concentration and urinary BPA concentration.ResultsThe results revealed a positive correlation between a urinary BPA concentration in the fourth quartile and the occurrence of heart failure [OR 1.49, 95% CI (1.09, 2.04), p = 0.012]. A one-unit increase (1 ng/mg creatinine) in the ln-transformed BPA concentration was linked to a 15% increase in the incidence of HF [OR 1.15, 95% CI (1.03, 1.29), p = 0.014]. The cut-off urinary BPA concentration for HF risk was 1.51 ng/mg creatinine. There was a positive correlation between urinary BPA and NT-proBNP concentrations [β = 0.093, 95% CI (0.014, 0.171), p = 0.02] in males, but there was no linear association [β = 0.040, 95% CI (−0.033, 0.113), p = 0.283] in females.DiscussionIncreased urinary BPA levels are linked to an increased risk of heart failure and poor prognosis. There is a significant increase in the risk of heart failure if the urinary concentration of BPA exceeds 1.51 ng/mg creatinine.</p

Application of “Hydrogen-Bonding Interaction” in Drug Design. Part 2: Design, Synthesis, and Structure–Activity Relationships of Thiophosphoramide Derivatives as Novel Antiviral and Antifungal Agents

On the basis of the structure of natural product harmine, lead compound <b>18</b>, and the structure of compounds in part 1, a series of thiophosphoramide derivatives <b>1</b>–<b>17</b> were designed and synthesized from various amines in one step. Their antiviral and antifungal activities were evaluated. Most of the compounds showed significantly higher antiviral activity against tobacco mosaic virus (TMV) than commercial virucide ribavirin. Compound (<i>R</i>,<i>R</i>)-<b>17</b> showed the best anti-TMV activity <i>in vitro</i> (70%/500 μg/mL and 33%/100 μg/mL) and <i>in vivo</i> (inactivation effect, 68%/500 μg/mL and 30%/100 μg/mL; curative effect, 64%/500 μg/mL and 31%/100 μg/mL; protection effect, 66%/500 μg/mL and 31%/100 μg/mL), which is higher than that of ningnanmycin and lead compound <b>18</b>. The antiviral activity of (<i>R</i>,<i>R</i>)-<b>17</b>·HCl is about similar to that of (<i>R</i>,<i>R</i>)-<b>17</b>. However, the antifungal activity of (<i>R</i>,<i>R</i>)-<b>17</b>·HCl against Puccinia sorghi is slightly lower than that of (<i>R</i>,<i>R</i>)-<b>17</b>. The systematic study provides compelling evidence that these simple thiophosphoramide compounds could become efficient antiviral and antifungal agents

Separation and Characterization of Phenolic Compounds from U.S. Pecans by Liquid Chromatography–Tandem Mass Spectrometry

The phenolic acids and proanthocyanidins (PACs) of pecans possess bioactive properties, which might be useful in retarding the onset of and ameliorating the status of certain chronic disease states. There is a general lack of information in the literature regarding such compounds, especially the PACs. Crude phenolic extracts pooled from eight commercially significant cultivars were selected based on their relatively high antioxidant capacities. The pooled extracts were separated via Sephadex LH-20 column chromatography into five ethanolic low-molecular-weight (LMW) fractions and one acetonic high-molecular-weight (HMW) fraction. The preparations were then characterized using RP-HPLC-ESI-MS/MS and diol-phase HPLC-ESI-MS/MS in order to determine the key constituents present in the LMW and HMW fractions, respectively. As previously observed in pecan nutmeat, ellagic acid and (+)-catechin were found to be the major phenolics in the LMW fractions. The last eluting LMW fraction did not contain phenolic acids; rather it possessed PAC monomers and dimers. The HMW fraction comprised a majority of its PACs as dimers; yet, monomers, trimers, tetramers, pentamers, and hexamers were also separated and characterized

Pressure Regulations on the Surface Properties of CeO₂ Nanorods and Their Catalytic Activity for CO Oxidation and Nitrile Hydrolysis Reactions

Surface properties of nanoscale CeO₂ catalysts in terms of the surface Ce³⁺ fraction and concentration of oxygen vacancy can affect their catalytic performance significantly. Continual adjustment on surface properties of CeO₂ with the morphological preservation has not been realized by synthetic methods. The revisited studies show that surface properties of CeO₂ nanorods can be effectively regulated by synthetic pressures while the rodlike morphology is well-preserved. Such phenomena are ascribed to the contact possibility between Ce³⁺ species and dissolved O₂, which is balanced by the rapidly increased and gradually saturated dissolution/recrystallization rate of Ce­(OH)₃ and linearly increased concentration of dissolved O₂ with the increase of total air pressure or partial pressure of O₂. Surface-property-dependent catalytic activity of CeO₂ nanorods synthesized under various pressures was also demonstrated in two benchmark reactionscatalytic oxidation of CO and hydrolysis of nitrile. Such a finding of the pressure regulation on the reducible metal oxides provides an effective approach to rationally design novel catalysts for specific reactions, where ceria are supports, promoters, or actives

Amine-Modulated/Engineered Interfaces of NiMo Electrocatalysts for Improved Hydrogen Evolution Reaction in Alkaline Solutions

The interface between electrolytes and electrocatalysts would largely determine their corresponding activity and stability. Herein, modulating the surface characteristics of NiMo nanoparticles by various adsorbed amines gives the tunability on their interfacial properties and subsequently improves their catalytic performance for hydrogen evolution reaction (HER) in alkaline solutions. Diamines can significantly improve their HER activity by decreasing the charge-transfer resistance and modulating the electronic structures of interfacial active sites. Importantly, among various amines, ethylenediamine facilitates the HER activity of NiMo with a remarkable decrease of 268 mV in the overpotential to reach 10 mA cm^–2 as compared with that of the unmodified NiMo in 1.0 M KOH. This method provides a novel strategy of regulating the interfacial properties to strengthen the catalytic performance of electrocatalysts