Determination of the genetic effects of <i>IL4RA</i> polymorphisms on asthma and subgroup analysis.

<p>Bonferroni correction was applied (<i>P</i><0.00714). vs., versus; R, random-effects model; F, fixed-effects model; HWE, Hardy-Weinberg equilibrium.</p

Characteristics of the case-control studies included in meta-analysis.

*<p>Different data could be separately extracted.</p><p>NA, not available.</p

Distribution of <i>IL4RA</i> I50V and Q551R polymorphisms among patients and controls.

<p>HWE, Hardy-Weinberg equilibrium.</p

Association between <i>Interleukin-4 Receptor α Chain</i> (<i>IL4RA</i>) I50V and Q551R Polymorphisms and Asthma Risk: An Update Meta-Analysis

<div><p>Background</p><p>The associations between the <i>interleukin-4 receptor α chain</i> (<i>IL4RA</i>) I50V and Q551R polymorphisms and asthma risk remained controversial.</p><p>Methods</p><p>We searched the Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases for studies published before February 2013. The strengths of the associations were calculated using odds ratios (ORs) with 95% confidence intervals (CIs).</p><p>Results</p><p>A total of 50 studies were included in this meta-analysis. There was a significant association between the <i>IL4RA</i> I50V polymorphism and asthma risk in a dominant genetic model (OR = 1.13, 95% CI 1.04–1.23, <i>P</i> = 0.005). The <i>IL4RA</i> Q551R polymorphism was associated with a significantly elevated asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.22–1.75, <i>P</i><0.0001). Subgroup analyses found that the <i>IL4RA</i> I50V polymorphism was significantly associated with asthma risk in Asians (OR = 1.72, 95% CI 1.31–2.25, <i>P</i><0.0001), pediatric asthma risk (OR = 1.50, 95% CI 1.13–1.99, <i>P</i> = 0.005), and atopic asthma risk (OR = 1.88, 95% CI 1.27–2.79, <i>P</i> = 0.002).</p><p>Conclusions</p><p>The results of this meta-analysis suggested that the <i>IL4RA</i> I50V and Q551R polymorphisms may be risk factors for developing asthma.</p></div

Meta-analysis for the association between asthma risk and the <i>IL4RA</i> I50V polymorphism.

<p>Meta-analysis for the association between asthma risk and the <i>IL4RA</i> I50V polymorphism.</p

Flow of study identification, inclusion, and exclusion.

<p>Flow of study identification, inclusion, and exclusion.</p

Meta-analysis for the association between asthma risk and the <i>IL4RA</i> R551Q polymorphism.

<p>Meta-analysis for the association between asthma risk and the <i>IL4RA</i> R551Q polymorphism.</p