Integration strategies of luxury rental operations: is it wise to operate with the manufacturer or co-operate with the competitor?

Luxury rental operations are increasingly popular nowadays. In this study, we develop game-theoretical models to examine the optimal renter’s integration strategies (RISs) in a luxury supply chain with conspicuous consumers. The luxury supply chain consists of one manufacturer, one seller and one renter. Based on observed industrial practices, we compare three RISs, namely non-integration (the renter works on his own), vertical integration (the renter operates with the manufacturer) and horizontal integration (the renter co-operates with the seller). The main findings are as follows. First, integration is not always a wise strategy for the renter. When the proportion of conspicuous consumers (PCC) is sufficiently high, the renter should work on his own. When the PCC is lower than a threshold, the optimal RIS depends on the trade-off between the double-marginalisation and retail competition effects. Second, we evaluate the environmental impacts of RISs and uncover that the environmental effects depend on the product types’ environmental impact. We further identify the conditions how a dominating situation with respect to profitability and environmental impact can be achieved (called ‘PE dominating’). Third, we investigate the effects of consumer segmentation on the optimal RIS. Managerial implications are discussed.</p

Tracing Microbial Production and Consumption Sources of N₂O in Rivers on the Qinghai-Tibet Plateau via Isotopocule and Functional Microbe Analyses

Nitrous oxide (N2O), a potent greenhouse gas, is produced in rivers through a series of microbial metabolic pathways. However, the microbial source of N2O production and the degree of N2O reduction in river systems are not well understood and quantified. This work investigated isotopic compositions (δ15N-N2O and δ18O-N2O) and N2O site preference as well as N2O-related microbial features, thereby differentiating the importance of nitrification, denitrification, and N2O reduction in controlling N2O emissions from five rivers on the eastern Qinghai-Tibet Plateau (EQTP). The average N2O concentration in overlying water (15.2 nmol L−1) was close to that in porewater (17.5 nmol L−1), suggesting that both overlying water and sediment are potentially important sources of N2O. Canonical and nitrifier denitrification dominated riverine N2O production, with contribution being approximately 90%. Nitrification is a non-negligible source of N2O production, and N2O concentration was positively correlated with nitrification genetic potential. The degree of N2O reduction ranged from 78.1 to 94.1% (averaging 90%), significantly exceeding the reported values (averaging 70%) in other freshwaters, which was attributed to the higher ratios of organic carbon to nitrogen and lower ratio of (nirS + nirK)/nosZ in EQTP rivers. This study indicates that a combination of isotopic and isotopocule values with functional microbe analysis is useful for quantifying the microbial sources of N2O in rivers, and the intense microbial reduction of N2O significantly accounts for the low N2O emissions observed in EQTP rivers, suggesting that both the production and consumption of N2O in rivers should be considered in the future

MOESM1 of “Same difference”: comprehensive evaluation of four DNA methylation measurement platforms

Additional file 1. Table S1. Library input details. Table S2. Target region properties and CpGs covered. Table S3. Sequencing details. Figure S1. Number of CpG-units covered, Mean and median coverage per CpG-unit. Figure S2. Intra- and Inter-platform CpG-unit overlap and methylation levels concordance. Table S4. Intra- and Inter-platform details. Figure S3. Overlap of exon annotation of CpG-units as UpSet plot. Figure S4. Overlap of intron annotation of CpG-units as UpSet plot. Figure S5. Overlap of promoters annotation of CpG-units as UpSet plot. Figure S6. Overlap of CpG island annotation of CpG-units as UpSet plot. Figure S7. Overlap CpG shores annotation of CpG-units as UpSet plot. Figure S8. Overlap of unannotated CpG-units as UpSet plot

Supplemental Figure 1

Western blot analysis revealed that the protein expression of MMP10 between these two cells is comparable

Supplementary Table 7 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

XLS file - 74K, DNA methylation and gene expression signature of BCR-ABL1-positive B-ALL</p

Supplementary Table 2 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

XLS file - 60K, Characteristics of the 215 E2993 B-ALL patients and the 12 normal bone marrow samples (excel file)</p

Supplementary Table 15 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

XLS file - 204K, Genomic regions enriched in MLLN, AF4C, H3K79me2 and the common of the three ChIP-seq in RS4;11 cells</p

Supplementary Table 13 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

XLS file - 176K, DNA methylation and gene expression signature of MLLr ALL</p

Supplementary Table 6 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

XLS file - 45K, Detailed genes in the lymphoid gene sets and gene ontology terms</p

Supplementary Tables 1, 3, 5, 8-9, 11-12, 14, Figures 1-14, Methods from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

PDF file - 839K</p