* Fermi National Accelerator Laboratory FERMIIAB Conf-95/146-E CDF and D0 W/Z + Jets Production at the Tevatron PP Collider

Abstract Both the DO and CDF experiments at Fermilab Tevatron collider at fi = 1.8TeV have accumuiated over 13pb -' of data during the 1992-1993 collider run. Each experiment collected more than 10,000 W + 1-t v and 1,000 2 -+ 1 + j candidates for each lepton species (e and /A). Using this large data sample of W and Z candidates, the two experiments are actively testing perturbative QCD predictions. Among the studies that are in progress, preliminary results of Z+jets characteristics, multiplicity distributions of associated jets, and a determination of the strong coupling constant using the ratio of the W+ljet to W + Ojet cross sections are presented

Optically Levitated Nanodumbbell Torsion Balance and GHz Nanomechanical Rotor

Levitated optomechanics has great potentials in precision measurements, thermodynamics, macroscopic quantum mechanics and quantum sensing. Here we synthesize and optically levitate silica nanodumbbells in high vacuum. With a linearly polarized laser, we observe the torsional vibration of an optically levitated nanodumbbell in vacuum. The linearly-polarized optical tweezer provides a restoring torque to confine the orientation of the nanodumbbell, in analog to the torsion wire which provides restoring torque for suspended lead spheres in the Cavendish torsion balance. Our calculation shows its torque detection sensitivity can exceed that of the current state-of-the-art torsion balance by several orders. The levitated nanodumbbell torsion balance provides rare opportunities to observe the Casimir torque and probe the quantum nature of gravity as proposed recently. With a circularly-polarized laser, we drive a 170-nm-diameter nanodumbbell to rotate beyond 1~GHz, which is the fastest nanomechanical rotor realized to date. Our calculations show that smaller silica nanodumbbells can sustain rotation frequency beyond 10 GHz. Such ultrafast rotation may be used to study material properties and probe vacuum friction

Search for Boosted Dark Matter at ProtoDUNE

We propose the first experimental test of the inelastic boosted dark matter hypothesis, capitalizing on the new physics potential with the imminent data taking of the ProtoDUNE detectors. More specifically, we explore various experimental signatures at the cosmic frontier, arising in boosted dark matter scenarios, i.e., relativistic, inelastic scattering of boosted dark matter often created by the annihilation of its heavier component which usually comprises of the dominant relic abundance. Although features are unique enough to isolate signal events from potential backgrounds, vetoing a vast amount of cosmic background is rather challenging as the detectors are located on the ground. We argue, with a careful estimate, that such backgrounds nevertheless can be well under control by performing dedicated analyses after data acquisition. We then discuss some phenomenological studies which can be achieved with ProtoDUNE, employing a dark photon scenario as our benchmark dark-sector model.Comment: Supplemental material include

The Beam-Dump Ceiling and Its Experimental Implication: The Case of a Portable Experiment

We generalize the nature of the so-called beam-dump "ceiling" beyond which the improvement on the sensitivity reach in the search for fast-decaying mediators dramatically slows down, and point out its experimental implications that motivate tabletop-size beam-dump experiments for the search. Light (bosonic) mediators are well-motivated new-physics particles as they can appear in dark-sector portal scenarios and models to explain various laboratory-based anomalies. Due to their low mass and feebly interacting nature, beam-dump-type experiments, utilizing high-intensity particle beams can play a crucial role in probing the parameter space of visibly decaying such mediators, in particular, the ``prompt-decay'' region where the mediators feature relatively large coupling and mass. We present a general and semi-analytic proof that the ceiling effectively arises in the prompt-decay region of an experiment and show its insensitivity to data statistics, background estimates, and systematic uncertainties, considering a concrete example, the search for axion-like particles interacting with ordinary photons at three benchmark beam facilities, PIP-II at FNAL and SPS and LHC-dump at CERN. We then identify optimal criteria to perform a cost-effective and short-term experiment to reach the ceiling, demonstrating that very short-baseline compact experiments enable access to the parameter space unreachable thus far.Comment: 6 pages, 2 figures, 1 tabl

Solvent: A Framework for Protein Folding

Consistency and reliability are crucial for conducting AI research. Many famous research fields, such as object detection, have been compared and validated with solid benchmark frameworks. After AlphaFold2, the protein folding task has entered a new phase, and many methods are proposed based on the component of AlphaFold2. The importance of a unified research framework in protein folding contains implementations and benchmarks to consistently and fairly compare various approaches. To achieve this, we present Solvent, an protein folding framework that supports significant components of state-of-the-art models in the manner of off-the-shelf interface Solvent contains different models implemented in a unified codebase and supports training and evaluation for defined models on the same dataset. We benchmark well-known algorithms and their components and provide experiments that give helpful insights into the protein structure modeling field. We hope that Solvent will increase the reliability and consistency of proposed models and gives efficiency in both speed and costs, resulting in acceleration on protein folding modeling research. The code is available at https://github.com/kakaobrain/solvent, and the project will continue to be developed.Comment: preprint, 8page

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair.

Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation. The cellular function of active DNA demethylation in neurons, however, remains largely unknown. Tet family proteins oxidize 5-methylcytosine to initiate active DNA demethylation through the base-excision repair (BER) pathway. We found that synaptic activity bi-directionally regulates neuronal Tet3 expression. Functionally, knockdown of Tet or inhibition of BER in hippocampal neurons elevated excitatory glutamatergic synaptic transmission, whereas overexpressing Tet3 or Tet1 catalytic domain decreased it. Furthermore, dysregulation of Tet3 signaling prevented homeostatic synaptic plasticity. Mechanistically, Tet3 dictated neuronal surface GluR1 levels. RNA-seq analyses further revealed a pivotal role of Tet3 in regulating gene expression in response to global synaptic activity changes. Thus, Tet3 serves as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-plasticity of neurons via active DNA demethylation