The cumulative incidence curves of ischemic stroke estimated by cause-specific Cox proportional hazard regression model.

The cumulative incidence curves of ischemic stroke estimated by cause-specific Cox proportional hazard regression model.</p

Comparison of non-blepharitis and blepharitis cohorts.

Comparison of non-blepharitis and blepharitis cohorts.</p

Risk stratification for ischemic stroke in non-blepharitis and blepharitis cohorts.

Risk stratification for ischemic stroke in non-blepharitis and blepharitis cohorts.</p

The risks of ischemic stroke in the blepharitis cohort relative to the non-blepharitis cohort in terms of different follow-up time.

The risks of ischemic stroke in the blepharitis cohort relative to the non-blepharitis cohort in terms of different follow-up time.</p

Risk factors of ischemic stroke.

IntroductionTo investigate the association of blepharitis and ischemic stroke.MethodsThis nationwide retrospective cohort study used population-based data in Taiwan. Individuals aged 20 and above with diagnosis of blepharitis was included based on electrical medical records. After exclusion of ineligible cases, 424,161 patients were identified between 2008 and 2018. The blepharitis and non-blepharitis cohorts were matched based on sex, age, and comorbidities. Multivariable-adjusted Cox proportional hazards model was adopted to calculate the hazard ratio and 95% confidence interval (CI) between blepharitis and non-blepharitis cohorts. The incidence of ischemic stroke was estimated by Kaplan–Meier analysis.Results424,161 pairs of blepharitis cohort and non-blepharitis cohort were 1:1 propensity score matched for statistical analysis. Patients with blepharitis had significantly increased risk of ischemic stroke compared with the individuals without blepharitis (adjusted hazard ratio 1.32, 95% CI 1.29–1.34, P P for interaction P P ConclusionsPatients with blepharitis had an elevated risk of developing ischemic stroke. Early treatment and active surveillance are suggested for patients with chronic blepharitis. Further research is required to determine the casual relationship between blepharitis and ischemic stroke, as well as the underlying mechanism.</div

Study flow chart.

IntroductionTo investigate the association of blepharitis and ischemic stroke.MethodsThis nationwide retrospective cohort study used population-based data in Taiwan. Individuals aged 20 and above with diagnosis of blepharitis was included based on electrical medical records. After exclusion of ineligible cases, 424,161 patients were identified between 2008 and 2018. The blepharitis and non-blepharitis cohorts were matched based on sex, age, and comorbidities. Multivariable-adjusted Cox proportional hazards model was adopted to calculate the hazard ratio and 95% confidence interval (CI) between blepharitis and non-blepharitis cohorts. The incidence of ischemic stroke was estimated by Kaplan–Meier analysis.Results424,161 pairs of blepharitis cohort and non-blepharitis cohort were 1:1 propensity score matched for statistical analysis. Patients with blepharitis had significantly increased risk of ischemic stroke compared with the individuals without blepharitis (adjusted hazard ratio 1.32, 95% CI 1.29–1.34, P P for interaction P P ConclusionsPatients with blepharitis had an elevated risk of developing ischemic stroke. Early treatment and active surveillance are suggested for patients with chronic blepharitis. Further research is required to determine the casual relationship between blepharitis and ischemic stroke, as well as the underlying mechanism.</div