161 research outputs found
Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer
Most of Solute carrier family-2 (SLC2) members play a key role of facilitative transporters, and glucose transporter (GLUT) proteins encoded by SLC2s can transport hexoses or polyols. However, the function and mechanism of SLC2s remain unclear in human cancers. Here, we explored the dysregulated expression, prognostic values, epigenetic, genetic alterations, and biomolecular network of SLC2s in human cancers. According to the data from public-omicsrepository, SLC2A4 (GLUT4) was found to be significantly downregulated in most cancers, and higher messenger RNA (mRNA) expression of SLC2A4 significantly associated with better prognosis of breast cancer (BRCA) patients. Moreover, DNA hypermethylation in the promoter of SLC2A4 may affect the regulation of its mRNA expression, and SLC2A4 was strongly correlated with pathways, including the translocation of SLC2A4 to the plasma membrane and PID INSULIN PATHWAY. In conclusion, these results provide insight into SLC2s in human cancers and suggest that SLC2A4 could be an unfavorable prognostic biomarker for the survival of BRCA patients.</p
Design, Synthesis, and Acaricidal/Insecticidal Activities of Oxazoline Derivatives Containing a Sulfur Ether Moiety
On
the basis of etoxazole, a series of novel 2-(2,6-difluorophenyl)-4-(4-substituted
phenyl)-1,3-oxazolines containing a sulfur ether moiety were designed
and synthesized via the key intermediate <i>N</i>-(1-(4-(bromomethyl)Âphenyl)-2-chloroethyl)-2,6-difluorobenzamide.
The bioassay results showed that most of these designed target compounds
exhibited excellent acaricidal activity against both the eggs and
larvae of <i>Tetranychus cinnabarinus</i>, especially the
eggs. Among compounds with high activity against the eggs of mites,
the LC<sub>50</sub> values of <b>2</b>, <b>11</b>, <b>17</b>, and <b>19</b> were 0.0003, 0.0002, 0.0005, and 0.0008
mg L<sup>–1</sup>, respectively, much lower than that of etoxazole
(0.0089 mg L<sup>–1</sup>). Compound <b>2</b> was chosen
to evaluate the acaricidal activity in the field, and the results
displayed that at a concentration of 22 mg kg<sup>–1</sup>, <b>2</b> had a much better control effect than etoxazole against
both <i>T. cinnabarinus</i> and <i>P. latus</i> on eggplant. Some compounds also showed good insecticidal activities
against oriental armyworm and mosquito. On the basis of our research,
the newly found structure–activity relationship may guide the
development of new acaricides/pesticides that are required in the
agriculture market
Correlation relationships between C, N and P among plant communities in the YRD.
Correlation relationships between C, N and P among plant communities in the YRD.</p
The distribution of SOC concentration at varying soil depths in the 0–60 cm layer.
Bars indicate a significant difference (n = 4, p<0.05) at the same soil depths between different plant communities, as determined by ANOVA; AG: alfalfa grassland, CT: Chinese tamarisk, LF: locust forest and CF: cotton field.</p
The distribution of soil AP concentration at varying soil depths in the 0–60 cm layer.
Bars indicate a significant difference (n = 4, p<0.05) at the same soil depth between different plant communities, as determined by ANOVA; AG: alfalfa grassland, CT: Chinese tamarisk, LF: locust forest and CF: cotton field.</p
The ratio of soil carbon to nitrogen (C:N) among plant communities.
Bars indicate a significant difference (n = 4, p<0.05) between plant communities at the same soil depth, as determined by ANOVA; AG: alfalfa grassland, CT: Chinese tamarisk, LF: locust forest and CF: cotton field.</p
Seasonal dynamics of C:N ratio among plant communities and average C:N ratio.
Bars indicate a significant difference (n = 4, p<0.05) between different seasons, and average concentration is between plant communities, as determined by ANOVA; AG: alfalfa grassland, CT: Chinese tamarisk, LF: locust forest and CF: cotton field.</p
The study location and plant communities of the northeast estuarine area in the YRD, China.
The study location and plant communities of the northeast estuarine area in the YRD, China.</p
The distribution of soil TN concentration at varying soil depths in the 0–60 cm layer.
Bars indicate a significant difference (n = 4, p<0.05) at the same soil depth between different plant communities, as determined by ANOVA; AG: alfalfa grassland, CT: Chinese tamarisk, LF: locust forest and CF: cotton field.</p
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