67 research outputs found

    Design, Synthesis, and Acaricidal/Insecticidal Activities of Oxazoline Derivatives Containing a Sulfur Ether Moiety

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    On the basis of etoxazole, a series of novel 2-(2,6-difluorophenyl)-4-(4-substituted phenyl)-1,3-oxazolines containing a sulfur ether moiety were designed and synthesized via the key intermediate <i>N</i>-(1-(4-(bromomethyl)­phenyl)-2-chloroethyl)-2,6-difluorobenzamide. The bioassay results showed that most of these designed target compounds exhibited excellent acaricidal activity against both the eggs and larvae of <i>Tetranychus cinnabarinus</i>, especially the eggs. Among compounds with high activity against the eggs of mites, the LC<sub>50</sub> values of <b>2</b>, <b>11</b>, <b>17</b>, and <b>19</b> were 0.0003, 0.0002, 0.0005, and 0.0008 mg L<sup>–1</sup>, respectively, much lower than that of etoxazole (0.0089 mg L<sup>–1</sup>). Compound <b>2</b> was chosen to evaluate the acaricidal activity in the field, and the results displayed that at a concentration of 22 mg kg<sup>–1</sup>, <b>2</b> had a much better control effect than etoxazole against both <i>T. cinnabarinus</i> and <i>P. latus</i> on eggplant. Some compounds also showed good insecticidal activities against oriental armyworm and mosquito. On the basis of our research, the newly found structure–activity relationship may guide the development of new acaricides/pesticides that are required in the agriculture market

    Design, Synthesis, Acaricidal/Insecticidal Activity, and Structure–Activity Relationship Studies of Novel Oxazolines Containing Sulfone/Sulfoxide Groups Based on the Sulfonylurea Receptor Protein-Binding Site

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    Enormous compounds containing sulfone/sulfoxide groups have been used in a variety of fields, especially in drug and pesticide design. To search for novel environmentally benign and ecologically safe pesticides with unique modes of action, a series of 2,4-diphenyl-1,3-oxazolines containing sulfone/sulfoxide groups as chitin synthesis inhibitors (CSIs) were designed and synthesized on the basis of the sulfonylurea receptor protein-binding site for CSIs. Their structures were characterized by <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance and high-resolution mass spectrometry. The acaricidal and insecticidal activities of the new compounds were evaluated. It was found that most of the target compounds displayed wonderful acaricidal activities against spider mite (Tetranychus cinnabarinus) larvae and eggs. Especially compounds <b>I-4</b>, <b>II-3</b>, and <b>II-4</b> displayed higher activities than commercial etoxazole at a concentration of 2.5 mg L<sup>–1</sup>. Some target compounds exhibited insecticidal activities against lepidopteran pests. The present work demonstrated that these compounds containing sulfone/sulfoxide groups could be considered as potential candidates for the development of novel acaricides in the future

    Data_Sheet_1_Genetic diversity and phylogenetic characteristics of viruses in lily plants in Beijing.docx

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    Lily (Lilium) is an important bulbous perennial herb that is frequently infected by one or more viruses. To investigate the diversity of lily viruses, lilies with virus-like symptoms in Beijing were collected to perform small RNA deep sequencing. Then, the 12 complete and six nearly full-length viral genomes, including six known viruses and two novel viruses were determined. Based on sequence and phylogenetic analyses, two novel viruses were considered to be members of the genera Alphaendornavirus (Endornaviridae) and Polerovirus (Solemoviridae). These two novel viruses were provisionally named lily-associated alphaendornavirus 1 (LaEV-1) and lily-associated polerovirus 1 (LaPV-1). Based on sequence, phylogenetic and recombination analyses, strawberry latent ringspot virus (SLRSV) in the genus Stralarivirus (Secoviridae) was identified for the first time in China, and shown to exhibit the highest nucleotide (nt) diversity among the available full-length SLRSV genome sequences, with the highest identities of 79.5% for RNA1 and 80.9% for RNA2. Interestingly, the protease cofactor region in RNA1 was 752 aa in length, whereas those of the other 27 characterized isolates ranged from 700–719 aa in length. The genome sequences of lily virus A (Potyvirus), lily virus X (Potexvirus), and plantago asiatica mosaic virus (Potexvirus) exhibited varying degrees of sequence diversity at the nucleotide level compared with their corresponding characterized isolates. In addition, plantago asiatica mosaic virus (PlAMV) tended to cluster on a host species-basis. One identified lily mottle virus (Potyvirus) isolate was detected as a recombinant, and which clustered in a different group with four other isolates. Seven identified lily symptomless virus (Carlavirus) isolates, including one recombinant, were clustered into three clades. Our results revealed the genetic diversity of lily-infecting viruses, and sequence insertion, host species and recombination are factors that likely contribute to this diversity. Collectively, our results provide useful information regarding the control of viral disease in lily.</p

    Additional file 1 of Genome-wide analysis of key gene families in RNA silencing and their responses to biotic and drought stresses in adzuki bean

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    Additional file 1: Figure S1. MiRNA targets identified by psRobot. Table S1. Promoter analysis of VaDCLs. Table S2. Promoter analysis of VaAGOs. Table S3. Promoter analysis of VaRDRs. Table S4. Primers used in the QRT-PCR analysis

    Imaging data of No. 17 patient who had bilateral RCC with lung metastasis.

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    <p>(A1) Before neoadjuvant therapy, maximum tumor diameter in right kidney was 7 cm, maximum tumor diameter in left kidney was 4 cm. (B1) Right lung metastasis diameter was 1.5 cm. (A2) After left partial nephrectomy and successive 90 days of neoadjuvant therapy, maximum tumor diameter in right kidney was reduced to 5.2cm. (B2) Right lung metastasis diameter was 1.0 cm. (A3) After 150 days of neoadjuvant therapy, maximum tumor diameter in right kidney was 4.6 cm. (B1) Right lung metastasis diameter was 0.5 cm. </p

    Imaging data of No. 13 patient who had right RCC with tumor thrombus.

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    <p>(A) Right RCC with IVC grade III tumor thrombus before neoadjuvant therapy. IVC was obliterated. (B) After 92 days of neoadjuvant therapy, IVC thrombus was down–graded to grade II, IVC was partially recanalized. (C) Resected right kidney and IVC tumor thrombus.</p

    Imaging data of No. 11 patient who had left RCC with renal hilar lymph node metastasis.

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    <p>(A) Left kidney tumor and renal hilar lymph node metastasis before neo-adjuvant therapy. (B) After 86 days of neoadjuvant therapy, left kidney tumor downsized and renal hilar lymph node decreased, tumor partially necrotized. (C) Section of resected left kidney, showing partial tumor necrosis and fibrosis.</p
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