Association between interleukin-6 and preterm birth: a meta-analysis

Interleukin (IL)-6 is a pro-inflammatory cytokine that plays an important role in preterm birth (PTB), Several meta-analyses investigated the association between IL-6 and PTB, but definitive conclusion has not yet been achieved. This updated meta-analysis aimed to ascertain the association between IL-6 and PTB by examining IL-6 levels in both normal birth and PTB groups. Prospective cohort studies were retrieved in PubMed, Embase, and the Cochrane library from their inception until 18 February 2020. The primary outcome was the association between IL-6 and PTB, and secondary outcomes were the association between IL-6 and spontaneous PTB. Nine studies involving 1904 patients were included. Overall, IL-6 from different sample types (maternal blood, amniotic fluid and cervicovaginal fluid) was associated with PTB (standard mean difference [SMD]: 0.86, 95% confidence interval [CI]: 0.32 to 1.39, p p p = 0.022), but not significant in maternal blood (SMD: −0.11, 95%CI: −0.57 to 0.34, p = 0.623). In addition, IL-6 was also associated with spontaneous PTB (SMD: 1.57, 95% CI: 0.18 to 2.95, p  Based on the available evidence, IL-6 in amniotic fluid and cervicovaginal fluid might be useful for predicting preterm birth. KEY MESSAGESBased on the available evidenceIL-6 in amniotic fluid and cervicovaginal fluid might be useful for predicting preterm birth Based on the available evidence IL-6 in amniotic fluid and cervicovaginal fluid might be useful for predicting preterm birth</p

Le Petit Marocain

31 août 19431943/08/31 (A31,N7918)-1943/08/31

Profile of microRNA in Giant Panda Blood: A Resource for Immune-Related and Novel microRNAs

<div><p>The giant panda (<i>Ailuropoda melanoleuca</i>) is one of the world’s most beloved endangered mammals. Although the draft genome of this species had been assembled, little was known about the composition of its microRNAs (miRNAs) or their functional profiles. Recent studies demonstrated that changes in the expression of miRNAs are associated with immunity. In this study, miRNAs were extracted from the blood of four healthy giant pandas and sequenced by Illumina next generation sequencing technology. As determined by miRNA screening, a total of 276 conserved miRNAs and 51 novel putative miRNAs candidates were detected. After differential expression analysis, we noticed that the expressions of 7 miRNAs were significantly up-regulated in young giant pandas compared with that of adults. Moreover, 2 miRNAs were up-regulated in female giant pandas and 1 in the male individuals. Target gene prediction suggested that the miRNAs of giant panda might be relevant to the expressions of 4,602 downstream genes. Subseuqently, the predicted target genes were conducted to KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis and we found that these genes were mainly involved in host immunity, including the Ras signaling pathway, the PI3K-Akt signaling pathway, and the MAPK signaling pathway. In conclusion, our results provide the first miRNA profiles of giant panda blood, and the predicted functional analyses may open an avenue for further study of giant panda immunity.</p></div

Category annotation for all samples.

<p>(A) Unique reads in F18. (B) Unique reads in M12. (C) Unique reads in F06. (D) Unique reads in M05.</p

Partial secondary structure of novel miRNAs.

<p>The entire sequence represents pre-miRNAs.</p

Frequency distribution of sequence lengths of sequencing results in all samples.

<p>(A) The lengths for F18. (B)The lengths for M12. (C) The lengths for F06. (D) The lengths for M05.</p

Summary the gender and age for all samples.

<p>Summary the gender and age for all samples.</p

Differentially expressed miRNAs in the male group and female individuals.

<p>Differentially expressed miRNAs in the male group and female individuals.</p

Summary of miRNAs sequencing.

<p>Summary of miRNAs sequencing.</p

Differentially expressed miRNAs in the adult group and young individuals.

<p>Differentially expressed miRNAs in the adult group and young individuals.</p