Data_Sheet_1_Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study.docx

IntroductionThis study aimed to assess the correlation between the blood urea nitrogen (BUN)-to-creatinine (BUN/Cr) ratio and adverse outcomes (AOs) at 3 months in patients with acute ischemic stroke (AIS) in the Korean population.MethodsThis cohort study encompassed 1906 cases of AIS at a South Korean hospital from January 2010 to December 2016. To determine the linear correlation between the BUN/Cr ratio and AOs in AIS, a binary logistic regression model (BLRM) was employed. Additionally, generalized additive models and techniques for smooth curve fitting were utilized to reveal the nonlinear dynamics between the BUN/Cr ratio and AOs in patients with AIS.ResultsThe prevalence of AOs was 28.65%, with a median BUN/Cr ratio of 18.96. Following adjustments for covariates, the BLRM disclosed that the association between the BUN/Cr ratio and the risk of AOs in patients with AIS did not attain statistical significance. Nevertheless, a nonlinear relationship surfaced, pinpointing an inflection point at 21.591. To the left of this inflection point, a 31.42% reduction in the risk of AOs was noted for every 1-unit surge in the Z score of the BUN/Cr ratio [odds ratio (OR) = 0.686, 95% confidence interval (CI): 0.519, 0.906, p = 0.008]. On the right side of the inflection point, the effect size (OR = 1.405, 95% CI: 1.018, 1.902, p = 0.039) was determined.ConclusionThe findings of this study underscore the intricate nature of the relationship between the BUN/Cr ratio and 3-month outcomes in patients with AIS, establishing a robust groundwork for future investigations.</p

Corrosion rate of Pure Mg and Mg-RE alloys.

<p>(<b>A</b>) Potentiodynamic polarization curves in HBS, and (<b>B</b>) Electrochemical corrosion data of Pure Mg and Mg alloys.</p

Mechanical strength of pure Mg and Mg-RE alloys at room temperature.

<p>Mechanical strength of pure Mg and Mg-RE alloys at room temperature.</p

Representative SEM images of platelet adhesion and activation on Mg materials.

<p>(<b>A</b>) pure Mg, and (<b>B–E</b>) R1–R4.</p

Representative optical images of HAECs morphology after treated with Mg material extracts for 7 days.

<p>Red arrow indicates the cell debris and dead cells.</p

The pH value of serum free ECM after incubation with cells and Mg materials for 24

<p>Stars indicate that the pH value is significantly different from that of pure Mg group (<i>P</i><0.05).</p

Representative fluorescent images of HAECs on Mg materials after 3

<p>(<b>A</b>) Pure Mg, (<b>B</b>) Tissue culture plate, and (<b>C–F</b>) R1–R4. Live cells are in green and dead cells are in red.</p

HAECs viability by MTT after treated with different Mg material extracts.

<p>(<b>A</b>) 2 days (<b>B</b>) 4 days, and (<b>C</b>) 7 days. Stars indicate that the cell viability is significantly different from that of pure Mg group (<i>P</i><0.05).</p

Representative fluorescent images of HAECs on Mg materials after 24

<p>(<b>A</b>) Pure Mg, (<b>B</b>) Tissue culture plate, and (<b>C–F</b>) R1–R4. Live cells are in green and dead cells are in red.</p

Hemolysis rate of diluted human whole blood after incubated with Mg materials for 1

<p>Hemolysis rate of diluted human whole blood after incubated with Mg materials for 1</p