Decelerating Airy pulse propagation in highly non-instantaneous cubic media

The propagation of decelerating Airy pulses in non-instantaneous cubic medium is investigated both theoretically and numerically. In a Debye model, at variance with the case of accelerating Airy and Gaussian pulses, a decelerating Airy pulse evolves into a single soliton for weak and general non- instantaneous response. Airy pulses can hence be used to control soliton generation by temporal shaping. The effect is critically dependent on the response time, and could be used as a way to measure the Debye type response function. For highly non- instantaneous response, we theoretically find a decelerating Airy pulse is still transformed into Airy wave packet with deceleration. The theoretical predictions are confirmed by numerical simulations

Research progress on the antitumor effects of harmine

Harmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects. Recent mechanistic studies have shown that harmine can inhibit cancer cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle regulation, angiogenesis, and the induction of tumor cell apoptosis. Furthermore, harmine reduces drug resistance when used in combination with chemotherapeutic drugs. Despite its remarkable antitumor activity, the application of harmine is limited by its poor solubility and toxic side effects, particularly neurotoxicity. Novel harmine derivatives have demonstrated strong clinical application prospects, but further validation based on drug activity, acute toxicity, and other aspects is necessary. Here, we present a review of recent research on the action mechanism of harmine in cancer treatment and the development of its derivatives, providing new insights into its potential clinical applications and strategies for mitigating its toxicity while enhancing its efficacy

Dependency Grammar Based English Subject-Verb Agreement Evaluation

PACLIC 23 / City University of Hong Kong / 3-5 December 200