Silver Triflate and Palladium Acetate Co-catalyzed Reaction of <i>N</i>′-(2-Alkynylbenzylidene)hydrazide with <i>N</i>-Allyl Ynamide

A silver triflate and palladium acetate co-catalyzed reaction of N′-(2-alkynylbenzylidene)hydrazide with N-allyl ynamide is described, which generates 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-endo cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization

Silver Triflate and Palladium Acetate Co-catalyzed Reaction of <i>N</i>′-(2-Alkynylbenzylidene)hydrazide with <i>N</i>-Allyl Ynamide

A silver triflate and palladium acetate co-catalyzed reaction of <i>N</i>′-(2-alkynylbenzylidene)hydrazide with <i>N</i>-allyl ynamide is described, which generates 2-amino-<i>H</i>-pyrazolo[5,1-<i>a</i>]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-<i>endo</i> cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization

Silver Triflate and Palladium Acetate Co-catalyzed Reaction of <i>N</i>′-(2-Alkynylbenzylidene)hydrazide with <i>N</i>-Allyl Ynamide

A silver triflate and palladium acetate co-catalyzed reaction of <i>N</i>′-(2-alkynylbenzylidene)hydrazide with <i>N</i>-allyl ynamide is described, which generates 2-amino-<i>H</i>-pyrazolo[5,1-<i>a</i>]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-<i>endo</i> cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization

Silver Triflate and Palladium Acetate Co-catalyzed Reaction of <i>N</i>′-(2-Alkynylbenzylidene)hydrazide with <i>N</i>-Allyl Ynamide

A silver triflate and palladium acetate co-catalyzed reaction of <i>N</i>′-(2-alkynylbenzylidene)hydrazide with <i>N</i>-allyl ynamide is described, which generates 2-amino-<i>H</i>-pyrazolo[5,1-<i>a</i>]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-<i>endo</i> cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization

Efficient Assembly of 1-(1<i>H</i>-Imidazol-1-yl)-3-methylene-1<i>H</i>-indenes via Tandem Reaction of (2-(Alkynyl)benzylidene)malonates with Imidazoles

The tandem nucleophilic addition and 5-exo-cyclization of (2-(alkynyl)benzylidene)malonates with imidazole derivatives in the presence of t-BuOK is reported. This reaction proceeds smoothly under mild conditions with high selectivity to afford the corresponding 1-(1H-imidazol-1-yl)-3-methylene-1H-indene-2,2(3H)-dicarboxylates in good to excellent yields

Novel Silver Tetrafluoroborate Catalyzed Electrophilic Cascade Cyclization Reaction: A Facile Approach to the Synthesis of Halo-Substituted Benzo[<i>a</i>]fluorenols

A facile and novel silver tetrafluoroborate catalyzed electrophilic cascade cyclization reaction to generate halo-substituted benzo[a]fluorenols under mild conditions is disclosed. Good chemical selectivity and mild reaction conditions were involved in the transformation. The halide-containing benzo[a]fluorenols could be further elaborated via palladium-catalyzed cross-coupling reactions to introduce complexity

Synthesis of 2,4-Dicyanoalkylated Benzoxazines through the Radical-Mediated Cascade Cyclization of Isocyanides with AIBN under Metal- and Additive-Free Conditions

A general and novel method for the radical cascade cyclization of aryl isocyanides with AIBN has been described. This strategy provides straightforward access to various 2,4-dicyanoalkylated benzoxazines in moderate to good yields under metal- and additive-free conditions. The reaction can apply to a gram scale and tolerate diverse functional groups. 2,4-Dicyanoalkylated benzoxazine derivatives feature a large Stokes shift and intramolecular charge transfer properties

Multicatalytic One-Pot Reaction of 1-(2-Alkynylphenyl)ketoximes for Generation of Indole Derivatives

Multicatalytic one-pot Beckmann rearrangement/intramolecular cyclization/halogenation reaction of 1-(2-alkynylphenyl)ketoxime is reported, leading to the expected indole derivatives in good yield

Novel Silver Tetrafluoroborate Catalyzed Electrophilic Cascade Cyclization Reaction: A Facile Approach to the Synthesis of Halo-Substituted Benzo[<i>a</i>]fluorenols

A facile and novel silver tetrafluoroborate catalyzed electrophilic cascade cyclization reaction to generate halo-substituted benzo[<i>a</i>]fluorenols under mild conditions is disclosed. Good chemical selectivity and mild reaction conditions were involved in the transformation. The halide-containing benzo[<i>a</i>]fluorenols could be further elaborated via palladium-catalyzed cross-coupling reactions to introduce complexity