Supplementary document for Regulation of multiple exceptional points in plasmonic quadrumer - 6973981.pdf

Supplementary Materia

Multifrequency and multimode topological waveguides in Stampfli-triangle photonic crystal with large valley Chern numbers

Topological photonics and its topological edge state which can suppress scattering and immune defects set off a research boom. Recently, the quantum valley Hall effect (QVHE) with large valley Chern number and its multimode topological transmission have been realized, which greatly improve the mode density of the topological waveguide and its coupling efficiency with other photonic devices. The multifrequency QVHE and its topological transmission have been realized to increase the transmission capacity of topological waveguide, but multifrequency and multimode QVHE have not been realized simultaneously. In this Letter, the valley photonic crystal (VPC) is constructed with the Stampfli-triangle photonic crystal (STPC), and its degeneracies in the low-frequency and high-frequency bands are broken simultaneously to realize the multifrequency and multimode QVHE. The multifrequency and multimode topological transmission is realized through the U-shaped waveguide constructed with two VPCs with opposite valley Chern numbers. According to the bulk-edge correspondence principle, the Chern number is equal to the number of topological edge states or topological waveguide modes. Therefore, we can determine the valley Chern number of the VPC by the number of topological edge states or topological waveguide modes, further determine the realization of large valley Chern number. These results provide new ideas for high-efficiency and high-capacity optical transmission and communication devices and their integration, and broaden the application range of topological edge states

Non-volatile heterogeneous III-V/Si photonics via optical charge-trap memory

We demonstrate, for the first time, non-volatile charge-trap flash memory (CTM) co-located with heterogeneous III-V/Si photonics. The wafer-bonded III-V/Si CTM cell facilitates non-volatile optical functionality for a variety of devices such as Mach-Zehnder Interferometers (MZIs), asymmetric MZI lattice filters, and ring resonator filters. The MZI CTM exhibits full write/erase operation (100 cycles with 500 states) with wavelength shifts of $\Delta\lambda_{non-volatile} = 1.16 nm$ ($\Delta n_{eff,non-volatile} ~ 2.5 \times 10^{-4}$) and a dynamic power consumption $<$ 20 pW (limited by measurement). Multi-bit write operation (2 bits) is also demonstrated and verified over a time duration of 24 hours and most likely beyond. The cascaded 2nd order ring resonator CTM filter exhibited an improved ER of ~ 7.11 dB compared to the MZI and wavelength shifts of $\Delta\lambda_{non-volatile} = 0.041 nm$ ($\Delta n_{eff, non-volatile} = 1.5 \times 10^{-4}$) with similar pW-level dynamic power consumption as the MZI CTM. The ability to co-locate photonic computing elements and non-volatile memory provides an attractive path towards eliminating the von-Neumann bottleneck

Radiative Anti-Parity-Time Plasmonics_Datasets

This file contains the datasets presented in the paper titled "Radiative Anti-Parity-Time Plasmonics".</p

Energy-Efficient Photonic Memory Based on Electrically Programmable Embedded III-V/Si Memristors: Switches and Filters

We demonstrate non-volatile optical functionality by embedding multi-layer $HfO_2/Al_2O_3$ memristors with III-V/Si photonics. The wafer-bonded III-V/Si memristor facilitates non-volatile optical functionality for a variety of devices such as Mach-Zehnder Interferometers (MZIs), and (de-)interleaver filters. The MZI optical memristor exhibits non-volatile optical phase shifts $> \pi (\Delta n_{g} > 2.70 \times 10^{-3}$) with ~ 30 dB extinction ratio while consuming 0 electrical power consumption in a true "set-and-forget" operation. We demonstrate 6 non-volatile states with each state capable of 4 Gbps modulation. III-V/Si (de-)interleavers were also demonstrated to exhibit memristive non-volatile passband transformation with full set/reset states. Time duration tests were performed on all devices and indicated non-volatility up to 24 hours and most likely beyond. To the best of our knowledge, we have demonstrated for the first time, non-volatile III-V/Si optical memristors with the largest electric-field driven phase shifts and reconfigurable filters with the lowest power consumption

Additional file 1 of NMR-based metabonomics reveals the dynamic effect of electro-acupuncture on central nervous system in gastric mucosal lesions (GML) rats

Additional file 1. Additional figures and tables

Reinforced Immunogenic Endoplasmic Reticulum Stress and Oxidative Stress via an Orchestrated Nanophotoinducer to Boost Cancer Photoimmunotherapy

Cancer progression and treatment-associated cellular stress impairs therapeutic outcome by inducing resistance. Endoplasmic reticulum (ER) stress is responsible for core events. Aberrant activation of stress sensors and their downstream components to disrupt homeostasis have emerged as vital regulators of tumor progression as well as response to cancer therapy. Here, an orchestrated nanophotoinducer (ERsNP) results in specific tumor ER-homing, induces hyperthermia and mounting oxidative stress associated reactive oxygen species (ROS), and provokes intense and lethal ER stress upon near-infrared laser irradiation. The strengthened “dying” of ER stress and ROS subsequently induce apoptosis for both primary and abscopal B16F10 and GL261 tumors, and promote damage-associated molecular patterns to evoke stress-dependent immunogenic cell death effects and release “self-antigens”. Thus, there is a cascade to activate maturation of dendritic cells, reprogram myeloid-derived suppressor cells to manipulate immunosuppression, and recruit cytotoxic T lymphocytes and effective antitumor response. The long-term protection against tumor recurrence is realized through cascaded combinatorial preoperative and postoperative photoimmunotherapy including the chemokine (C–C motif) receptor 2 antagonist, ERsNP upon laser irradiation, and an immune checkpoint inhibitor. The results highlight great promise of the orchestrated nanophotoinducer to exert potent immunogenic cell stress and death by reinforcing ER stress and oxidative stress to boost cancer photoimmunotherapy