The First Enantioenriched Metalated Nitrile Possessing Macroscopic Configurational Stability

Magnesium−bromine exchange on enantiopure cyclopropyl bromonitrile 5 at −100 °C for 1 min followed by a D2O quench gives the deuterionitrile in 81% ee (retention); additional trapping experiments establish t1/2(rac) = 11.4 h at −100 °C. These experiments provide the first glimpse into the stereochemical aspects of Mg−Br exchange. The intermediate formed is the first metalated nitrile demonstrated to possess macroscopic configurational stability

Bone marrow mesenchymal stem cells-derived exosomes suppress miRNA-5189-3p to increase fibroblast-like synoviocyte apoptosis via the BATF2/JAK2/STAT3 signaling pathway

Ankylosing spondylitis (AS) is characterized by inflammation of the sacroiliac joint and the attachment point of the spine. Herein, we aimed to investigate the effect of bone marrow mesenchymal stem cells (BMSCs)-derived exosomes on apoptosis of fibroblast-like synoviocytes (FLSs) and explored its molecular mechanism. Exosomes were isolated from BMSCs and verified by transmission electron microscope and nanoparticle tracking analysis. FLSs were isolated and co-incubated with BMSC exosomes. Cell apoptosis was assessed using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling analysis and flow cytometry. The results showed that BMSC exosomes increased apoptosis of FLSs. MiR-5189-3p was downregulated, while basic leucine zipper transcription factor ATF-like 2 (BATF2) was upregulated in FLSs by treatment of BMSC exosomes. As a direct target of miR-5189-3p, BATF2 inactivates the JAK2/STAT3 pathway. MiR-5189-3p suppressed apoptosis of FLSs and BATF2 exerted an opposite effect. In conclusion, BMSCs-derived exosomes suppress miR-5189-3p to facilitate the apoptosis of FLSs via the BATF2/JAK2/STAT3 signaling pathway, which facilitates the understanding of the therapeutic effect of BMSCs on AS and the underlying molecular mechanism.</p

Table S2 from Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas

For all genes represented in TCGA RNA-seq datasets, the mRNA-level correlations with metastasis for each cancer type.</p

Direct Tryptophols Synthesis from 2‑Vinylanilines and Alkynes via CC Triple Bond Cleavage and Dioxygen Activation

An unexpected metal-free CC triple bond cleavage, dioxygen activation, and reassembly into tryptophol derivatives has been developed. This chemistry provides a novel, simple, and efficient approach to highly valuable tryptophol derivatives from simple substrates under mild conditions. The mechanistic studies may promote the discovery of new methodologies through C–C bond cleavage and dioxygen activation

Supplementary document for Nonvolatile multilevel adjustable optical switch based on plasmonic slot waveguide and GST segmented structure - 6939142.pdf

Geometry Parameter Optimizatio

Table S4 from Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas

Gene Ontology (GO) term associations for the top metastasis-associated genes for each cancer type.</p

Direct Tryptophols Synthesis from 2‑Vinylanilines and Alkynes via CC Triple Bond Cleavage and Dioxygen Activation

An unexpected metal-free CC triple bond cleavage, dioxygen activation, and reassembly into tryptophol derivatives has been developed. This chemistry provides a novel, simple, and efficient approach to highly valuable tryptophol derivatives from simple substrates under mild conditions. The mechanistic studies may promote the discovery of new methodologies through C–C bond cleavage and dioxygen activation

Table S1 from Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas

TCGA cancer cases and molecular profiles examined in this study.</p

Supplementary Information from Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas

Supplementary Figures and Description of Data Files</p

Table S6 from Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas

For each cancer type, top metastasis-associated DNA methylation CpG Island features, selected using Pearson's correlation (logit-transformed values) with Storey and Tibshirini estimate of False Discovery Rate (FDR) of <10%. Differential mRNA statistics (metastasis versus primary) corresponding to the associated genes are also included.</p