8 research outputs found
DBU-Based Protic Ionic Liquids for CO<sub>2</sub> Capture
The
applications of the novel anion-functionalized protic ionic
liquid (ILs), prepared from superbase 1,8-diazabicyclo[5.4.0]undec-7-ene
(DBU) with imidazole, in the CO<sub>2</sub> absorption have been investigated.
It has been detected that this ionic liquid can reversibly capture
about 1 mol of CO<sub>2</sub> per mole ionic liquid. In addition,
the influence of temperature, pressure, water, and substituent of
anions has been uncovered. The capture of CO<sub>2</sub> was significantly
affected by the substituents in imidazole-based anion, suggesting
that electric-charge distribution in imidazole ring system can play
an important role in determining the reaction of ILs with CO<sub>2</sub>
Influence of C2–H of Imidazolium-Based Ionic Liquids on the Interaction and Vapor–Liquid Equilibrium of Ethyl Acetate + Ethanol System: [Bmim]BF<sub>4</sub> vs [Bmmim]BF<sub>4</sub>
The
effect of C2–H of alkylimidazolium tetrafluoroborate
ionic liquids on the interaction and vapor–liquid equilibrium
(VLE) of the ethyl acetate + ethanol mixture was studied using spectroscopy
and the COSMO-RS method. Concentration-dependent <sup>1</sup>H NMR
chemical shifts of ethyl acetate + ethanol + [Bmim]BF<sub>4</sub> or
[Bmmim]BF<sub>4</sub> (<i>x</i><sub>IL</sub> = 0.1 and 0.3)
systems show that the interaction between [Bmim]BF<sub>4</sub> and
ethanol is much stronger than that between [Bmmim]BF<sub>4</sub> and
ethanol. Moreover, the experimental and predicted VLE demonstrate
that the improvement of relative volatility of ethyl acetate to ethanol
by [Bmim]BF<sub>4</sub> is better than that by [Bmmim]BF<sub>4</sub>. Also, σ-profile obtained from COSMO-RS method indicates that
the hydrogen bonding donator ability of [Bmim]<sup>+</sup> is greater
than that of [Bmmim]<sup>+</sup>. Therefore, it can be deduced that
the acidic C2–H plays an important role in the interaction
differentiation of the ionic liquids and their effect on the VLE of
the ethyl acetate + ethanol system, resulting from the interaction
of the acidic C2–H with the ethanol that is much stronger than
with the ethyl acetate
Regiodivergent Kinetic Resolution of Terminal and Internal <i>rac</i>-Aziridines with Malonates under Dinuclear Schiff Base Catalysis
Regiodivergent parallel kinetic resolution
of aziridines with malonates
was achieved under dinuclear Schiff base catalysis. The regiodivergent
reaction proceeded under catalyst-control irrespective of the substituents
on the aziridines, and 2.5–10 mol % of a Y(OTf)<sub>3</sub>/La(O<i>i</i>Pr)<sub>3</sub>/a dinucleating Schiff base
= 1:1:1 mixture gave versatile γ-amino acid derivatives in 96
→ >99.5% ee. Not only terminal but also internal racemic
aziridines
reacted smoothly under suitably combined Lewis acid/Brønsted
base catalysis
Data File 1: General study of asymmetrical crossed Czerny–Turner spectrometer
Spectrogram values of mercury and CCL4 Originally published in Applied Optics on 20 November 2015 (ao-54-33-9966
Data File 5: High sensitivity and resolution integrated optical system for portable Raman spectrometer
Underlying values of the CCL4 spectrogram tested by two shortpass dichroic filters. Originally published in Applied Optics on 10 September 2016 (ao-55-26-7195
Data File 9: High sensitivity and resolution integrated optical system for portable Raman spectrometer
Underlying values of the glass rod spectrogram tested by the independent probe and monochromator and the integrated optical system. Originally published in Applied Optics on 10 September 2016 (ao-55-26-7195
Calcitonin Inhibits Phenotypic Switching of Aortic Smooth Muscle Cells and Neointimal Hyperplasia through the AMP-Activated Protein Kinase/Mechanistic Target of Rapamycin Pathway
Calcitonin (CT) is a peptide hormone secreted by the
parafollicular
C cells of the thyroid gland, salmon calcitonin was originally extracted
from the hind cheek of salmon. Neointimal hyperplasia refers to the
excessive proliferation and migration of vascular smooth muscle cells
(VSMCs). In this study, a rat model of restenosis was employed to
explore the impact of calcitonin on neointima proliferation. Calcitonin
was administered via continuous injections for a duration of 14 days
postsurgery, and the expression of proteins associated with proliferation,
migration, and phenotypic switching was assessed using the vascular
smooth muscle cells. Additionally, metabolomic analyses were conducted
to shed light on the mechanisms that underlie the role of calcitonin
in the development of cardiovascular disease. In our study, we found
that calcitonin possesses the capability to dispute the proliferation,
migration, and phenotypic transformation of VSMCs induced by platelet-derived
growth factor-BB (PDGF-BB) and 15% fetal bovine serum in vitro. Calcitonin
has demonstrated a favorable impact on smooth muscle cells, both in
vitro and in vivo. More specifically, it has been observed to mitigate
phenotypic switching, proliferation, and migration of these cells.
Moreover, calcitonin has been identified as a protective factor against
phenotypic switching and the formation of neointima, operating through
the AMP-activated protein kinase/mechanistic target of rapamycin (mTOR)
pathway