Base-Promoted Intermolecular Cyclization of Substituted 3‑Aryl(Heteroaryl)-3-chloro­acryl­aldehydes and Tetrahydro­isoquinolines: An Approach to Access Pyrrolo­[2,1‑<i>a</i>]­isoquinolines

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl­(heteroaryl)-3-chloroacryl­aldehydes and tetra­hydro­isoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo­[2,1-<i>a</i>]­isoquinolines. A number of pyrrolo­[2,1-<i>a</i>]­isoquinolines were synthesized in moderate to high yields (up to 97%)

Base-Promoted Intermolecular Cyclization of Substituted 3‑Aryl(Heteroaryl)-3-chloro­acryl­aldehydes and Tetrahydro­isoquinolines: An Approach to Access Pyrrolo­[2,1‑<i>a</i>]­isoquinolines

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl­(heteroaryl)-3-chloroacryl­aldehydes and tetra­hydro­isoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo­[2,1-<i>a</i>]­isoquinolines. A number of pyrrolo­[2,1-<i>a</i>]­isoquinolines were synthesized in moderate to high yields (up to 97%)

Asymmetric Phase-Transfer Catalysts Bearing Multiple Hydrogen-Bonding Donors: Highly Efficient Catalysts for Enantio- and Diastereoselective Nitro-Mannich Reaction of Amidosulfones

Bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors have rarely been explored. The first quaternary ammonium type of these catalysts derived from cinchona alkaloids were readily prepared and found to be highly efficient catalysts for asymmetric nitro-Mannich reactions of amidosulfones. Compared with previous reports, very broad substrate generality was observed, and both enantiomers of the products were achieved in high enantio- and diastereoselectivity (90–99% ee, 13:1 to 99:1 dr)

Bifunctional Thiourea–Ammonium Salt Catalysts Derived from Cinchona Alkaloids: Cooperative Phase-Transfer Catalysts in the Enantioselective Aza-Henry Reaction of Ketimines

An efficient enantioselective aza-Henry reaction of aryl α-ketoester-derived ketimines has been realized by using bifunctional thiourea–ammonium salt phase-transfer catalysts, which were derived from quinine. A variety of aryl α-ketoester-derived <i>N-</i>Ts ketimines were investigated, and the corresponding products were obtained in high to excellent yields (up to 99%) with good to high enantioselectivities (up to >99% ee)

The “Pure Marriage” between 3D Printing and Well-Ordered Nanoarrays by Using PEALD Assisted Hydrothermal Surface Engineering

For the first time, homogeneous and well-ordered functional nanoarrays were grown densely on the complex structured three-dimensional (3D) printing frameworks through a general plasma enhanced atomic layer deposition (PEALD) assisted hydrothermal surface engineering process. The entire process was free from toxic additives or harmful residues and, therefore, can meet the critical requirements of high-purity products. As a practical example, 3D customized earplugs were precisely manufactured according to the model of ear canals at the 0.1 mm level. Meanwhile, well-ordered ZnO nanoarrays, formed on the surfaces of these 3D printed earplugs, could effectively prevent the growth of five main pathogens derived from the patients with otitis media and exhibited excellent wear resistance as well. On the basis of both animal experiments and volunteers’ investigations, the 3D customized earplugs showed sound insulation capabilities superior to those of traditional earplugs. Further animal experiments demonstrated the potential of as-modified implant scaffolds in practical clinical applications. This work, exemplified with earplugs and implant scaffolds, oriented the development direction of 3D printing in biomedical devices, which precisely integrated customized architecture and tailored surface performance

The “Pure Marriage” between 3D Printing and Well-Ordered Nanoarrays by Using PEALD Assisted Hydrothermal Surface Engineering

For the first time, homogeneous and well-ordered functional nanoarrays were grown densely on the complex structured three-dimensional (3D) printing frameworks through a general plasma enhanced atomic layer deposition (PEALD) assisted hydrothermal surface engineering process. The entire process was free from toxic additives or harmful residues and, therefore, can meet the critical requirements of high-purity products. As a practical example, 3D customized earplugs were precisely manufactured according to the model of ear canals at the 0.1 mm level. Meanwhile, well-ordered ZnO nanoarrays, formed on the surfaces of these 3D printed earplugs, could effectively prevent the growth of five main pathogens derived from the patients with otitis media and exhibited excellent wear resistance as well. On the basis of both animal experiments and volunteers’ investigations, the 3D customized earplugs showed sound insulation capabilities superior to those of traditional earplugs. Further animal experiments demonstrated the potential of as-modified implant scaffolds in practical clinical applications. This work, exemplified with earplugs and implant scaffolds, oriented the development direction of 3D printing in biomedical devices, which precisely integrated customized architecture and tailored surface performance