Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice-4

Proteins identified in Arabidopsis. The CCCH zinc fingers are shown by black boxes. Types of zinc fingers are indicated by A to W, which are cross-indexed in the table on the right side. Numbers of amino acids in the spacers are indicated on each spacer region for several-fingered proteins. The lengths of each protein are shown on the right of the schematic structures. Numbers of different types of CCCH zinc finger proteins are presented in the brackets.<p><b>Copyright information:</b></p><p>Taken from "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice"</p><p>http://www.biomedcentral.com/1471-2164/9/44</p><p>BMC Genomics 2008;9():44-44.</p><p>Published online 27 Jan 2008</p><p>PMCID:PMC2267713.</p><p></p

Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice-0

residues, respectively. The three cysteine and one histidine residues putatively responsible for the zinc-finger structure are indicated.<p><b>Copyright information:</b></p><p>Taken from "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice"</p><p>http://www.biomedcentral.com/1471-2164/9/44</p><p>BMC Genomics 2008;9():44-44.</p><p>Published online 27 Jan 2008</p><p>PMCID:PMC2267713.</p><p></p

Additional file 1 of Epidemiology and clinical severity of the serotypes of human parainfluenza virus in children with acute respiratory infection

Supplementary Material

Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice-3

Een boxes indicate the duplicated segmental regions resulting from the most recent polyploidy. Only the duplicated regions containing CCCH genes are shown. Blue lines connect corresponding sister gene pairs in duplicated blocks. AtC3H1 and AtC3H51, AtC3H8 and AtC3H60, AtC3H12 and AtC3H28, AtC3H14 and AtC3H15, AtC3H30 and AtC3H56, AtC3H46 and AtC3H55, AtC3H59 and AtC3H62 are potential duplicated gene pairs which are marked with the same color rectangle, as described in the text.<p><b>Copyright information:</b></p><p>Taken from "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice"</p><p>http://www.biomedcentral.com/1471-2164/9/44</p><p>BMC Genomics 2008;9():44-44.</p><p>Published online 27 Jan 2008</p><p>PMCID:PMC2267713.</p><p></p

Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice-2

Ng tree: The unrooted tree, constructed using ClustalX (1.83), summarizes the evolutionary relationship among the 68 members of CCCH families. The neighbor-joining tree was constructed using aligned full-length amino acid sequences. The proteins are named according to their gene name (see Table 2) with the CCCH zinc finger number of each protein. The tree shows the 11 major phylogenetic subfamilies (left column, numbered I to XI and marked with different alternating tones of a gray background to make subfamily identification easier) with high predictive value. The numbers beside the branches represent bootstrap values (≥500) based on 1000 replications that were used to class the major 11 subfamilies. Gene structure: The gene structure is presented by black exon(s) and spaces between the black boxes correspond to introns. The sizes of exons and introns can be estimated using the horizontal lines. Protein structure: Each black box represents the motif in the protein, as indicated in the table on the left side. The conserved motifs outside CCCH motif are highlighted with an arranged number, and the same number referred to the same motif. The length of the motif can be estimated using the scale at top. aa, amino acids.<p><b>Copyright information:</b></p><p>Taken from "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice"</p><p>http://www.biomedcentral.com/1471-2164/9/44</p><p>BMC Genomics 2008;9():44-44.</p><p>Published online 27 Jan 2008</p><p>PMCID:PMC2267713.</p><p></p

Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice-1

Al MySQL database. The whole program is available in additional file (see Additional file and ).<p><b>Copyright information:</b></p><p>Taken from "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice"</p><p>http://www.biomedcentral.com/1471-2164/9/44</p><p>BMC Genomics 2008;9():44-44.</p><p>Published online 27 Jan 2008</p><p>PMCID:PMC2267713.</p><p></p

DataSheet1_Network Pharmacology and Data Mining Approach Reveal the Medication Rule of Traditional Chinese Medicine in the Treatment of Premenstrual Syndrome/Premenstrual Dysphoric Disorder.ZIP

Premenstrual syndrome (PMS) is a common disorder that affects women of reproductive age. It is characterized by periodic mental and somatic symptoms such as irritability, depression, and breast pain during the luteal phase. Premenstrual dysphoric disorder (PMDD) is the most severe form of PMS. In recent years, the incidence of PMS/PMDD has been increasing year after year. However, due to the complex symptoms and ambiguous classification of PMS/PMDD, the limitations of present treatments, such as their poor efficacy rate, have become increasingly apparent. With its unique benefits such as syndrome differentiation and high cure rate, traditional Chinese medicine (TCM) has sparked new diagnosing and treating of PMS/PMDD. This study uses data mining methods, and statistical analysis revealed that Xiaoyao San and Chaihu Shugan San were the commonly used TCM to treat PMS/PMDD. A detailed investigation of regularly used single herbs revealed that most TCM is used as cold herbs that penetrate the liver meridian, with predominant bitter, sweet, and pungent flavors. The network pharmacology method analyzes the interactions between diseases, targets, and herbs. Meanwhile, the deep action targets and molecular mechanisms of 10 commonly used herbs for the treatment of PMS/PMDD are studied, revealing that it involves several ingredients, many targets, and different pathways. This interaction provides insight into the mechanism of action of TCM in the synergistic treatment of PMS/PMDD. It is now clear that we can begin treating PMS/PMDD with TCM using the target and mechanism revealed by the abovementioned findings in the future. This serves as an essential reference for future research and clinical application of TCM in the treatment of PMS/PMDD.</p

Data_Sheet_1_Gene Expression in the Hippocampus in a Rat Model of Premenstrual Dysphoric Disorder After Treatment With Baixiangdan Capsules.ZIP

Objective: To explore the targets, signal regulatory networks and mechanisms involved in Baixiangdan (BXD) capsule regulation of premenstrual dysphoric disorder (PMDD) at the gene transcription level, since the etiology and pathogenesis of PMDD are not well understood.Methods: The PMDD rat model was prepared using the resident-intruder paradigm. The rats were tested for aggressive behavior, and those with scores in the lowest 30% were used as controls, while rats with scores in the highest 30% were divided into a PMDD model group, BXD administration group and fluoxetine administration group, which were evaluated with open-field tests and aggressive behavior tests. We also analyzed gene expression profiles in the hippocampus for each group, and verified differential expression of genes by real-time PCR.Results: Before and after BXD or fluoxetine administration, scores in the open-field test exhibited no significant differences. The aggressive behavior of the PMDD model rats was improved to a degree after administration of both substances. Gene chip data indicated that 715 genes were differentially expressed in the control and BXD groups. Other group-to-group comparisons exhibited smaller numbers of differentially expressed genes. The effective targets of both drugs included the Htr2c, Cdh3, Serpinb1a, Ace, Trpv4, Cacna1a, Mapk13, Mapk8, Cyp2c13, and Htr1a genes. The results of real-time PCR tests were in accordance with the gene chip data. Based on the target genes and signaling pathway network analysis, we have elaborated the impact and likely mechanism of BXD in treating PMDD and premenstrual irritability.Conclusion: Our work contributes to the understanding of PMDD pathogenesis and the mechanisms of BXD treatment. We speculate that the differentially expressed genes could participate in neuroactive ligand-receptor interactions, mitogen-activated protein kinase, calcium, and gamma-aminobutyric acid signal transduction.</p

Merging Geometric Phase and Plasmon Retardation Phase in Continuously Shaped Metasurfaces for Arbitrary Orbital Angular Momentum Generation

Traditional technologies to generate and manipulate the orbital angular momentum (OAM) suffer from bulky size and do not lend themselves to nanophotonic systems. An ultrathin metasurface based on abrupt phase shift has recently been proposed as an alternative method. Nevertheless, gradient phase was generally approximated by multiple meta-atom/molecules with discrete levels of abrupt phase shift, which not only increases the design and fabrication complexity but also causes difficulties in obtaining simultaneous electrical and optical functionality. Furthermore, a discontinuous phase profile would introduce phase noise to the scattering fields and deteriorate the purity of the OAM beams. Here, we propose a wavefront engineering mechanism by virtue of the spin–orbit interaction in continuously shaped plasmonic metasurfaces, which offers a new approach to generate OAM modes of high purity. Equally important, a method producing arbitrary OAM topological charge, integral and fractional, is demonstrated by merging the plasmon retardation phase with the geometric phase in the proposed continuously shaped metasurfaces. The proposed approach is well supported by full-wave numerical simulations and experimental characterization of the fabricated structure in the visible regime

Generation of Polarization-Sensitive Modulated Optical Vortices with All-Dielectric Metasurfaces

Optical vortices (OVs) created from helical modes of light have extensive applications in optical manipulation, imaging, and optical communications. Moreover, modulated optical vortices (MOVs) with modified wavefronts could provide new opportunities for fractionating particles and actuating microelectromechanical systems. Traditional devices for generating MOVs include spatial light modulators, spiral phase plates, and so on. However, such bulky devices are difficult to be applied to high-level integrated optical systems. Besides, other MOV generators are typically static and polarization-insensitive. Here, we proposed an all-dielectric metasurface to generate polarization-sensitive MOVs. The intensity patterns of the OVs can be modulated by adding a tangential modulation factor in the phase profile. Independent manipulation of two orthogonal polarizations was adopted via tailoring the geometric parameters of silicon (Si) pillars. We experimentally demonstrated that the metasurface could generate a doughnut and an actinomorphic vortex beams for different polarization inputs. In addition, the intensity pattern of the MOVs can be dynamically tuned by adjusting the polarization angle. This work can benefit optical manipulation and can be further extended to visible and near-infrared bands