Characteristics of 10 case-control studies included in the meta-analysis.

<p>BMI  =  body mass index; FFQ  =  food frequency questionnaire.</p

Forest plot: fish consumption and ovarian cancer risk among case-control studies.

<p>Squares indicated study-specific risk estimates (size of square reflects the study-statistical weight, i.e. inverse of variance); horizontal lines indicate 95% confidence intervals; diamond indicates summary relative risk estimate with its corresponding 95% confidence interval.</p

Forest plot: fish consumption and ovarian cancer risk among cohort studies.

<p>Squares indicated study-specific risk estimates (size of square reflects the study-statistical weight, i.e. inverse of variance); horizontal lines indicate 95% confidence intervals; diamond indicates summary relative risk estimate with its corresponding 95% confidence interval.</p

Funnel plot for publication bias in the studies investigating risk for ovarian cancer associated with fish intake.

<p>Funnel plot for publication bias in the studies investigating risk for ovarian cancer associated with fish intake.</p

Summary risk estimates of the association between fish consumption and ovarian cancer risk among case-control studies.

<p>CI, confidence interval; N/A, not available; RR, relative risk.</p

Image 1_v1_Prediction for 2-year mortality of metastatic ovarian cancer patients based on surveillance, epidemiology, and end results database.tiff

AimTo establish prediction models for 2-year overall survival of ovarian cancer patients with metastasis.MethodsIn total, 4,929 participants from Surveillance, Epidemiology, and End Results (SEER) database were randomly divided into the training set (n = 3,451) and the testing set (n = 1,478). Univariate and multivariable regression were conducted in the training set to identify predictors for 2-year overall survival of metastatic ovarian cancer patients. The C-index was calculated for assessing the performance of the models. The nomogram for the model was plotted. The prediction value of the model was validated in the testing set. Subgroup analysis were performed concerning surgery and chemotherapy status of patients and the metastatic site of ovarian cancer in the testing set. The calibration curves were plotted and the decision curve analysis (DCA) were conducted.ResultsAt the end of follow-up, 2,587 patients were survived and 2,342 patients were dead within 2 years. The 2-year survival rate was 52.5%. The prediction models were constructed based on predictors including age, radiation, surgery and chemotherapy, CA125, and bone, liver, and lung metastasis. The prediction model for 2-year overall survival of ovarian cancer patients with metastasis showed good predictive ability with the C-index of the model of 0.719 (95% CI: 0.706–0.731) in the training set and 0.718 (95% CI: 0.698–0.737) in the testing set. In terms of patients with bone metastasis, the C-index was 0.740 (95% CI: 0.652–0.828) for predicting the 2-year overall survival of ovarian cancer patients. The C-index was 0.836 (95% CI: 0.694–0.979) in patients with brain metastasis, 0.755 (95% CI: 0.721–0.788) in patients with liver metastasis and 0.725 (95% CI: 0.686–0.764) in those with lung metastasis for predicting the 2-year overall survival of ovarian cancer patients.ConclusionThe models showed good predictive performance for 2-year overall survival of metastatic ovarian cancer patients.</p

Triol-Ligand Modification and Structural Transformation of Anderson–Evans Oxomolybdates via Modulating Oxidation State of Co-Heteroatom

Various covalent decorations and structural transformations of a series of R–C­(CH₂OH)₃ triol ligands on Co^II/Co^III-centered Anderson–Evans polyoxomolybdates were studied in aqueous and/or organic solution. Single-crystal X-ray structural analysis demonstrated that four manners, including (1) double-sided χ/χ-isomer and (2) double-sided δ/χ-isomer with Co^II central heteroatom, and (3) single-sided δ-isomer and (4) double-sided δ/δ-isomer with Co^III central heteroatom, appeared on the decoration of the mother polyanion [Co^II/III(OH)₆Mo₆O₁₈]^4–/3–. Through careful manipulation of the reaction conditions, a gradual oxidation process from Co^II to Co^III was disclosed to happen in air, and accompanying that process, the Co^II-centered double-sided δ/χ-isomer that formed in the initial stage transformed into a Co^III-centered double-sided δ/δ-isomer. When the electron-withdrawing group −NO₂ substituted triol ligand was used to replace CH₃C­(CH₂OH)₃, the oxidation process accelerated spontaneously. A further investigation showed that this oxidation process can be blocked by acid. While the triol ligands’ decoration on Anderson–Evans polyoxometalates (POMs) took place along with the oxidation of the central heteroatom, that codecoration of other components was also accomplished. In the presence of excess acetic acid, an unprecedented single-sided δ-isomer with an acetate ligand covalently attaching on the other side by replacing one μ₃-O atom was obtained in aqueous solution. The reaction of the mother cluster [(<i>n</i>-C₄H₉)₄N]₃[Co­(OH)₆Mo₆O₁₈] and triol ligands in methanol resulted in a codecoration of methanol with the double-sided δ/δ-isomer, which has never been reported in B-type Anderson–Evans POMs. The obtained results revealed that the oxidation state of the heteroatom has a significant impact on the triol ligand decoration styles, such as the χ/χ- or δ/χ-isomer for the divalent heteroatom and the δ- or δ/δ-isomer for the trivalent heteroatom

Regions of decreased grey matter volume at baseline in antipsychotic-naïve patients with schizophrenia compared to healthy controls. <i>P</i><0.001, uncorrected, threshold = 50.

<p>Regions of decreased grey matter volume at baseline in antipsychotic-naïve patients with schizophrenia compared to healthy controls. <i>P</i><0.001, uncorrected, threshold = 50.</p

Regions of increased grey matter volume from baseline to follow-up in patients with schizophrenia.

<p>Regions of increased grey matter volume from baseline to follow-up in patients with schizophrenia.</p

Additional file 2 of Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord

Additional file 2. MAO-B abundance is decreased in the spinal cord neurons of CFA mice after FMD and selegiline treatment. Double immunofluorescence staining for MAO-B (red) and NeuN (green) in a spinal cord section (n = 3, scale bars: 50 or 100 μm)