242 research outputs found

    Direct effect model.

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    Note: The numbers listed in the figure are standardized solutions; The level of the kindergarten is included as a control variable in the model, but is not shown in the figure for the sake of simplicity; ** p p < 0.001.</p

    Hypothetical model diagram.

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    This study examines the relationship between family socioeconomic status, parent-child activities, and young children’s digital development. Using the Family SES questionnaire, the parent-child activities questionnaire, and the 5 to 6 year old children’s number sense development scale as research instruments, 314 young children (M = 70.42, SD = 3.47). The results show that: (1) Family Socioeconomic Status can significantly positively predict the young children’s number sense development; (2) Parent-child activities play a partial mediating role in the relationship between family socioeconomic status and the young children’s number sense development. This study provides specific guidelines and recommendations for improving the young children’s number sense development.</div

    Mediating effect value and Bootstrap test results.

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    Mediating effect value and Bootstrap test results.</p

    Mediation model diagram.

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    Note: The numbers listed in the figure are standardized solutions; The level of the kindergarten and gender are included as control variable in the model, but is not shown in the figure for the sake of simplicity; "pci1-pci4" refers to the four items of parent-child activity; ** p p < 0.001.</p

    Descriptive statistics of each variable and its correlation analysis results.

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    Descriptive statistics of each variable and its correlation analysis results.</p

    Incorporating "care" into design education through games

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    “Universal Care” can be regarded as the ultimate goal for Universal Design. It implies that design takes care of not only the user, but also the environment, and all other people directly or indirectly influenced by the design. However, “care” as a concept is not necessarily recognised or incorporated in existing design education.In order to understand what “care” means for design education, the authors have developed two models: the “care” model addresses an Interior Design context, mapping the designer, the client/design, and the environment, to care-giving and care-receiving roles; the “relations” model shows the overlapping between Client, Design object, Design and Environment, for a product design context.Subsequently two case studies (“My home” and “VI Boccia grid”) were presented to illustrate how the models could inform Interior Design education and accessible product design innovation. The game “My home” enabled the Interior Design students to have a detailed conversation about the client’s needs and family relations, thus helping raise the designer’s awareness of care. The “VI Boccia grid” is a game designed for visually impaired people, and the whole design process highlighted issues critical for the success of accessible product development. Design educators, students, design researchers and practitioners can learn from the two models and the two case studies when applying “care” in their design process.<br

    MOESM4 of Optimization and in vitro antiproliferation of Curcuma wenyujin’s active extracts by ultrasonication and response surface methodology

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    Additional file 4: Figure S3. Bar graph showing individual desirability values (d i ) of various objective responses and the maximum combined desirability of 0.971 for the optimization of ultrasonic extraction conditions for extraction of curdione, furanodienone, curcumol and germacrone from Curcuma wenyujin

    Thioketal-Based Electrochemical Sensor Reveals Biphasic Effects of l‑DOPA on Neuroinflammation

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    Neuroinflammation is linked closely to neurodegenerative diseases, with reactive oxygen species (ROS) exacerbating neuronal damage. Traditional electrochemical sensors show promise in targeting cellular ROS to understand their role in neuropathogenesis and assess therapies. Nevertheless, these sensors face challenges in mitigating the ROS oxidation overpotential. We herein introduce an ROS oxidation-independent nucleic acid sensor for in situ ROS analysis and therapeutic assessment. The sensor comprises ionizable and thioketal (TK)-based lipids with methylene blue-tagged nucleic acids on a glass carbon electrode. ROS exposure triggers cleavage within the sensor’s thioketal moiety, detaching the nucleic acid from the electrode and yielding quantifiable results via square-wave voltammetry. Importantly, the sensor’s low potential window minimizes interference, ensuring precise ROS measurements with high selectivity. Using this sensor, we unveil levodopa’s dose-dependent biphasic effect on neuroinflammation: low doses alleviate oxidative stress, while high doses exacerbate it. The TK-based sensor offers a promising methodology for investigating neuroinflammation’s pathogenesis and screening potential treatments, advancing neurodegenerative disease research

    <i>Let-7b</i> repletion selectively chemosensitizes <i>KRAS</i> mutant tumor cells.

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    <p>NSCLC cells A549 (<i>KRAS</i> mutant) and NIH-H1975 (<i>KRAS</i> wild-type), PDAC cells Panc-1 (<i>KRAS</i> mutant) and BxPC-3 (<i>KRAS</i> wild-type) were transfected with <i>let-7b</i> mimic (50 nM) or the scramble control (SCR, 50 nM) for 6 hours. The cells were then treated with paclitaxel (PTX, 0.1–50 nM) or gemcitabine (GEM, 5–150 nM or 5–150 μM) for 48 hours. Cell viability was assessed by the crystal violet assay. Each experiment was carried out at least 3 times. Data represent the mean ±SEM.</p

    <i>Let-7b</i> selectively downregulates mutant KRAS expression.

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    <p>The endogenous levels of <i>let-7b</i> (A), KRAS mRNA (B) and KRAS protein (C) in NIH-H1975, A549, BxPC-3 and Panc-1 cells. The expression of <i>let-7b</i> (D), KRAS protein (E) and KRAS mRNA (F) in the cells transfected with <i>let-7b</i> mimic alone or in combination with PTX or GEM. Each experiment was carried out at least 3 times. Data represent the mean ±SEM. *, <i>p</i> < 0.05; **, <i>p</i> < 0.01.</p
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